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Clin Exp Rheumatol. 2010 Sep-Oct;28(5 Suppl 61):S132-7. Epub 2010 Oct 28.

Use of methotrexate in patients with psoriatic arthritis.

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Division of Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA 92037-0943, USA.


Despite a paucity of high quality clinical data, methotrexate (MTX) remains one of the most commonly used medications in the treatment of patients with psoriatic arthritis (PsA). This report addresses mechanistic rationale, available clinical evidence, safety considerations, and a potential research agenda regarding the use of MTX in the management of PsA.

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