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Items: 1 to 20 of 184

1.

PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer.

Lin X, Roy S, Jolly MK, Bocci F, Schafer NP, Tsai MY, Chen Y, He Y, Grishaev A, Weninger K, Orban J, Kulkarni P, Rangarajan G, Levine H, Onuchic JN.

J Mol Biol. 2018 May 11. pii: S0022-2836(18)30406-6. doi: 10.1016/j.jmb.2018.05.011. [Epub ahead of print]

PMID:
29758263
2.

Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy.

Tan Z, Xiao L, Tang M, Bai F, Li J, Li L, Shi F, Li N, Li Y, Du Q, Lu J, Weng X, Yi W, Zhang H, Fan J, Zhou J, Gao Q, Onuchic JN, Bode AM, Luo X, Cao Y.

Theranostics. 2018 Mar 22;8(9):2329-2347. doi: 10.7150/thno.21451. eCollection 2018.

3.

The Energetics and Physiological Impact of Cohesin Extrusion.

Vian L, Pękowska A, Rao SSP, Kieffer-Kwon KR, Jung S, Baranello L, Huang SC, El Khattabi L, Dose M, Pruett N, Sanborn AL, Canela A, Maman Y, Oksanen A, Resch W, Li X, Lee B, Kovalchuk AL, Tang Z, Nelson S, Di Pierro M, Cheng RR, Machol I, St Hilaire BG, Durand NC, Shamim MS, Stamenova EK, Onuchic JN, Ruan Y, Nussenzweig A, Levens D, Aiden EL, Casellas R.

Cell. 2018 May 17;173(5):1165-1178.e20. doi: 10.1016/j.cell.2018.03.072. Epub 2018 Apr 26.

PMID:
29706548
4.

Rotation-Activated and Cooperative Zipping Characterize Class I Viral Fusion Protein Dynamics.

Eddy NR, Onuchic JN.

Biophys J. 2018 Apr 24;114(8):1878-1888. doi: 10.1016/j.bpj.2018.03.005.

PMID:
29694865
5.

Role of metabolic spatiotemporal dynamics in regulating biofilm colony expansion.

Bocci F, Suzuki Y, Lu M, Onuchic JN.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4288-4293. doi: 10.1073/pnas.1706920115. Epub 2018 Apr 2.

PMID:
29610314
6.

NEET Proteins: A New Link Between Iron Metabolism, Reactive Oxygen Species, and Cancer.

Mittler R, Darash-Yahana M, Sohn YS, Bai F, Song L, Cabantchik IZ, Jennings PA, Onuchic JN, Nechushtai R.

Antioxid Redox Signal. 2018 Mar 29. doi: 10.1089/ars.2018.7502. [Epub ahead of print]

PMID:
29463105
7.

Fluorescent Proteins Detect Host Structural Rearrangements via Electrostatic Mechanism.

Simine L, Lammert H, Sun L, Onuchic JN, Rossky PJ.

J Am Chem Soc. 2018 Jan 31;140(4):1203-1206. doi: 10.1021/jacs.7b10851. Epub 2018 Jan 22.

PMID:
29328673
8.

Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells.

Lipper CH, Karmi O, Sohn YS, Darash-Yahana M, Lammert H, Song L, Liu A, Mittler R, Nechushtai R, Onuchic JN, Jennings PA.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):272-277. doi: 10.1073/pnas.1715842115. Epub 2017 Dec 19.

PMID:
29259115
9.

Numb prevents a complete epithelial-mesenchymal transition by modulating Notch signalling.

Bocci F, Jolly MK, Tripathi SC, Aguilar M, Hanash SM, Levine H, Onuchic JN.

J R Soc Interface. 2017 Nov;14(136). pii: 20170512. doi: 10.1098/rsif.2017.0512.

10.

De novo prediction of human chromosome structures: Epigenetic marking patterns encode genome architecture.

Di Pierro M, Cheng RR, Lieberman Aiden E, Wolynes PG, Onuchic JN.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12126-12131. doi: 10.1073/pnas.1714980114. Epub 2017 Oct 31.

11.

Molecular Simulations Suggest a Force-Dependent Mechanism of Vinculin Activation.

Sun L, Noel JK, Levine H, Onuchic JN.

Biophys J. 2017 Oct 17;113(8):1697-1710. doi: 10.1016/j.bpj.2017.08.037.

PMID:
29045864
12.

Molecular origin of the weak susceptibility of kinesin velocity to loads and its relation to the collective behavior of kinesins.

Wang Q, Diehl MR, Jana B, Cheung MS, Kolomeisky AB, Onuchic JN.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8611-E8617. doi: 10.1073/pnas.1710328114. Epub 2017 Sep 27.

13.

Cooperation between Magnesium and Metabolite Controls Collapse of the SAM-I Riboswitch.

Roy S, Onuchic JN, Sanbonmatsu KY.

Biophys J. 2017 Jul 25;113(2):348-359. doi: 10.1016/j.bpj.2017.06.044.

PMID:
28746845
14.

Modeling the response of a tumor-suppressive network to mitogenic and oncogenic signals.

Tian X, Huang B, Zhang XP, Lu M, Liu F, Onuchic JN, Wang W.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5337-5342. doi: 10.1073/pnas.1702412114. Epub 2017 May 8.

15.

Interrogating the topological robustness of gene regulatory circuits by randomization.

Huang B, Lu M, Jia D, Ben-Jacob E, Levine H, Onuchic JN.

PLoS Comput Biol. 2017 Mar 31;13(3):e1005456. doi: 10.1371/journal.pcbi.1005456. eCollection 2017 Mar.

16.

A magnesium-induced triplex pre-organizes the SAM-II riboswitch.

Roy S, Lammert H, Hayes RL, Chen B, LeBlanc R, Dayie TK, Onuchic JN, Sanbonmatsu KY.

PLoS Comput Biol. 2017 Mar 1;13(3):e1005406. doi: 10.1371/journal.pcbi.1005406. eCollection 2017 Mar.

17.

Modeling the Genetic Regulation of Cancer Metabolism: Interplay between Glycolysis and Oxidative Phosphorylation.

Yu L, Lu M, Jia D, Ma J, Ben-Jacob E, Levine H, Kaipparettu BA, Onuchic JN.

Cancer Res. 2017 Apr 1;77(7):1564-1574. doi: 10.1158/0008-5472.CAN-16-2074. Epub 2017 Feb 15.

18.

Distinguishing mechanisms underlying EMT tristability.

Jia D, Jolly MK, Tripathi SC, Den Hollander P, Huang B, Lu M, Celiktas M, Ramirez-Peña E, Ben-Jacob E, Onuchic JN, Hanash SM, Mani SA, Levine H.

Cancer Converg. 2017;1(1):2. doi: 10.1186/s41236-017-0005-8. Epub 2017 Nov 1.

19.

Pierced Lasso Topology Controls Function in Leptin.

Haglund E, Pilko A, Wollman R, Jennings PA, Onuchic JN.

J Phys Chem B. 2017 Feb 2;121(4):706-718. doi: 10.1021/acs.jpcb.6b11506. Epub 2017 Jan 18.

PMID:
28035835
20.

Elucidating the druggable interface of protein-protein interactions using fragment docking and coevolutionary analysis.

Bai F, Morcos F, Cheng RR, Jiang H, Onuchic JN.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8051-E8058. Epub 2016 Nov 29.

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