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Braz J Infect Dis. 2011 Nov-Dec;15(6):533-9.

Perinatal morbidity and mortality associated with chlamydial infection: a meta-analysis study.

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1
Postgraduate Program in Health Sciences, Universidade Federal do Rio Grande do Norte.

Abstract

OBJECTIVE:

To evaluate the effect of Chlamydia trachomatis infection during pregnancy on perinatal morbidity and mortality.

METHODS:

Systematic review and meta-analysis in an electronic database and manual, combining high sensitivity specific descriptors seeking to answer the research objective. The articles considered to be of high methodological quality (score above 6 on the Newcastle-Ottawa Scale) were assessed by meta-analysis.

RESULTS:

Summary estimates of 12 studies were calculated by means of Mantel-Haenszel test with 95% confidence interval. It was observed that Chlamydia infection during pregnancy increased risk of preterm labor (relative risk (RR) = 1.35 [1.11, 1.63]), low birth weight (RR = 1.52 [1.24, 1.87]) and perinatal mortality (RR = 1.84 [1.15, 2.94]). No evidence of increased risk was associated with Chlamydia infection in regard to premature rupture of membranes (RR = 1.13 [0.95, 1.34]), abortion and postpartum endometritis (RR = 1.20 [0.65, 2.20] and 0.89 [0.49, 1.61] respectively).

CONCLUSION:

The diagnosis and treatment of Chlamydia cervicitis during pregnancy can reduce perinatal morbidity and mortality associated with this infection. However, clinical trials are needed to confirm these findings.

PMID:
22218511
[Indexed for MEDLINE]
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