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Items: 1 to 20 of 69

1.

ABNORMAL ABSORPTIVE COLONIC MOTOR ACTIVITY IN GERM FREE MICE IS RECTIFIED BY BUTYRATE, AN EFFECT POSSIBLY MEDIATED BY MUCOSAL SEROTONIN.

Vincent AD, Wang XY, Parsons SP, Khan WI, Huizinga JD.

Am J Physiol Gastrointest Liver Physiol. 2018 Aug 10. doi: 10.1152/ajpgi.00237.2017. [Epub ahead of print]

PMID:
30095295
2.

Serotonin in the gut: Blessing or a curse.

Banskota S, Ghia JE, Khan WI.

Biochimie. 2018 Jun 14. pii: S0300-9084(18)30165-2. doi: 10.1016/j.biochi.2018.06.008. [Epub ahead of print] Review.

PMID:
29909048
3.

Inflammation-related differences in mucosa-associated microbiota and intestinal barrier function in colonic Crohn's disease.

Libertucci J, Dutta U, Kaur S, Jury J, Rossi L, Fontes ME, Shajib MS, Khan WI, Surette MG, Verdu EF, Armstrong D.

Am J Physiol Gastrointest Liver Physiol. 2018 Sep 1;315(3):G420-G431. doi: 10.1152/ajpgi.00411.2017. Epub 2018 May 31.

PMID:
29848021
4.

Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.

Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1550-E1559. doi: 10.1073/pnas.1720553115. Epub 2018 Jan 31.

5.

Loss-of-function mutations in ADCY3 cause monogenic severe obesity.

Saeed S, Bonnefond A, Tamanini F, Mirza MU, Manzoor J, Janjua QM, Din SM, Gaitan J, Milochau A, Durand E, Vaillant E, Haseeb A, De Graeve F, Rabearivelo I, Sand O, Queniat G, Boutry R, Schott DA, Ayesha H, Ali M, Khan WI, Butt TA, Rinne T, Stumpel C, Abderrahmani A, Lang J, Arslan M, Froguel P.

Nat Genet. 2018 Feb;50(2):175-179. doi: 10.1038/s41588-017-0023-6. Epub 2018 Jan 8.

6.

Comparison of Fecal Calprotectin Methods for Predicting Relapse of Pediatric Inflammatory Bowel Disease.

Kittanakom S, Shajib MS, Garvie K, Turner J, Brooks D, Odeh S, Issenman R, Chetty VT, Macri J, Khan WI.

Can J Gastroenterol Hepatol. 2017;2017:1450970. doi: 10.1155/2017/1450970. Epub 2017 Apr 16.

7.

Diverse Effects of Gut-Derived Serotonin in Intestinal Inflammation.

Shajib MS, Baranov A, Khan WI.

ACS Chem Neurosci. 2017 May 17;8(5):920-931. doi: 10.1021/acschemneuro.6b00414. Epub 2017 Mar 27. Review.

PMID:
28288510
8.

Different Th17 immunity in gut, liver, and adipose tissues during obesity: the role of diet, genetics, and microbes.

Cavallari JF, Denou E, Foley KP, Khan WI, Schertzer JD.

Gut Microbes. 2016;7(1):82-9. doi: 10.1080/19490976.2015.1127481.

9.

Fecal calprotectin: its scope and utility in the management of inflammatory bowel disease.

Ikhtaire S, Shajib MS, Reinisch W, Khan WI.

J Gastroenterol. 2016 May;51(5):434-46. doi: 10.1007/s00535-016-1182-4. Epub 2016 Feb 20. Review.

PMID:
26897740
10.

New Role of Nod Proteins in Regulation of Intestinal Goblet Cell Response in the Context of Innate Host Defense in an Enteric Parasite Infection.

Wang H, Kim JJ, Denou E, Gallagher A, Thornton DJ, Shajib MS, Xia L, Schertzer JD, Grencis RK, Philpott DJ, Khan WI.

Infect Immun. 2015 Nov 2;84(1):275-85. doi: 10.1128/IAI.01187-15. Print 2016 Jan.

11.

Overlap Chronic Placental Inflammation Is Associated with a Unique Gene Expression Pattern.

Raman K, Wang H, Troncone MJ, Khan WI, Pare G, Terry J.

PLoS One. 2015 Jul 24;10(7):e0133738. doi: 10.1371/journal.pone.0133738. eCollection 2015.

12.

Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.

Kim JJ, Wang H, Terc JD, Zambrowicz B, Yang QM, Khan WI.

Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G455-65. doi: 10.1152/ajpgi.00299.2014. Epub 2015 Jul 23.

13.

Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance.

Denou E, Lolmède K, Garidou L, Pomie C, Chabo C, Lau TC, Fullerton MD, Nigro G, Zakaroff-Girard A, Luche E, Garret C, Serino M, Amar J, Courtney M, Cavallari JF, Henriksbo BD, Barra NG, Foley KP, McPhee JB, Duggan BM, O'Neill HM, Lee AJ, Sansonetti P, Ashkar AA, Khan WI, Surette MG, Bouloumié A, Steinberg GR, Burcelin R, Schertzer JD.

EMBO Mol Med. 2015 Mar;7(3):259-74. doi: 10.15252/emmm.201404169.

14.

5-HT7 receptor signaling: improved therapeutic strategy in gut disorders.

Kim JJ, Khan WI.

Front Behav Neurosci. 2014 Dec 11;8:396. doi: 10.3389/fnbeh.2014.00396. eCollection 2014. Review.

15.

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis.

Crane JD, Palanivel R, Mottillo EP, Bujak AL, Wang H, Ford RJ, Collins A, Blümer RM, Fullerton MD, Yabut JM, Kim JJ, Ghia JE, Hamza SM, Morrison KM, Schertzer JD, Dyck JR, Khan WI, Steinberg GR.

Nat Med. 2015 Feb;21(2):166-72. doi: 10.1038/nm.3766. Epub 2014 Dec 8.

16.

The role of serotonin and its receptors in activation of immune responses and inflammation.

Shajib MS, Khan WI.

Acta Physiol (Oxf). 2015 Mar;213(3):561-74. doi: 10.1111/apha.12430. Epub 2014 Dec 11. Review.

PMID:
25439045
17.

Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis.

Flannigan KL, Agbor TA, Blackler RW, Kim JJ, Khan WI, Verdu EF, Ferraz JG, Wallace JL.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13559-64. doi: 10.1073/pnas.1413390111. Epub 2014 Sep 3.

18.

Phenotypic severity of homozygous GCK mutations causing neonatal or childhood-onset diabetes is primarily mediated through effects on protein stability.

Raimondo A, Chakera AJ, Thomsen SK, Colclough K, Barrett A, De Franco E, Chatelas A, Demirbilek H, Akcay T, Alawneh H; International NDM Consortium, Flanagan SE, Van De Bunt M, Hattersley AT, Gloyn AL, Ellard S; International NDM Consortium.

Hum Mol Genet. 2014 Dec 15;23(24):6432-40. doi: 10.1093/hmg/ddu360. Epub 2014 Jul 11.

19.

T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes.

Chu DK, Mohammed-Ali Z, Jiménez-Saiz R, Walker TD, Goncharova S, Llop-Guevara A, Kong J, Gordon ME, Barra NG, Gillgrass AE, Van Seggelen H, Khan WI, Ashkar AA, Bramson JL, Humbles AA, Kolbeck R, Waserman S, Jordana M.

Mucosal Immunol. 2014 Nov;7(6):1395-404. doi: 10.1038/mi.2014.29. Epub 2014 Apr 30.

PMID:
24781052
20.

The Role of 5-HT Dysregulation in Inflammatory Bowel Disease.

Khan WI.

Gastroenterol Hepatol (N Y). 2013 Apr;9(4):259-61. No abstract available.

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