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Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3.

Clark HL, Abbondante S, Minns MS, Greenberg EN, Sun Y, Pearlman E.

Front Immunol. 2018 May 29;9:1182. doi: 10.3389/fimmu.2018.01182. eCollection 2018.


Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis.

Clark HL, Minns MS, Sun Y, de Jesus T, Ghannoum MG, Pearlman E.

Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1589-1598. doi: 10.1167/iovs.17-22585.


Pseudomonas aeruginosa Effector ExoS Inhibits ROS Production in Human Neutrophils.

Vareechon C, Zmina SE, Karmakar M, Pearlman E, Rietsch A.

Cell Host Microbe. 2017 May 10;21(5):611-618.e5. doi: 10.1016/j.chom.2017.04.001.


JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity.

Taylor PR, Roy S, Meszaros EC, Sun Y, Howell SJ, Malemud CJ, Pearlman E.

J Leukoc Biol. 2016 Jul;100(1):213-22. doi: 10.1189/jlb.4A1015-483R. Epub 2016 Mar 31.


Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP.

Karmakar M, Katsnelson MA, Dubyak GR, Pearlman E.

Nat Commun. 2016 Feb 15;7:10555. doi: 10.1038/ncomms10555.


Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection.

Clark HL, Jhingran A, Sun Y, Vareechon C, de Jesus Carrion S, Skaar EP, Chazin WJ, Calera JA, Hohl TM, Pearlman E.

J Immunol. 2016 Jan 1;196(1):336-44. doi: 10.4049/jimmunol.1502037. Epub 2015 Nov 18.


Inhibition of Corneal Inflammation by the Resolvin E1.

Lee JE, Sun Y, Gjorstrup P, Pearlman E.

Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2728-36. doi: 10.1167/iovs.14-15982. Erratum in: Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5739.


Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux.

Karmakar M, Katsnelson M, Malak HA, Greene NG, Howell SJ, Hise AG, Camilli A, Kadioglu A, Dubyak GR, Pearlman E.

J Immunol. 2015 Feb 15;194(4):1763-75. doi: 10.4049/jimmunol.1401624. Epub 2015 Jan 21.


Interleukin 17 expression in peripheral blood neutrophils from fungal keratitis patients and healthy cohorts in southern India.

Karthikeyan RS, Vareechon C, Prajna NV, Dharmalingam K, Pearlman E, Lalitha P.

J Infect Dis. 2015 Jan 1;211(1):130-4. doi: 10.1093/infdis/jiu381. Epub 2014 Jul 7.


Animal models to investigate fungal biofilm formation.

Chandra J, Pearlman E, Ghannoum MA.

Methods Mol Biol. 2014;1147:141-57. doi: 10.1007/978-1-4939-0467-9_10.


The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence.

Muszkieta L, Carrion Sde J, Robinet P, Beau R, Elbim C, Pearlman E, Latgé JP.

Fungal Genet Biol. 2014 May;66:79-85. doi: 10.1016/j.fgb.2014.02.009. Epub 2014 Mar 12.


Aspergillus and Fusarium corneal infections are regulated by Th17 cells and IL-17-producing neutrophils.

Taylor PR, Leal SM Jr, Sun Y, Pearlman E.

J Immunol. 2014 Apr 1;192(7):3319-27. doi: 10.4049/jimmunol.1302235. Epub 2014 Mar 3.


Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.

Taylor PR, Roy S, Leal SM Jr, Sun Y, Howell SJ, Cobb BA, Li X, Pearlman E.

Nat Immunol. 2014 Feb;15(2):143-51. doi: 10.1038/ni.2797. Epub 2013 Dec 22. Erratum in: Nat Immunol. 2015 Feb;16(2):214.


Host response and bacterial virulence factor expression in Pseudomonas aeruginosa and Streptococcus pneumoniae corneal ulcers.

Karthikeyan RS, Priya JL, Leal SM Jr, Toska J, Rietsch A, Prajna V, Pearlman E, Lalitha P.

PLoS One. 2013 Jun 4;8(6):e64867. doi: 10.1371/journal.pone.0064867. Print 2013.


Host defense at the ocular surface.

Pearlman E, Sun Y, Roy S, Karmakar M, Hise AG, Szczotka-Flynn L, Ghannoum M, Chinnery HR, McMenamin PG, Rietsch A.

Int Rev Immunol. 2013 Feb;32(1):4-18. doi: 10.3109/08830185.2012.749400. Review.


Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection.

Zhou R, Zhang R, Sun Y, Platt S, Szczotka-Flynn L, Pearlman E.

Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.


Fungal antioxidant pathways promote survival against neutrophils during infection.

Leal SM Jr, Vareechon C, Cowden S, Cobb BA, Latgé JP, Momany M, Pearlman E.

J Clin Invest. 2012 Jul;122(7):2482-98. doi: 10.1172/JCI63239. Epub 2012 Jun 18.


Characterization of fusarium keratitis outbreak isolates: contribution of biofilms to antimicrobial resistance and pathogenesis.

Mukherjee PK, Chandra J, Yu C, Sun Y, Pearlman E, Ghannoum MA.

Invest Ophthalmol Vis Sci. 2012 Jul 3;53(8):4450-7. doi: 10.1167/iovs.12-9848.


The role of cytokines and pathogen recognition molecules in fungal keratitis - Insights from human disease and animal models.

Leal SM Jr, Pearlman E.

Cytokine. 2012 Apr;58(1):107-11. doi: 10.1016/j.cyto.2011.12.022. Epub 2012 Jan 26. Review.


ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival.

Sun Y, Karmakar M, Taylor PR, Rietsch A, Pearlman E.

J Immunol. 2012 Feb 15;188(4):1884-95. doi: 10.4049/jimmunol.1102148. Epub 2012 Jan 16.

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