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Items: 1 to 20 of 278


In vitro validation of in silico identified inhibitory interactions.

Liu H, Bridges D, Randall C, Solla SA, Wu B, Hansma P, Yan X, Kosik KS, Bouchard K.

J Neurosci Methods. 2019 Apr 6;321:39-48. doi: 10.1016/j.jneumeth.2019.04.002. [Epub ahead of print]


Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions.

Lin Y, McCarty J, Rauch JN, Delaney KT, Kosik KS, Fredrickson GH, Shea JE, Han S.

Elife. 2019 Apr 5;8. pii: e42571. doi: 10.7554/eLife.42571.


A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.

Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate AM, Fisher SK, Cuervo AM, Kosik KS.

Sci Transl Med. 2019 Mar 27;11(485). pii: eaat3005. doi: 10.1126/scitranslmed.aat3005.


iPSCs-derived nerve-like cells from familial Alzheimer's disease PSEN 1 E280A reveal increased amyloid-beta levels and loss of the Y chromosome.

Mendivil-Perez M, Velez-Pardo C, Kosik KS, Lopera F, Jimenez-Del-Rio M.

Neurosci Lett. 2019 Mar 20;703:111-118. doi: 10.1016/j.neulet.2019.03.032. [Epub ahead of print]


Non-contact monitoring of extra-cellular field potentials with a multi-electrode array.

Sharf T, Hansma PK, Hari MA, Kosik KS.

Lab Chip. 2019 Apr 9;19(8):1448-1457. doi: 10.1039/c8lc00984h.


Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer's Disease: A Comprehensive Review of the Colombian Kindred.

Fuller JT, Cronin-Golomb A, Gatchel JR, Norton DJ, Guzmán-Vélez E, Jacobs HIL, Hanseeuw B, Pardilla-Delgado E, Artola A, Baena A, Bocanegra Y, Kosik KS, Chen K, Tariot PN, Johnson K, Sperling RA, Reiman EM, Lopera F, Quiroz YT.

J Prev Alzheimers Dis. 2019;6(2):112-120. doi: 10.14283/jpad.2019.6.


Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr).

Ramirez Aguilar L, Acosta-Uribe J, Giraldo MM, Moreno S, Baena A, Alzate D, Cuastumal R, Aguillón D, Madrigal L, Saldarriaga A, Navarro A, Garcia GP, Aguirre-Acevedo DC, Geier EG, Cochran JN, Quiroz YT, Myers RM, Yokoyama JS, Kosik KS, Lopera F.

Alzheimers Dement. 2019 Feb 8. pii: S1552-5260(18)33627-6. doi: 10.1016/j.jalz.2018.12.010. [Epub ahead of print]


Cell biology in support of neurological research: 2018 highlights.

Kosik KS.

Lancet Neurol. 2019 Jan;18(1):19-20. doi: 10.1016/S1474-4422(18)30462-9. No abstract available.


Cofactors are essential constituents of stable and seeding-active tau fibrils.

Fichou Y, Lin Y, Rauch JN, Vigers M, Zeng Z, Srivastava M, Keller TJ, Freed JH, Kosik KS, Han S.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13234-13239. doi: 10.1073/pnas.1810058115. Epub 2018 Dec 11.


Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development.

Nowakowski TJ, Rani N, Golkaram M, Zhou HR, Alvarado B, Huch K, West JA, Leyrat A, Pollen AA, Kriegstein AR, Petzold LR, Kosik KS.

Nat Neurosci. 2018 Dec;21(12):1784-1792. doi: 10.1038/s41593-018-0265-3. Epub 2018 Nov 19.


Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).

Rauch JN, Chen JJ, Sorum AW, Miller GM, Sharf T, See SK, Hsieh-Wilson LC, Kampmann M, Kosik KS.

Sci Rep. 2018 Apr 23;8(1):6382. doi: 10.1038/s41598-018-24904-z.


Action potential propagation recorded from single axonal arbors using multielectrode arrays.

Tovar KR, Bridges DC, Wu B, Randall C, Audouard M, Jang J, Hansma PK, Kosik KS.

J Neurophysiol. 2018 Jul 1;120(1):306-320. doi: 10.1152/jn.00659.2017. Epub 2018 Apr 11.


Evolution of New miRNAs and Cerebro-Cortical Development.

Kosik KS, Nowakowski T.

Annu Rev Neurosci. 2018 Jul 8;41:119-137. doi: 10.1146/annurev-neuro-080317-061822. Epub 2018 Apr 4.


MEA Viewer: A high-performance interactive application for visualizing electrophysiological data.

Bridges DC, Tovar KR, Wu B, Hansma PK, Kosik KS.

PLoS One. 2018 Feb 9;13(2):e0192477. doi: 10.1371/journal.pone.0192477. eCollection 2018.


iPhemap: an atlas of phenotype to genotype relationships of human iPSC models of neurological diseases.

Hollingsworth EW, Vaughn JE, Orack JC, Skinner C, Khouri J, Lizarraga SB, Hester ME, Watanabe F, Kosik KS, Imitola J.

EMBO Mol Med. 2017 Dec;9(12):1742-1762. doi: 10.15252/emmm.201708191.


The Role of Chromatin Density in Cell Population Heterogeneity during Stem Cell Differentiation.

Golkaram M, Jang J, Hellander S, Kosik KS, Petzold LR.

Sci Rep. 2017 Oct 17;7(1):13307. doi: 10.1038/s41598-017-13731-3.


A molecular signature for anastasis, recovery from the brink of apoptotic cell death.

Sun G, Guzman E, Balasanyan V, Conner CM, Wong K, Zhou HR, Kosik KS, Montell DJ.

J Cell Biol. 2017 Oct 2;216(10):3355-3368. doi: 10.1083/jcb.201706134. Epub 2017 Aug 2.


Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury.

Lisi V, Singh B, Giroux M, Guzman E, Painter MW, Cheng YC, Huebner E, Coppola G, Costigan M, Woolf CJ, Kosik KS.

Cell Rep. 2017 Aug 1;20(5):1136-1147. doi: 10.1016/j.celrep.2017.07.010.


RNA stores tau reversibly in complex coacervates.

Zhang X, Lin Y, Eschmann NA, Zhou H, Rauch JN, Hernandez I, Guzman E, Kosik KS, Han S.

PLoS Biol. 2017 Jul 6;15(7):e2002183. doi: 10.1371/journal.pbio.2002183. eCollection 2017 Jul.


A microRNA-mRNA expression network during oral siphon regeneration in Ciona.

Spina EJ, Guzman E, Zhou H, Kosik KS, Smith WC.

Development. 2017 May 15;144(10):1787-1797. doi: 10.1242/dev.144097. Epub 2017 Apr 21.

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