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Targeting the cell signaling pathway Keap1-Nrf2 as a therapeutic strategy for adenocarcinomas of the lung.

Zhang B, Ma Z, Tan B, Lin N.

Expert Opin Ther Targets. 2018 Dec 17. doi: 10.1080/14728222.2019.1559824. [Epub ahead of print]


Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway.

Wang J, Jiang C, Zhang K, Lan X, Chen X, Zang W, Wang Z, Guan F, Zhu C, Yang X, Lu H, Wang J.

Free Radic Biol Med. 2018 Dec 13. pii: S0891-5849(18)32261-5. doi: 10.1016/j.freeradbiomed.2018.12.014. [Epub ahead of print]


RelA driven co-expression of CXCL13 and CXCR5 is governed by a multifaceted transcriptional program regulating breast cancer progression.

Biswas S, Chowdhury SR, Mandal G, Purohit S, Gupta A, Bhattacharyya A.

Biochim Biophys Acta Mol Basis Dis. 2018 Dec 12. pii: S0925-4439(18)30488-5. doi: 10.1016/j.bbadis.2018.12.002. [Epub ahead of print]


Molecular mechanism involved in cyclophosphamide-induced cardiotoxicity: Old drug with a new vision.

Iqubal A, Iqubal MK, Sharma S, Ansari MA, Najmi AK, Ali SM, Ali J, Haque SE.

Life Sci. 2018 Dec 12. pii: S0024-3205(18)30801-4. doi: 10.1016/j.lfs.2018.12.018. [Epub ahead of print] Review.


Hepatoprotective effect of chiisanoside from Acanthopanax sessiliflorus against LPS/D-GalN-induced acute liver injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.

Bian X, Liu X, Liu J, Zhao Y, Li H, Zhang L, Li P, Gao Y.

J Sci Food Agric. 2018 Dec 15. doi: 10.1002/jsfa.9541. [Epub ahead of print]


Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB.

Illesca P, Valenzuela R, Espinosa A, Echeverría F, Soto-Alarcon S, Ortiz M, Videla LA.

Biomed Pharmacother. 2019 Jan;109:2472-2481. doi: 10.1016/j.biopha.2018.11.120. Epub 2018 Dec 1.


Traditional Chinese medicine Gegen Qinlian decoction ameliorates irinotecan chemotherapy-induced gut toxicity in mice.

Wu Y, Wang D, Yang X, Fu C, Zou L, Zhang J.

Biomed Pharmacother. 2019 Jan;109:2252-2261. doi: 10.1016/j.biopha.2018.11.095. Epub 2018 Nov 28.


Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2/ARE/glyoxalase-1 pathway mediated by phosphorylation regulation.

Liu YW, Liu XL, Kong L, Zhang MY, Chen YJ, Zhu X, Hao YC.

Biomed Pharmacother. 2019 Jan;109:2145-2154. doi: 10.1016/j.biopha.2018.11.066. Epub 2018 Nov 27.


Curcumin augments the cardioprotective effect of metformin in an experimental model of type I diabetes mellitus; Impact of Nrf2/HO-1 and JAK/STAT pathways.

Abdelsamia EM, Khaleel SA, Balah A, Abdel Baky NA.

Biomed Pharmacother. 2019 Jan;109:2136-2144. doi: 10.1016/j.biopha.2018.11.064. Epub 2018 Nov 27.


Inhibition of TREM1 reduces inflammation and oxidative stress after spinal cord injury (SCI) associated with HO-1 expressions.

Li Z, Wu F, Xu D, Zhi Z, Xu G.

Biomed Pharmacother. 2019 Jan;109:2014-2021. doi: 10.1016/j.biopha.2018.08.159. Epub 2018 Nov 26.


Apigetrin treatment attenuates LPS-induced acute otitis media though suppressing inflammation and oxidative stress.

Guo H, Li M, Xu LJ.

Biomed Pharmacother. 2019 Jan;109:1978-1987. doi: 10.1016/j.biopha.2018.07.022. Epub 2018 Nov 26.


Mate tea reduces high fat diet-induced liver and metabolic disorders in mice.

Barroso MV, Graça-Reis A, Cattani-Cavalieri I, Gitirana LB, Valenca SS, Lanzetti M.

Biomed Pharmacother. 2019 Jan;109:1547-1555. doi: 10.1016/j.biopha.2018.11.007. Epub 2018 Nov 14.


Polyamine analogue QMA attenuated ischemic injury in MCAO rats via ERK and Akt activated Nrf2/HO-1 signaling pathway.

Cen J, Zhao N, Huang WW, Liu L, Xie YY, Gan Y, Wang CJ, Ji BS.

Eur J Pharmacol. 2018 Dec 11. pii: S0014-2999(18)30713-1. doi: 10.1016/j.ejphar.2018.12.015. [Epub ahead of print]


Chalcone flavokawain A attenuates TGF-β1-induced fibrotic pathology via inhibition of ROS/Smad3 signaling pathways and induction of Nrf2/ARE-mediated antioxidant genes in vascular smooth muscle cells.

Hseu YC, Yang TY, Li ML, Rajendran P, Mathew DC, Tsai CH, Lin RW, Lee CC, Yang HL.

J Cell Mol Med. 2018 Dec 13. doi: 10.1111/jcmm.13973. [Epub ahead of print]


SIRT3 inhibited the formation of calcium oxalate-induced kidney stones through regulating NRF2/HO-1 signaling pathway.

Xi J, Jing J, Zhang Y, Liang C, Hao Z, Zhang L, Chen Y.

J Cell Biochem. 2018 Dec 12. doi: 10.1002/jcb.28109. [Epub ahead of print]


Knockdown of FOXO6 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells.

Zhou Z, Liu J, Bi C, Chen L, Jiao Y, Cui L.

J Cell Biochem. 2018 Dec 12. doi: 10.1002/jcb.28252. [Epub ahead of print]


Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.

Liu H, Dong Y, Gao Y, Zhao L, Cai C, Qi D, Zhu M, Zhao L, Liu C, Guo F, Xiao J, Huang H.

J Cell Physiol. 2018 Dec 11. doi: 10.1002/jcp.27924. [Epub ahead of print]


Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis.

Melnikov F, Botta D, White CC, Schmuck SC, Winfough M, Schaupp CM, Gallagher E, Brooks BW, Williams ES, Coish P, Anastas PT, Voutchkova A, Kostal J, Kavanagh TJ.

Chem Res Toxicol. 2018 Dec 14. doi: 10.1021/acs.chemrestox.8b00259. [Epub ahead of print]


Evaluation of Nrf2 with Exposure to Nanoparticles.

Zheng F, Li H.

Methods Mol Biol. 2019;1894:229-246. doi: 10.1007/978-1-4939-8916-4_13.


Lutzomyia longipalpis Saliva Induces Heme Oxygenase-1 Expression at Bite Sites.

Luz NF, DeSouza-Vieira T, De Castro W, Vivarini AC, Pereira L, França RR, Silveira-Mattos PS, Costa DL, Teixeira C, Meneses C, Boaventura VS, de Oliveira CI, Lopes UG, Aronson N, Andrade BB, Brodskyn CI, Valenzuela JG, Kamhawi S, Borges VM.

Front Immunol. 2018 Nov 28;9:2779. doi: 10.3389/fimmu.2018.02779. eCollection 2018.

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