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See also: spas (SPASTIN) spastin in the Gene database
spastin in Drosophila melanogasterZeugodacus cucurbitaeExaiptasia pallidaAll 6 Gene records
Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation.
Vemu A, Szczesna E, Zehr EA, Spector JO, Grigorieff N, Deaconescu AM, Roll-Mecak A.
Science. 2018 Aug 24;361(6404). pii: eaau1504. doi: 10.1126/science.aau1504.
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Katanin spiral and ring structures shed light on power stroke for microtubule severing.
Zehr E, Szyk A, Piszczek G, Szczesna E, Zuo X, Roll-Mecak A.
Nat Struct Mol Biol. 2017 Sep;24(9):717-725. doi: 10.1038/nsmb.3448. Epub 2017 Aug 7.
[Role of microtubule severing proteins in cytoskeleton reorganization].
Wacławek E, Włoga D.
Postepy Biochem. 2016;62(1):52-59. Review. Polish.
[Microtubule severing proteins - structure and activity regulation].
Postepy Biochem. 2016;62(1):46-51. Review. Polish.
Modeling the effects of lattice defects on microtubule breaking and healing.
Jiang N, Bailey ME, Burke J, Ross JL, Dima RI.
Cytoskeleton (Hoboken). 2017 Jan;74(1):3-17. doi: 10.1002/cm.21346.
Microtubules in health and degenerative disease of the nervous system.
Matamoros AJ, Baas PW.
Brain Res Bull. 2016 Sep;126(Pt 3):217-225. doi: 10.1016/j.brainresbull.2016.06.016. Epub 2016 Jun 27. Review.
Invited review: Microtubule severing enzymes couple atpase activity with tubulin GTPase spring loading.
Bailey ME, Jiang N, Dima RI, Ross JL.
Biopolymers. 2016 Aug;105(8):547-56. doi: 10.1002/bip.22842. Review.
Stability properties of neuronal microtubules.
Baas PW, Rao AN, Matamoros AJ, Leo L.
Cytoskeleton (Hoboken). 2016 Sep;73(9):442-60. doi: 10.1002/cm.21286. Review.
Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines.
Monroe N, Hill CP.
J Mol Biol. 2016 May 8;428(9 Pt B):1897-911. doi: 10.1016/j.jmb.2015.11.004. Epub 2015 Nov 10. Review.
Microtubule severing by katanin p60 AAA+ ATPase requires the C-terminal acidic tails of both α- and β-tubulins and basic amino acid residues in the AAA+ ring pore.
Johjima A, Noi K, Nishikori S, Ogi H, Esaki M, Ogura T.
J Biol Chem. 2015 May 1;290(18):11762-70. doi: 10.1074/jbc.M114.614768. Epub 2015 Mar 24.
Cold temperature improves mobility and survival in Drosophila models of autosomal-dominant hereditary spastic paraplegia (AD-HSP).
Baxter SL, Allard DE, Crowl C, Sherwood NT.
Dis Model Mech. 2014 Aug;7(8):1005-12. doi: 10.1242/dmm.013987. Epub 2014 Jun 6.
Microtubule-severing protein Katanin regulates neuromuscular junction development and dendritic elaboration in Drosophila.
Mao CX, Xiong Y, Xiong Z, Wang Q, Zhang YQ, Jin S.
Development. 2014 Mar;141(5):1064-74. doi: 10.1242/dev.097774.
Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons.
Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Plötz S, Boyer L, Marchetto MC, Aigner S, Sticht H, Groemer TW, Hehr U, Lampert A, Schlötzer-Schrehardt U, Winkler J, Gage FH, Winner B.
Hum Mol Genet. 2014 May 15;23(10):2527-41. doi: 10.1093/hmg/ddt644. Epub 2013 Dec 30.
Purification and biophysical analysis of microtubule-severing enzymes in vitro.
Diaz-Valencia JD, Bailey M, Ross JL.
Methods Cell Biol. 2013;115:191-213. doi: 10.1016/B978-0-12-407757-7.00013-X.
Katanin-p80 gene promoter characterization and regulation via Elk1.
Selçuk E, Kırımtay K, Canbaz D, Cesur GI, Korulu S, Karabay A.
PLoS One. 2013 Jul 24;8(7):e69423. doi: 10.1371/journal.pone.0069423. Print 2013.
An Arabidopsis ATPase gene involved in nematode-induced syncytium development and abiotic stress responses.
Ali MA, Plattner S, Radakovic Z, Wieczorek K, Elashry A, Grundler FM, Ammelburg M, Siddique S, Bohlmann H.
Plant J. 2013 Jun;74(5):852-66. doi: 10.1111/tpj.12170. Epub 2013 Apr 16.
MIT domain of Vps4 is a Ca2+-dependent phosphoinositide-binding domain.
Iwaya N, Takasu H, Goda N, Shirakawa M, Tanaka T, Hamada D, Hiroaki H.
J Biochem. 2013 May;153(5):473-81. doi: 10.1093/jb/mvt012. Epub 2013 Feb 19.
Spastin's microtubule-binding properties and comparison to katanin.
Eckert T, Le DT, Link S, Friedmann L, Woehlke G.
PLoS One. 2012;7(12):e50161. doi: 10.1371/journal.pone.0050161. Epub 2012 Dec 13.
Normal spastin gene dosage is specifically required for axon regeneration.
Stone MC, Rao K, Gheres KW, Kim S, Tao J, La Rochelle C, Folker CT, Sherwood NT, Rolls MM.
Cell Rep. 2012 Nov 29;2(5):1340-50. doi: 10.1016/j.celrep.2012.09.032. Epub 2012 Nov 1.
Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila.
Stewart A, Tsubouchi A, Rolls MM, Tracey WD, Sherwood NT.
J Neurosci. 2012 Aug 22;32(34):11631-42. doi: 10.1523/JNEUROSCI.0729-12.2012.
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