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Items: 1 to 20 of 26

1.

Hsp70 interactions with membrane lipids regulate cellular functions in health and disease.

Balogi Z, Multhoff G, Jensen TK, Lloyd-Evans E, Yamashima T, Jäättelä M, Harwood JL, Vígh L.

Prog Lipid Res. 2019 Jan 30;74:18-30. doi: 10.1016/j.plipres.2019.01.004. [Epub ahead of print] Review.

PMID:
30710597
2.

Bi-allelic CCDC47 Variants Cause a Disorder Characterized by Woolly Hair, Liver Dysfunction, Dysmorphic Features, and Global Developmental Delay.

Morimoto M, Waller-Evans H, Ammous Z, Song X, Strauss KA, Pehlivan D, Gonzaga-Jauregui C, Puffenberger EG, Holst CR, Karaca E, Brigatti KW, Maguire E, Coban-Akdemir ZH, Amagata A, Lau CC, Chepa-Lotrea X, Macnamara E, Tos T, Isikay S, Nehrebecky M, Overton JD, Klein M, Markello TC, Posey JE, Adams DR, Lloyd-Evans E, Lupski JR, Gahl WA, Malicdan MCV.

Am J Hum Genet. 2018 Nov 1;103(5):794-807. doi: 10.1016/j.ajhg.2018.09.014. Epub 2018 Oct 25.

PMID:
30401460
3.

Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis.

Lange J, Haslett LJ, Lloyd-Evans E, Pocock JM, Sands MS, Williams BP, Cooper JD.

Acta Neuropathol Commun. 2018 Aug 8;6(1):74. doi: 10.1186/s40478-018-0575-4.

4.

Acidic Ca2+ stores in neurodegeneration.

Lloyd-Evans E.

Messenger (Los Angel). 2016 Jun 1;5(1-2):37-55. doi: 10.1166/msr.2016.1054.

5.

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.

Fineran P, Lloyd-Evans E, Lack NA, Platt N, Davis LC, Morgan AJ, Höglinger D, Tatituri RVV, Clark S, Williams IM, Tynan P, Al Eisa N, Nazarova E, Williams A, Galione A, Ory DS, Besra GS, Russell DG, Brenner MB, Sim E, Platt FM.

Wellcome Open Res. 2016 Nov 18;1:18. doi: 10.12688/wellcomeopenres.10036.2.

6.

The lysosomal storage disease continuum with ageing-related neurodegenerative disease.

Lloyd-Evans E, Haslett LJ.

Ageing Res Rev. 2016 Dec;32:104-121. doi: 10.1016/j.arr.2016.07.005. Epub 2016 Aug 8. Review.

PMID:
27516378
7.

On the move, lysosomal CAX drives Ca2+ transport and motility.

Lloyd-Evans E.

J Cell Biol. 2016 Mar 28;212(7):755-7. doi: 10.1083/jcb.201603037.

8.

Identification of dietary alanine toxicity and trafficking dysfunction in a Drosophila model of hereditary sensory and autonomic neuropathy type 1.

Oswald MC, West RJ, Lloyd-Evans E, Sweeney ST.

Hum Mol Genet. 2015 Dec 15;24(24):6899-909. doi: 10.1093/hmg/ddv390. Epub 2015 Sep 22.

9.

Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification.

Lee JH, McBrayer MK, Wolfe DM, Haslett LJ, Kumar A, Sato Y, Lie PP, Mohan P, Coffey EE, Kompella U, Mitchell CH, Lloyd-Evans E, Nixon RA.

Cell Rep. 2015 Sep 1;12(9):1430-44. doi: 10.1016/j.celrep.2015.07.050. Epub 2015 Aug 20.

10.

Regulation of TRPML1 function.

Waller-Evans H, Lloyd-Evans E.

Biochem Soc Trans. 2015 Jun;43(3):442-6. doi: 10.1042/BST20140311. Review.

PMID:
26009188
11.

Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function.

Chandrachud U, Walker MW, Simas AM, Heetveld S, Petcherski A, Klein M, Oh H, Wolf P, Zhao WN, Norton S, Haggarty SJ, Lloyd-Evans E, Cotman SL.

J Biol Chem. 2015 Jun 5;290(23):14361-80. doi: 10.1074/jbc.M114.621706. Epub 2015 Apr 15.

12.

A rapid method for the preparation of ultrapure, functional lysosomes using functionalized superparamagnetic iron oxide nanoparticles.

Walker MW, Lloyd-Evans E.

Methods Cell Biol. 2015;126:21-43. doi: 10.1016/bs.mcb.2014.10.019. Epub 2015 Jan 19.

PMID:
25665439
13.

Disorders of cholesterol metabolism and their unanticipated convergent mechanisms of disease.

Platt FM, Wassif C, Colaco A, Dardis A, Lloyd-Evans E, Bembi B, Porter FD.

Annu Rev Genomics Hum Genet. 2014;15:173-94. doi: 10.1146/annurev-genom-091212-153412.

14.

Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease.

Morgan AJ, Platt FM, Lloyd-Evans E, Galione A.

Biochem J. 2011 Nov 1;439(3):349-74. doi: 10.1042/BJ20110949. Review.

PMID:
21992097
15.

Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases.

Lloyd-Evans E, Platt FM.

Cell Calcium. 2011 Aug;50(2):200-5. doi: 10.1016/j.ceca.2011.03.010. Epub 2011 Jul 2. Review.

PMID:
21724254
16.

Endolysosomal calcium regulation and disease.

Lloyd-Evans E, Waller-Evans H, Peterneva K, Platt FM.

Biochem Soc Trans. 2010 Dec;38(6):1458-64. doi: 10.1042/BST0381458. Review.

PMID:
21118107
17.

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.

Ruas M, Rietdorf K, Arredouani A, Davis LC, Lloyd-Evans E, Koegel H, Funnell TM, Morgan AJ, Ward JA, Watanabe K, Cheng X, Churchill GC, Zhu MX, Platt FM, Wessel GM, Parrington J, Galione A.

Curr Biol. 2010 Apr 27;20(8):703-9. doi: 10.1016/j.cub.2010.02.049. Epub 2010 Mar 25.

18.

Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease.

Lloyd-Evans E, Platt FM.

Traffic. 2010 Apr;11(4):419-28. doi: 10.1111/j.1600-0854.2010.01032.x. Epub 2010 Jan 6. Review.

19.

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.

Lloyd-Evans E, Morgan AJ, He X, Smith DA, Elliot-Smith E, Sillence DJ, Churchill GC, Schuchman EH, Galione A, Platt FM.

Nat Med. 2008 Nov;14(11):1247-55. doi: 10.1038/nm.1876. Epub 2008 Oct 26.

PMID:
18953351
20.

Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis.

Elliot-Smith E, Speak AO, Lloyd-Evans E, Smith DA, van der Spoel AC, Jeyakumar M, Butters TD, Dwek RA, d'Azzo A, Platt FM.

Mol Genet Metab. 2008 Jun;94(2):204-11. doi: 10.1016/j.ymgme.2008.02.005. Epub 2008 Apr 1.

PMID:
18387328

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