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Schizophr Res. 2010 May;118(1-3):113-7. doi: 10.1016/j.schres.2010.01.014. Epub 2010 Feb 11.

Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population.

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Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.


The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.

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