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Mechanisms underlying the role of DISC1 in synaptic plasticity.

Tropea D, Hardingham N, Millar K, Fox K.

J Physiol. 2018 Jul;596(14):2747-2771. doi: 10.1113/JP274330.


The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to microRNA-484.

Bradshaw NJ, Ukkola-Vuoti L, Pankakoski M, Zheutlin AB, Ortega-Alonso A, Torniainen-Holm M, Sinha V, Therman S, Paunio T, Suvisaari J, Lönnqvist J, Cannon TD, Haukka J, Hennah W.

Open Biol. 2017 Nov;7(11). pii: 170153. doi: 10.1098/rsob.170153.


The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression.

Azevedo JA, Carter BS, Meng F, Turner DL, Dai M, Schatzberg AF, Barchas JD, Jones EG, Bunney WE, Myers RM, Akil H, Watson SJ, Thompson RC.

J Psychiatr Res. 2016 Nov;82:58-67. doi: 10.1016/j.jpsychires.2016.07.012. Epub 2016 Jul 18.


Copy Number Variations in DISC1 and DISC1-Interacting Partners in Major Mental Illness.

Johnstone M, Maclean A, Heyrman L, Lenaerts AS, Nordin A, Nilsson LG, De Rijk P, Goossens D, Adolfsson R, St Clair DM, Hall J, Lawrie SM, McIntosh AM, Del-Favero J, Blackwood DH, Pickard BS.

Mol Neuropsychiatry. 2015 Oct;1(3):175-190. Epub 2015 Oct 7.


Association of PDE4B Polymorphisms with Susceptibility to Schizophrenia: A Meta-Analysis of Case-Control Studies.

Feng Y, Cheng D, Zhang C, Li Y, Zhang Z, Wang J, Shi Y.

PLoS One. 2016 Jan 12;11(1):e0147092. doi: 10.1371/journal.pone.0147092. eCollection 2016.


New insights into PDE4B inhibitor selectivity: CoMFA analyses and molecular docking studies.

Guariento S, Bruno O, Fossa P, Cichero E.

Mol Divers. 2016 Feb;20(1):77-92. doi: 10.1007/s11030-015-9631-1. Epub 2015 Aug 20.


Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.

McGirr A, Lipina TV, Mun HS, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JG, Liu F, Baillie GS, Clapcote SJ, Roder JC.

Neuropsychopharmacology. 2016 Mar;41(4):1080-92. doi: 10.1038/npp.2015.240. Epub 2015 Aug 14.


Postnatal neurodevelopmental expression and glutamate-dependent regulation of the ZNF804A rodent homologue.

Chang EH, Kirtley A, Chandon TS, Borger P, Husain-Krautter S, Vingtdeux V, Malhotra AK.

Schizophr Res. 2015 Oct;168(1-2):402-410. doi: 10.1016/j.schres.2015.06.023. Epub 2015 Jul 8.


Association analysis of PDE4B polymorphisms with schizophrenia and smooth pursuit eye movement abnormality in a Korean population.

Bae JS, Park BL, Cheong HS, Kim JH, Kim JY, Namgoong S, Kim JO, Park CS, Kim BJ, Lee CS, Kim JW, Choi WH, Shin TM, Hwang J, Koh IS, Shin HD, Woo SI.

Gen Physiol Biophys. 2015 Jul;34(3):277-84. doi: 10.4149/gpb_2015004. Epub 2015 Apr 30.


Selective Phosphodiesterase 4B Inhibitors: A Review.

Azam MA, Tripuraneni NS.

Sci Pharm. 2014 Jun 10;82(3):453-81. doi: 10.3797/scipharm.1404-08. Print 2014 Jul-Sep. Review.


Venlafaxine increases cell proliferation and regulates DISC1, PDE4B and NMDA receptor 2B expression in the hippocampus in chronic mild stress mice.

Zhang X, Li X, Li M, Ren J, Yun K, An Y, Lin L, Zhang H.

Eur J Pharmacol. 2015 May 15;755:58-65. doi: 10.1016/j.ejphar.2015.02.044. Epub 2015 Mar 11.


Expression of Phosphodiesterase 4B cAMP-Specific Gene in Subjects With Cryptorchidism and Down's Syndrome.

Salemi M, Condorelli RA, La Vignera S, Castiglione R, Salluzzo MG, Bonaccorso CM, Vinci M, Bosco P, Romano C, Campagna C, Romano C, Calogero AE.

J Clin Lab Anal. 2016 May;30(3):196-9. doi: 10.1002/jcla.21835. Epub 2014 Dec 26.


ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2.

Girgenti MJ, LoTurco JJ, Maher BJ.

PLoS One. 2012;7(2):e32404. doi: 10.1371/journal.pone.0032404. Epub 2012 Feb 27.


Association of PDE4B polymorphisms and schizophrenia in Northwestern Han Chinese.

Guan F, Zhang C, Wei S, Zhang H, Gong X, Feng J, Gao C, Su R, Yang H, Li S.

Hum Genet. 2012 Jul;131(7):1047-56. doi: 10.1007/s00439-011-1120-8. Epub 2011 Dec 11.


Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes.

Andreasen NC, Wilcox MA, Ho BC, Epping E, Ziebell S, Zeien E, Weiss B, Wassink T.

Mol Psychiatry. 2012 Nov;17(11):1093-102. doi: 10.1038/mp.2011.108. Epub 2011 Aug 30.


Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.

Moens LN, De Rijk P, Reumers J, Van den Bossche MJ, Glassee W, De Zutter S, Lenaerts AS, Nordin A, Nilsson LG, Medina Castello I, Norrback KF, Goossens D, Van Steen K, Adolfsson R, Del-Favero J.

PLoS One. 2011;6(8):e23450. doi: 10.1371/journal.pone.0023450. Epub 2011 Aug 11.


Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex.

Kuroiwa M, Snyder GL, Shuto T, Fukuda A, Yanagawa Y, Benavides DR, Nairn AC, Bibb JA, Greengard P, Nishi A.

Psychopharmacology (Berl). 2012 Feb;219(4):1065-79. doi: 10.1007/s00213-011-2436-8. Epub 2011 Aug 11.


Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice.

Lipina TV, Wang M, Liu F, Roder JC.

Neuropharmacology. 2012 Mar;62(3):1252-62. doi: 10.1016/j.neuropharm.2011.02.020. Epub 2011 Mar 2.


DISC1-binding proteins in neural development, signalling and schizophrenia.

Bradshaw NJ, Porteous DJ.

Neuropharmacology. 2012 Mar;62(3):1230-41. doi: 10.1016/j.neuropharm.2010.12.027. Epub 2010 Dec 31. Review.

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