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Prognostic significance of NAB2-STAT6 fusion variants and TERT promotor mutations in solitary fibrous tumors/hemangiopericytomas of the CNS: not (yet) clear.

Vogels R, Macagno N, Griewank K, Groenen P, Verdijk M, Fonville J, Kusters B; French CNS SFT/HPC Consortium; Dutch CNS SFT/HPC Consortium, Figarella-Branger D, Wesseling P, Bouvier C, Flucke U.

Acta Neuropathol. 2019 Apr;137(4):679-682. doi: 10.1007/s00401-019-01968-3. Epub 2019 Feb 2. No abstract available.


Influence of pretreatment growth rate on Gamma Knife treatment response for vestibular schwannoma: a volumetric analysis.

Langenhuizen PPJH, Zinger S, Hanssens PEJ, Kunst HPM, Mulder JJS, Leenstra S, de With PHN, Verheul JB.

J Neurosurg. 2018 Nov 1:1-8. doi: 10.3171/2018.6.JNS18516. [Epub ahead of print]


Gamma knife radiosurgery for recurrent gliomas.

Sadik ZHA, Hanssens PEJ, Verheul JB, Beute GN, Te Lie S, Leenstra S, Ardon H.

J Neurooncol. 2018 Dec;140(3):615-622. doi: 10.1007/s11060-018-2988-0. Epub 2018 Sep 6.


Determination of Site-Specific Phosphorylation Ratios in Proteins with Targeted Mass Spectrometry.

Dekker LJM, Zeneyedpour L, Snoeijers S, Joore J, Leenstra S, Luider TM.

J Proteome Res. 2018 Apr 6;17(4):1654-1663. doi: 10.1021/acs.jproteome.7b00911. Epub 2018 Mar 9.


Volumetric changes and clinical outcome for petroclival meningiomas after primary treatment with Gamma Knife radiosurgery.

Sadik ZHA, Lie ST, Leenstra S, Hanssens PEJ.

J Neurosurg. 2018 Dec 1;129(6):1623-1629. doi: 10.3171/2017.7.JNS17380.


Retreatment of vestibular schwannoma with Gamma Knife radiosurgery: clinical outcome, tumor control, and review of literature.

Fu VX, Verheul JB, Beute GN, Leenstra S, Kunst HPM, Mulder JJS, Hanssens PEJ.

J Neurosurg. 2018 Jul;129(1):137-145. doi: 10.3171/2017.3.JNS162033. Epub 2017 Oct 6.


Ultrasound Aided Vertebral Level Localization for Lumbar Surgery.

Baka N, Leenstra S, van Walsum T.

IEEE Trans Med Imaging. 2017 Oct;36(10):2138-2147. doi: 10.1109/TMI.2017.2738612. Epub 2017 Aug 10.


Random Forest-Based Bone Segmentation in Ultrasound.

Baka N, Leenstra S, van Walsum T.

Ultrasound Med Biol. 2017 Oct;43(10):2426-2437. doi: 10.1016/j.ultrasmedbio.2017.04.022. Epub 2017 Jul 21.


The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8+T Cell Anti-tumor Activity.

Kleijn A, van den Bossche W, Haefner ES, Belcaid Z, Burghoorn-Maas C, Kloezeman JJ, Pas SD, Leenstra S, Debets R, de Vrij J, Dirven CMF, Lamfers MLM.

Mol Ther Oncolytics. 2017 Mar 1;5:11-19. doi: 10.1016/j.omto.2017.02.002. eCollection 2017 Jun 16.


Does early resection of presumed low-grade glioma improve survival? A clinical perspective.

Wijnenga MMJ, Mattni T, French PJ, Rutten GJ, Leenstra S, Kloet F, Taphoorn MJB, van den Bent MJ, Dirven CMF, van Veelen ML, Vincent AJPE.

J Neurooncol. 2017 May;133(1):137-146. doi: 10.1007/s11060-017-2418-8. Epub 2017 Apr 11.


Treatment of Nonfunctional Pituitary Adenoma Postoperative Remnants: Adjuvant or Delayed Gamma Knife Radiosurgery?

Sadik ZHA, Voormolen EHJ, Depauw PRAM, Burhani B, Nieuwlaat WA, Verheul J, Leenstra S, Fleischeuer R, Hanssens PEJ.

World Neurosurg. 2017 Apr;100:361-368. doi: 10.1016/j.wneu.2017.01.028. Epub 2017 Jan 18.


TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2.

Venkatesan S, Hoogstraat M, Caljouw E, Pierson T, Spoor JK, Zeneyedpour L, Dubbink HJ, Dekker LJ, van der Kaaij M, Kloezeman J, Berghauser Pont LM, Besselink NJ, Luider TM, Joore J, Martens JW, Lamfers ML, Sleijfer S, Leenstra S.

Oncotarget. 2016 Sep 6;7(36):58435-58444. doi: 10.18632/oncotarget.11205.


Malignant Glioma In Vitro Models: On the Utilization of Stem-like Cells.

Balvers RK, Dirven CM, Leenstra S, Lamfers ML.

Curr Cancer Drug Targets. 2017;17(3):255-266. doi: 10.2174/1568009616666160813191809. Review.


A Systematic Comparison Identifies an ATP-Based Viability Assay as Most Suitable Read-Out for Drug Screening in Glioma Stem-Like Cells.

Kleijn A, Kloezeman JJ, Balvers RK, van der Kaaij M, Dirven CM, Leenstra S, Lamfers ML.

Stem Cells Int. 2016;2016:5623235. doi: 10.1155/2016/5623235. Epub 2016 May 5.


Genetic biomarkers of drug response for small-molecule therapeutics targeting the RTK/Ras/PI3K, p53 or Rb pathway in glioblastoma.

Venkatesan S, Lamfers ML, Dirven CM, Leenstra S.

CNS Oncol. 2016;5(2):77-90. doi: 10.2217/cns-2015-0005. Epub 2016 Mar 17. Review. Erratum in: CNS Oncol. 2016 Jul;5(3):188.


Gamma Knife radiosurgery for vestibular schwannomas: evaluation of tumor control and its predictors in a large patient cohort in The Netherlands.

Klijn S, Verheul JB, Beute GN, Leenstra S, Mulder JJ, Kunst HP, Hanssens PE.

J Neurosurg. 2016 Jun;124(6):1619-26. doi: 10.3171/2015.4.JNS142415. Epub 2015 Oct 2.


In vitro screening of clinical drugs identifies sensitizers of oncolytic viral therapy in glioblastoma stem-like cells.

Berghauser Pont LM, Balvers RK, Kloezeman JJ, Nowicki MO, van den Bossche W, Kremer A, Wakimoto H, van den Hoogen BG, Leenstra S, Dirven CM, Chiocca EA, Lawler SE, Lamfers ML.

Gene Ther. 2015 Dec;22(12):947-59. doi: 10.1038/gt.2015.72. Epub 2015 Jul 21.


The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells.

Berghauser Pont LM, Kleijn A, Kloezeman JJ, van den Bossche W, Kaufmann JK, de Vrij J, Leenstra S, Dirven CM, Lamfers ML.

PLoS One. 2015 May 18;10(5):e0127058. doi: 10.1371/journal.pone.0127058. eCollection 2015.


The therapeutic efficacy of the oncolytic virus Delta24-RGD in a murine glioma model depends primarily on antitumor immunity.

Kleijn A, Kloezeman J, Treffers-Westerlaken E, Fulci G, Leenstra S, Dirven C, Debets R, Lamfers M.

Oncoimmunology. 2014 Dec 13;3(9):e955697. eCollection 2014 Oct.


ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells.

Balvers RK, Lamfers ML, Kloezeman JJ, Kleijn A, Berghauser Pont LM, Dirven CM, Leenstra S.

J Transl Med. 2015 Feb 26;13:74. doi: 10.1186/s12967-015-0427-y.

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