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An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung.

Hvorecny KL, Dolben E, Moreau-Marquis S, Hampton TH, Shabaneh TB, Flitter BA, Bahl CD, Bomberger JM, Levy BD, Stanton BA, Hogan DA, Madden DR.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L150-L156. doi: 10.1152/ajplung.00383.2017. Epub 2017 Oct 5.


Examining the social ecology of a bar-crawl: An exploratory pilot study.

Clapp JD, Madden DR, Mooney DD, Dahlquist KE.

PLoS One. 2017 Sep 27;12(9):e0185238. doi: 10.1371/journal.pone.0185238. eCollection 2017.


Optimization of the process of inverted peptides (PIPEPLUS) to screen PDZ domain ligands.

Seisel Q, Rädisch M, Gill NP, Madden DR, Boisguerin P.

Bioorg Med Chem Lett. 2017 Jul 15;27(14):3111-3116. doi: 10.1016/j.bmcl.2017.05.045. Epub 2017 May 15.


Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.

Hvorecny KL, Bahl CD, Kitamura S, Lee KSS, Hammock BD, Morisseau C, Madden DR.

Structure. 2017 May 2;25(5):697-707.e4. doi: 10.1016/j.str.2017.03.002. Epub 2017 Apr 6.


The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9.

Bertrand CA, Mitra S, Mishra SK, Wang X, Zhao Y, Pilewski JM, Madden DR, Frizzell RA.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L912-L925. doi: 10.1152/ajplung.00178.2016. Epub 2017 Mar 30.


The cif Virulence Factor Gene Is Present in Isolates From Patients With Pseudomonas aeruginosa Keratitis.

Bahl CD, St Laurent JD, Karthikeyan RS, Priya JL, Prajna L, Zegans ME, Madden DR.

Cornea. 2017 Mar;36(3):358-362. doi: 10.1097/ICO.0000000000001132.


Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators.

Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls JK, Levy BD, Madden DR, Bomberger JM.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):136-141. doi: 10.1073/pnas.1610242114. Epub 2016 Dec 15.


A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain.

Clausen RP, Mohr AØ, Riise E, Jensen AA, Gill A, Madden DR, Kastrup JS, Skottrup PD.

Int J Biol Macromol. 2016 Nov;92:779-787. doi: 10.1016/j.ijbiomac.2016.07.026. Epub 2016 Jul 8.


Rational Design of Potent and Selective Inhibitors of an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa.

Kitamura S, Hvorecny KL, Niu J, Hammock BD, Madden DR, Morisseau C.

J Med Chem. 2016 May 26;59(10):4790-9. doi: 10.1021/acs.jmedchem.6b00173. Epub 2016 May 4.


Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif.

Bahl CD, Hvorecny KL, Morisseau C, Gerber SA, Madden DR.

Biochemistry. 2016 Feb 9;55(5):788-97. doi: 10.1021/acs.biochem.5b01229. Epub 2016 Jan 22.


Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR.

Bahl CD, Hvorecny KL, Bomberger JM, Stanton BA, Hammock BD, Morisseau C, Madden DR.

Angew Chem Int Ed Engl. 2015 Aug 17;54(34):9881-5. doi: 10.1002/anie.201503983. Epub 2015 Jul 1.


A Compact Structure of Cytochrome c Trapped in a Lysine-Ligated State: Loop Refolding and Functional Implications of a Conformational Switch.

Amacher JF, Zhong F, Lisi GP, Zhu MQ, Alden SL, Hoke KR, Madden DR, Pletneva EV.

J Am Chem Soc. 2015 Jul 8;137(26):8435-49. doi: 10.1021/jacs.5b01493. Epub 2015 Jun 24.


Intracellular Delivery of Peptidyl Ligands by Reversible Cyclization: Discovery of a PDZ Domain Inhibitor that Rescues CFTR Activity.

Qian Z, Xu X, Amacher JF, Madden DR, Cormet-Boyaka E, Pei D.

Angew Chem Int Ed Engl. 2015 May 11;54(20):5874-8. doi: 10.1002/anie.201411594. Epub 2015 Mar 17.


Chemically modified peptide scaffolds target the CFTR-associated ligand PDZ domain.

Amacher JF, Zhao R, Spaller MR, Madden DR.

PLoS One. 2014 Aug 19;9(8):e103650. doi: 10.1371/journal.pone.0103650. eCollection 2014.


Serum- and glucocorticoid-induced protein kinase 1 (SGK1) increases the cystic fibrosis transmembrane conductance regulator (CFTR) in airway epithelial cells by phosphorylating Shank2E protein.

Koeppen K, Coutermarsh BA, Madden DR, Stanton BA.

J Biol Chem. 2014 Jun 13;289(24):17142-50. doi: 10.1074/jbc.M114.555599. Epub 2014 May 8.


Signature motifs identify an Acinetobacter Cif virulence factor with epoxide hydrolase activity.

Bahl CD, Hvorecny KL, Bridges AA, Ballok AE, Bomberger JM, Cady KC, O'Toole GA, Madden DR.

J Biol Chem. 2014 Mar 14;289(11):7460-9. doi: 10.1074/jbc.M113.518092. Epub 2014 Jan 28.


Stereochemical preferences modulate affinity and selectivity among five PDZ domains that bind CFTR: comparative structural and sequence analyses.

Amacher JF, Cushing PR, Brooks L 3rd, Boisguerin P, Madden DR.

Structure. 2014 Jan 7;22(1):82-93. doi: 10.1016/j.str.2013.09.019. Epub 2013 Nov 7.


Reconstitution of homomeric GluA2(flop) receptors in supported lipid membranes: functional and structural properties.

Baranovic J, Ramanujan CS, Kasai N, Midgett CR, Madden DR, Torimitsu K, Ryan JF.

J Biol Chem. 2013 Mar 22;288(12):8647-57. doi: 10.1074/jbc.M112.422105. Epub 2013 Feb 4.


Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop.

Amacher JF, Cushing PR, Bahl CD, Beck T, Madden DR.

J Biol Chem. 2013 Feb 15;288(7):5114-26. doi: 10.1074/jbc.M112.401588. Epub 2012 Dec 15.


Tissue-specific control of CFTR endocytosis by Dab2: Cargo recruitment as a therapeutic target.

Madden DR, Swiatecka-Urban A.

Commun Integr Biol. 2012 Sep 1;5(5):473-6. doi: 10.4161/cib.21375.

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