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Hyperbranched Polyglycerol Derivatives as Prospective Copper Nanotransporter Candidates.

Quadir M, Fehse S, Multhaup G, Haag R.

Molecules. 2018 May 26;23(6). pii: E1281. doi: 10.3390/molecules23061281.


Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth.

Luu L, Ciccotosto GD, Vella LJ, Cheng L, Roisman LC, Multhaup G, Hill AF, Munter LM, Cappai R.

Mol Neurobiol. 2018 Apr 19. doi: 10.1007/s12035-018-1070-4. [Epub ahead of print]


Dimerization of the cellular prion protein inhibits propagation of scrapie prions.

Engelke AD, Gonsberg A, Thapa S, Jung S, Ulbrich S, Seidel R, Basu S, Multhaup G, Baier M, Engelhard M, Schätzl HM, Winklhofer KF, Tatzelt J.

J Biol Chem. 2018 May 25;293(21):8020-8031. doi: 10.1074/jbc.RA117.000990. Epub 2018 Apr 10.


APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding.

Schauenburg L, Liebsch F, Eravci M, Mayer MC, Weise C, Multhaup G.

Sci Rep. 2018 Jan 30;8(1):1916. doi: 10.1038/s41598-018-19530-8.


Dendritic Polyglycerol Sulfates in the Prevention of Synaptic Loss and Mechanism of Action on Glia.

Maysinger D, Ji J, Moquin A, Hossain S, Hancock MA, Zhang I, Chang PKY, Rigby M, Anthonisen M, Grütter P, Breitner J, McKinney RA, Reimann S, Haag R, Multhaup G.

ACS Chem Neurosci. 2018 Feb 21;9(2):260-271. doi: 10.1021/acschemneuro.7b00301. Epub 2017 Nov 10.


Direct evidence of amyloid precursor-like protein 1 trans interactions in cell-cell adhesion platforms investigated via fluorescence fluctuation spectroscopy.

Dunsing V, Mayer M, Liebsch F, Multhaup G, Chiantia S.

Mol Biol Cell. 2017 Dec 1;28(25):3609-3620. doi: 10.1091/mbc.E17-07-0459. Epub 2017 Oct 11.


Distinct age and differentiation-state dependent metabolic profiles of oligodendrocytes under optimal and stress conditions.

Rao VTS, Khan D, Cui QL, Fuh SC, Hossain S, Almazan G, Multhaup G, Healy LM, Kennedy TE, Antel JP.

PLoS One. 2017 Aug 8;12(8):e0182372. doi: 10.1371/journal.pone.0182372. eCollection 2017.


Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization.

Liebsch F, Aurousseau MRP, Bethge T, McGuire H, Scolari S, Herrmann A, Blunck R, Bowie D, Multhaup G.

J Biol Chem. 2017 Aug 11;292(32):13258-13270. doi: 10.1074/jbc.M117.779165. Epub 2017 Jun 21.


Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS.

Leonhardt J, Villela DC, Teichmann A, Münter LM, Mayer MC, Mardahl M, Kirsch S, Namsolleck P, Lucht K, Benz V, Alenina N, Daniell N, Horiuchi M, Iwai M, Multhaup G, Schülein R, Bader M, Santos RA, Unger T, Steckelings UM.

Hypertension. 2017 Jun;69(6):1128-1135. doi: 10.1161/HYPERTENSIONAHA.116.08814. Epub 2017 May 1.


Sulindac Sulfide Induces the Formation of Large Oligomeric Aggregates of the Alzheimer's Disease Amyloid-β Peptide Which Exhibit Reduced Neurotoxicity.

Prade E, Barucker C, Sarkar R, Althoff-Ospelt G, Lopez del Amo JM, Hossain S, Zhong Y, Multhaup G, Reif B.

Biochemistry. 2016 Mar 29;55(12):1839-49. doi: 10.1021/acs.biochem.5b01272. Epub 2016 Mar 9.


Amyloid precursor-like protein 1 (APLP1) exhibits stronger zinc-dependent neuronal adhesion than amyloid precursor protein and APLP2.

Mayer MC, Schauenburg L, Thompson-Steckel G, Dunsing V, Kaden D, Voigt P, Schaefer M, Chiantia S, Kennedy TE, Multhaup G.

J Neurochem. 2016 Apr;137(2):266-76. doi: 10.1111/jnc.13540. Epub 2016 Mar 7.


Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function.

Barucker C, Bittner HJ, Chang PK, Cameron S, Hancock MA, Liebsch F, Hossain S, Harmeier A, Shaw H, Charron FM, Gensler M, Dembny P, Zhuang W, Schmitz D, Rabe JP, Rao Y, Lurz R, Hildebrand PW, McKinney RA, Multhaup G.

Sci Rep. 2015 Oct 29;5:15410. doi: 10.1038/srep15410.


Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide.

Prade E, Bittner HJ, Sarkar R, Lopez Del Amo JM, Althoff-Ospelt G, Multhaup G, Hildebrand PW, Reif B.

J Biol Chem. 2015 Nov 27;290(48):28737-45. doi: 10.1074/jbc.M115.675215. Epub 2015 Sep 28.


Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles.

Multhaup G, Huber O, Buée L, Galas MC.

J Biol Chem. 2015 Sep 25;290(39):23515-22. doi: 10.1074/jbc.R115.677211. Epub 2015 Aug 21. Review.


Impact of amyloid precursor protein hydrophilic transmembrane residues on amyloid-beta generation.

Oestereich F, Bittner HJ, Weise C, Grohmann L, Janke LK, Hildebrand PW, Multhaup G, Munter LM.

Biochemistry. 2015 May 5;54(17):2777-84. doi: 10.1021/acs.biochem.5b00217. Epub 2015 Apr 23.


Polyglycerol based coatings to reduce non-specific protein adsorption in sample vials and on SPR sensors.

Becherer T, Grunewald C, Engelschalt V, Multhaup G, Risse T, Haag R.

Anal Chim Acta. 2015 Mar 31;867:47-55. doi: 10.1016/j.aca.2015.01.048. Epub 2015 Feb 10.


Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.

Dahms SO, Mayer MC, Roeser D, Multhaup G, Than ME.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):494-504. doi: 10.1107/S1399004714027114. Epub 2015 Feb 26.


Alzheimer amyloid peptide aβ42 regulates gene expression of transcription and growth factors.

Barucker C, Sommer A, Beckmann G, Eravci M, Harmeier A, Schipke CG, Brockschnieder D, Dyrks T, Althoff V, Fraser PE, Hazrati LN, George-Hyslop PS, Breitner JC, Peters O, Multhaup G.

J Alzheimers Dis. 2015;44(2):613-24. doi: 10.3233/JAD-141902.


Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.

Iulita MF, Allard S, Richter L, Munter LM, Ducatenzeiler A, Weise C, Do Carmo S, Klein WL, Multhaup G, Cuello AC.

Acta Neuropathol Commun. 2014 Jun 5;2:61. doi: 10.1186/2051-5960-2-61.


Nuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription.

Barucker C, Harmeier A, Weiske J, Fauler B, Albring KF, Prokop S, Hildebrand P, Lurz R, Heppner FL, Huber O, Multhaup G.

J Biol Chem. 2014 Jul 18;289(29):20182-91. doi: 10.1074/jbc.M114.564690. Epub 2014 May 30.

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