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A Review on the Role of miR-149-5p in the Carcinogenesis.
Ghafouri-Fard S, Khoshbakht T, Hussen BM, Kadkhoda S, Taheri M, Tafrishinejad A. Ghafouri-Fard S, et al. Int J Mol Sci. 2021 Dec 30;23(1):415. doi: 10.3390/ijms23010415. Int J Mol Sci. 2021. PMID: 35008841 Free PMC article. Review.
This miRNA is encoded by the MIR149 gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are the "guide" and the sister "passenger" strands, respectively. Deep sequencing experiments have shown higher prevalence of miR-149 …
This miRNA is encoded by the MIR149 gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are t …
MiR-149-5p: An Important miRNA Regulated by Competing Endogenous RNAs in Diverse Human Cancers.
Ren FJ, Yao Y, Cai XY, Cai YT, Su Q, Fang GY. Ren FJ, et al. Front Oncol. 2021 Oct 15;11:743077. doi: 10.3389/fonc.2021.743077. eCollection 2021. Front Oncol. 2021. PMID: 34722295 Free PMC article. Review.
Moreover, the levels of miR-149-5p are influenced by several newly discovered long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs). However, there is blank about systematic function and mechanism of miR-149-5p in human cancers. In …
Moreover, the levels of miR-149-5p are influenced by several newly discovered long non-coding RNAs (lncRNAs) and circul …
Hsa-miR-149-5p Suppresses Prostate Carcinoma Malignancy by Suppressing RGS17.
Ma J, Wei H, Li X, Qu X. Ma J, et al. Cancer Manag Res. 2021 Mar 25;13:2773-2783. doi: 10.2147/CMAR.S281968. eCollection 2021. Cancer Manag Res. 2021. PMID: 33790651 Free PMC article.
While several miRNAs have been reported to regulate the development of tumors, the molecular mechanisms and roles of miR-149-5p in prostate carcinoma (PCa) remain unclear. Our aim was to investigate the interaction and functions of miR-149-5p …
While several miRNAs have been reported to regulate the development of tumors, the molecular mechanisms and roles of miR-149- …
MiR-149-5p promotes beta-catenin-induced goat hair follicle stem cell differentiation.
Wang J, Wu X, Zhang L, Wang Q, Qu J, Wang Y, Ji D, Li Y. Wang J, et al. In Vitro Cell Dev Biol Anim. 2022 Apr;58(4):325-334. doi: 10.1007/s11626-022-00667-w. Epub 2022 Apr 14. In Vitro Cell Dev Biol Anim. 2022. PMID: 35426064
The functional studies showed that miR-149-5p overexpression markedly facilitated hair follicle stem cell differentiation, whereas inhibiting miR-149-5p inhibited hair follicle stem cell differentiation. These results more clearly elucida …
The functional studies showed that miR-149-5p overexpression markedly facilitated hair follicle stem cell differentiati …
Overexpression of miR-149-5p Attenuates Cerebral Ischemia/Reperfusion (I/R) Injury by Targeting Notch2.
Wang X, Xu Q, Wang S. Wang X, et al. Neuromolecular Med. 2022 Sep;24(3):279-289. doi: 10.1007/s12017-021-08685-9. Epub 2021 Sep 28. Neuromolecular Med. 2022. PMID: 34581980
This study aimed to investigate the roles of miR-149-5p in I/R injury. The results showed that miR-149-5p was significantly downregulated in brain tissues of rats subjected to middle cerebral artery occlusion (MCAO) and primary cortical n …
This study aimed to investigate the roles of miR-149-5p in I/R injury. The results showed that miR-149- …
Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway.
Zhang X, Wang S, Wang H, Cao J, Huang X, Chen Z, Xu P, Sun G, Xu J, Lv J, Xu Z. Zhang X, et al. Mol Cancer. 2019 Feb 4;18(1):20. doi: 10.1186/s12943-018-0935-5. Mol Cancer. 2019. PMID: 30717751 Free PMC article.
We then used a pull-down assay and dual-luciferase reporter assay to identify the downstream miR-149-5p of circNRIP1. Western blot analysis and immunofluorescence assays were performed to demonstrate that the circNRIP1-miR-149-5p-AKT1/mTO …
We then used a pull-down assay and dual-luciferase reporter assay to identify the downstream miR-149-5p of circNRIP1. W …
Macrophage miR-149-5p induction is a key driver and therapeutic target for BRONJ.
Shen X, Zhu W, Zhang P, Fu Y, Cheng J, Liu L, Xu R, Jiang H. Shen X, et al. JCI Insight. 2022 Aug 22;7(16):e159865. doi: 10.1172/jci.insight.159865. JCI Insight. 2022. PMID: 35993364 Free PMC article.
Mechanistically, ZA activated the NF-kappaB signaling pathway and then induced p65 nuclear translocation in macrophages to promote miR-149-5p transcription, resulting in impaired osteoclast differentiation via directly binding to the Traf6 3'-UTR region. More …
Mechanistically, ZA activated the NF-kappaB signaling pathway and then induced p65 nuclear translocation in macrophages to promote miR …
MiR-149-5p inhibits cell proliferation, promotes cell apoptosis and retards cell cycle of IL-22-stimulated HaCaT and NHEK keratinocytes via regulating PDE4D.
Hu W, Jiang Y, Wen C, Zeng Y, Jia M. Hu W, et al. Cytokine. 2023 Apr;164:156123. doi: 10.1016/j.cyto.2023.156123. Epub 2023 Feb 14. Cytokine. 2023. PMID: 36796259
The miR-149-5p and phosphodiesterase 4D (PDE4D) expression levels were detected by quantitative real-time PCR. ...RESULT: There was a low expression level of miR-149-5p and a high expression of PDE4D in psoriatic lesion tissues. ...
The miR-149-5p and phosphodiesterase 4D (PDE4D) expression levels were detected by quantitative real-time PCR. ...RESUL …
miR-149-5p inhibits cell proliferation and invasion through targeting GIT1 in medullary thyroid carcinoma.
Ye X, Chen X. Ye X, et al. Oncol Lett. 2019 Jan;17(1):372-378. doi: 10.3892/ol.2018.9628. Epub 2018 Oct 26. Oncol Lett. 2019. PMID: 30655777 Free PMC article.
The purpose of this study was to confirm the function of miR-149-5p in MTC and explore its downstream regulation. Moreover, miR-149-5p level in MTC was detected via RT-quantitative PCR (RT-qPCR). ...The results suggested that miR- …
The purpose of this study was to confirm the function of miR-149-5p in MTC and explore its downstream regulation. Moreo …
Effect of miR-149-5p on intramuscular fat deposition in pigs based on metabolomics and transcriptomics.
Liu Y, Wei Y, Dou Y, Li C, Song C, Zhang Z, Qi K, Li X, Qiao R, Wang K, Li X, Yang F, Han X. Liu Y, et al. BMC Genomics. 2023 May 31;24(1):293. doi: 10.1186/s12864-023-09382-6. BMC Genomics. 2023. PMID: 37259030 Free PMC article.
In vitro, foreign pigs showed increased miR-149-5p expression and reduced fat deposition when compared to Queshan Black pigs. ...In addition, the overexpression of miR-149-5p may affect the transport of Cu(2+) by targeting ATP7A and inhib …
In vitro, foreign pigs showed increased miR-149-5p expression and reduced fat deposition when compared to Queshan Black …
226 results