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Items: 1 to 20 of 137


Promising new antifungal treatment targeting chorismate synthase from Paracoccidioides brasiliensis.

Rodrigues-Vendramini FAV, Marschalk C, Toplak M, Macheroux P, Bonfim-Mendonça PS, Svidzinski TIE, Seixas FAV, Kioshima ES.

Antimicrob Agents Chemother. 2018 Oct 22. pii: AAC.01097-18. doi: 10.1128/AAC.01097-18. [Epub ahead of print]


Oxidative stress induced structural changes in the microtubule-associated flavoenzyme Irc15p from Saccharomyces cerevisiae.

Koch K, Strandback E, Jha S, Richter G, Bourgeois B, Madl T, Macheroux P.

Protein Sci. 2018 Sep 29. doi: 10.1002/pro.3517. [Epub ahead of print]


Oxidative cyclization of N-methyl-dopa by a fungal flavoenzyme of the amine oxidase family.

Lahham M, Pavkov-Keller T, Fuchs M, Niederhauser J, Chalhoub G, Daniel B, Kroutil W, Gruber K, Macheroux P.

J Biol Chem. 2018 Nov 2;293(44):17021-17032. doi: 10.1074/jbc.RA118.004227. Epub 2018 Sep 7.


In Situ Measurement and Correlation of Cell Density and Light Emission of Bioluminescent Bacteria.

Brodl E, Niederhauser J, Macheroux P.

J Vis Exp. 2018 Jun 28;(136). doi: 10.3791/57881.


Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases.

Heckenbichler K, Schweiger A, Brandner LA, Binter A, Toplak M, Macheroux P, Gruber K, Breinbauer R.

Angew Chem Int Ed Engl. 2018 Jun 11;57(24):7240-7244. doi: 10.1002/anie.201802962. Epub 2018 May 14.


The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase.

Toplak M, Wiedemann G, Ulićević J, Daniel B, Hoernstein SNW, Kothe J, Niederhauser J, Reski R, Winkler A, Macheroux P.

FEBS J. 2018 May;285(10):1923-1943. doi: 10.1111/febs.14458. Epub 2018 Apr 19.


Oxidation of the FAD cofactor to the 8-formyl-derivative in human electron-transferring flavoprotein.

Augustin P, Toplak M, Fuchs K, Gerstmann EC, Prassl R, Winkler A, Macheroux P.

J Biol Chem. 2018 Feb 23;293(8):2829-2840. doi: 10.1074/jbc.RA117.000846. Epub 2018 Jan 4.


Crystal structure of dipeptidyl peptidase III from the human gut symbiont Bacteroides thetaiotaomicron.

Sabljić I, Meštrović N, Vukelić B, Macheroux P, Gruber K, Luić M, Abramić M.

PLoS One. 2017 Nov 2;12(11):e0187295. doi: 10.1371/journal.pone.0187295. eCollection 2017.


Regioselective para-Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase.

Payer SE, Marshall SA, Bärland N, Sheng X, Reiter T, Dordic A, Steinkellner G, Wuensch C, Kaltwasser S, Fisher K, Rigby SEJ, Macheroux P, Vonck J, Gruber K, Faber K, Himo F, Leys D, Pavkov-Keller T, Glueck SM.

Angew Chem Int Ed Engl. 2017 Oct 23;56(44):13893-13897. doi: 10.1002/anie.201708091. Epub 2017 Oct 2.


Biosensor for the characterisation of hMAO B inhibitors and the quantification of selegiline.

Aigner M, Preissegger P, Kalcher K, Mehmeti E, Macheroux P, Edmondson D, Ortner A.

Talanta. 2017 Nov 1;174:696-702. doi: 10.1016/j.talanta.2017.06.079. Epub 2017 Jul 4.


The family of berberine bridge enzyme-like enzymes: A treasure-trove of oxidative reactions.

Daniel B, Konrad B, Toplak M, Lahham M, Messenlehner J, Winkler A, Macheroux P.

Arch Biochem Biophys. 2017 Oct 15;632:88-103. doi: 10.1016/ Epub 2017 Jul 1. Review.


Structure, biochemical and kinetic properties of recombinant Pst2p from Saccharomyces cerevisiae, a FMN-dependent NAD(P)H:quinone oxidoreductase.

Koch K, Hromic A, Sorokina M, Strandback E, Reisinger M, Gruber K, Macheroux P.

Biochim Biophys Acta Proteins Proteom. 2017 Aug;1865(8):1046-1056. doi: 10.1016/j.bbapap.2017.05.005. Epub 2017 May 10.


Evidence for the generation of myristylated FMN by bacterial luciferase.

Tabib CR, Brodl E, Macheroux P.

Mol Microbiol. 2017 Jun;104(6):1027-1036. doi: 10.1111/mmi.13676. Epub 2017 Apr 19.


Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1).

Lienhart WD, Strandback E, Gudipati V, Koch K, Binter A, Uhl MK, Rantasa DM, Bourgeois B, Madl T, Zangger K, Gruber K, Macheroux P.

FEBS J. 2017 Apr;284(8):1233-1245. doi: 10.1111/febs.14051. Epub 2017 Mar 17.


Synthesis of α,β-unsaturated aldehydes as potential substrates for bacterial luciferases.

Brodl E, Ivkovic J, Tabib CR, Breinbauer R, Macheroux P.

Bioorg Med Chem. 2017 Feb 15;25(4):1487-1495. doi: 10.1016/j.bmc.2017.01.013. Epub 2017 Jan 13.


Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability.

Tongsook C, Niederhauser J, Kronegger E, Straganz G, Macheroux P.

Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):188-199. doi: 10.1016/j.bbadis.2016.10.005. Epub 2016 Oct 18.


Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant.

Augustin P, Hromic A, Pavkov-Keller T, Gruber K, Macheroux P.

FEBS J. 2016 Oct;283(19):3587-3603. doi: 10.1111/febs.13828.


Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae.

Daniel B, Wallner S, Steiner B, Oberdorfer G, Kumar P, van der Graaff E, Roitsch T, Sensen CW, Gruber K, Macheroux P.

PLoS One. 2016 Jun 8;11(6):e0156892. doi: 10.1371/journal.pone.0156892. eCollection 2016.


Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition.

Kumar P, Reithofer V, Reisinger M, Wallner S, Pavkov-Keller T, Macheroux P, Gruber K.

Sci Rep. 2016 Mar 30;6:23787. doi: 10.1038/srep23787.


Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin.

Tongsook C, Uhl MK, Jankowitsch F, Mack M, Gruber K, Macheroux P.

FEBS J. 2016 Apr;283(8):1531-49. doi: 10.1111/febs.13690. Epub 2016 Mar 17.

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