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Items: 1 to 20 of 145

1.

Non-covalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity.

Kim JY, Kinoshita M, Kume S, Gt H, Sugiki T, Ladbury JE, Kojima C, Ikegami T, Kurisu G, Goto Y, Hase T, Lee YH.

Biochem J. 2016 Nov 1;473(21):3837-3854. Epub 2016 Aug 22.

PMID:
27551107
2.

Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43.

Belousova N, Mikheeva G, Xiong C, Stagg LJ, Gagea M, Fox PS, Bassett RL, Ladbury JE, Braun MB, Stehle T, Li C, Krasnykh V.

Oncotarget. 2016 Aug 16;7(33):53414-53429. doi: 10.18632/oncotarget.10800.

3.

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network.

Carter BZ, Mak PY, Chen Y, Mak DH, Mu H, Jacamo R, Ruvolo V, Arold ST, Ladbury JE, Burks JK, Kornblau S, Andreeff M.

Oncotarget. 2016 Apr 12;7(15):20054-67. doi: 10.18632/oncotarget.7911.

4.

Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.

Campbell JC, Kim JJ, Li KY, Huang GY, Reger AS, Matsuda S, Sankaran B, Link TM, Yuasa K, Ladbury JE, Casteel DE, Kim C.

J Biol Chem. 2016 Mar 11;291(11):5623-33. doi: 10.1074/jbc.M115.691303. Epub 2016 Jan 14.

5.

Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma.

Timsah Z, Berrout J, Suraokar M, Behrens C, Song J, Lee JJ, Ivan C, Gagea M, Shires M, Hu X, Vallien C, Kingsley CV, Wistuba I, Ladbury JE.

Am J Cancer Res. 2015 Sep 15;5(10):3135-48. eCollection 2015.

6.

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response.

Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, Morelli MP, Sen M, Ladbury JE, Chen CH, Grandis JR, Kopetz S, Hung MC.

J Clin Invest. 2015 Dec;125(12):4529-43. doi: 10.1172/JCI82826. Epub 2015 Nov 16.

7.

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity.

Mandal PK, Morlacchi P, Knight JM, Link TM, Lee GR 4th, Nurieva R, Singh D, Dhanik A, Kavraki L, Corry DB, Ladbury JE, McMurray JS.

J Med Chem. 2015 Nov 25;58(22):8970-84. doi: 10.1021/acs.jmedchem.5b01321. Epub 2015 Nov 9.

8.

Erythropoietin Stimulates Tumor Growth via EphB4.

Pradeep S, Huang J, Mora EM, Nick AM, Cho MS, Wu SY, Noh K, Pecot CV, Rupaimoole R, Stein MA, Brock S, Wen Y, Xiong C, Gharpure K, Hansen JM, Nagaraja AS, Previs RA, Vivas-Mejia P, Han HD, Hu W, Mangala LS, Zand B, Stagg LJ, Ladbury JE, Ozpolat B, Alpay SN, Nishimura M, Stone RL, Matsuo K, Armaiz-Peña GN, Dalton HJ, Danes C, Goodman B, Rodriguez-Aguayo C, Kruger C, Schneider A, Haghpeykar S, Jaladurgam P, Hung MC, Coleman RL, Liu J, Li C, Urbauer D, Lopez-Berestein G, Jackson DB, Sood AK.

Cancer Cell. 2015 Nov 9;28(5):610-22. doi: 10.1016/j.ccell.2015.09.008. Epub 2015 Oct 17.

9.

Corrigendum: Grb2 monomer-dimer equilibrium determines normal versus oncogenic function.

Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee Iv GR, Lin CC, Gagea M, Marti AA, Ladbury JE.

Nat Commun. 2015 Aug 3;6:8007. doi: 10.1038/ncomms9007. No abstract available.

PMID:
26234419
10.

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.

Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GN, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, Lopez-Berestein G, Hung MC, Sood AK, Bogdanov M, Ladbury JE.

Oncogene. 2016 Apr 28;35(17):2186-96. doi: 10.1038/onc.2015.279. Epub 2015 Jul 27.

11.

T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.

Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M.

Nat Immunol. 2015 Sep;16(9):970-9. doi: 10.1038/ni.3211. Epub 2015 Jul 13.

12.

Grb2 monomer-dimer equilibrium determines normal versus oncogenic function.

Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee GR 4th, Lin CC, Gagea M, Marti AA, Ladbury JE.

Nat Commun. 2015 Jun 24;6:7354. doi: 10.1038/ncomms8354. Erratum in: Nat Commun. 2015;6:8007.

13.

A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin.

Davlieva M, Shi Y, Leonard PG, Johnson TA, Zianni MR, Arias CA, Ladbury JE, Shamoo Y.

Nucleic Acids Res. 2015 May 19;43(9):4758-73. doi: 10.1093/nar/gkv321. Epub 2015 Apr 19.

14.

A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis.

Bagheri-Yarmand R, Sinha KM, Gururaj AE, Ahmed Z, Rizvi YQ, Huang SC, Ladbury JE, Bogler O, Williams MD, Cote GJ, Gagel RF.

J Biol Chem. 2015 May 1;290(18):11749-61. doi: 10.1074/jbc.M114.619833. Epub 2015 Mar 20.

15.

A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans.

Drake M, Furuta T, Suen KM, Gonzalez G, Liu B, Kalia A, Ladbury JE, Fire AZ, Skeath JB, Arur S.

Dev Cell. 2014 Dec 8;31(5):614-28. doi: 10.1016/j.devcel.2014.11.004.

16.

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.

Poncet-Montange G, Zhan Y, Bardenhagen JP, Petrocchi A, Leo E, Shi X, Lee GR 4th, Leonard PG, Geck Do MK, Cardozo MG, Andersen JN, Palmer WS, Jones P, Ladbury JE.

Biochem J. 2015 Mar 1;466(2):337-46. doi: 10.1042/BJ20140933.

17.

HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer.

Boulbes DR, Arold ST, Chauhan GB, Blachno KV, Deng N, Chang WC, Jin Q, Huang TH, Hsu JM, Brady SW, Bartholomeusz C, Ladbury JE, Stone S, Yu D, Hung MC, Esteva FJ.

Mol Oncol. 2015 Mar;9(3):586-600. doi: 10.1016/j.molonc.2014.10.011. Epub 2014 Nov 11.

18.

Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.

Dudutienė V, Matulienė J, Smirnov A, Timm DD, Zubrienė A, Baranauskienė L, Morkūnaite V, Smirnovienė J, Michailovienė V, Juozapaitienė V, Mickevičiūtė A, Kazokaitė J, Bakšytė S, Kasiliauskaitė A, Jachno J, Revuckienė J, Kišonaitė M, Pilipuitytė V, Ivanauskaitė E, Milinavičiūtė G, Smirnovas V, Petrikaitė V, Kairys V, Petrauskas V, Norvaišas P, Lingė D, Gibieža P, Capkauskaitė E, Zakšauskas A, Kazlauskas E, Manakova E, Gražulis S, Ladbury JE, Matulis D.

J Med Chem. 2014 Nov 26;57(22):9435-46. doi: 10.1021/jm501003k. Epub 2014 Nov 10.

PMID:
25358084
19.

The toolbox is open, but who should pay for the job?

Ladbury JE, Hall A, Skidmore J.

Nat Rev Drug Discov. 2014 Jul;13(7):479-80. doi: 10.1038/nrd4367. No abstract available.

PMID:
24981345
20.

(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus.

Aramini JM, Hamilton K, Ma LC, Swapna GVT, Leonard PG, Ladbury JE, Krug RM, Montelione GT.

Structure. 2014 Apr 8;22(4):515-525. doi: 10.1016/j.str.2014.01.010. Epub 2014 Feb 27.

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