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Items: 1 to 20 of 41


Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in Vitro Splicing Inhibition.

Ghosh AK, Veitschegger AM, Nie S, Relitti N, MacRae AJ, Jurica MS.

J Org Chem. 2018 May 4;83(9):5187-5198. doi: 10.1021/acs.joc.8b00593. Epub 2018 Apr 26.


Prp8 positioning of U5 snRNA is linked to 5' splice site recognition.

MacRae AJ, Mayerle M, Hrabeta-Robinson E, Chalkley RJ, Guthrie C, Burlingame AL, Jurica MS.

RNA. 2018 Jun;24(6):769-777. doi: 10.1261/rna.065458.117. Epub 2018 Feb 27.


Enantioselective Synthesis of Spliceostatin G and Evaluation of Bioactivity of Spliceostatin G and Its Methyl Ester.

Ghosh AK, Reddy GC, MacRae AJ, Jurica MS.

Org Lett. 2018 Jan 5;20(1):96-99. doi: 10.1021/acs.orglett.7b03456. Epub 2017 Dec 8.


Modulating splicing with small molecular inhibitors of the spliceosome.

Effenberger KA, Urabe VK, Jurica MS.

Wiley Interdiscip Rev RNA. 2017 Mar;8(2). doi: 10.1002/wrna.1381. Epub 2016 Jul 21. Review.


Design, synthesis and in vitro splicing inhibition of desmethyl and carba-derivatives of herboxidiene.

Ghosh AK, Lv K, Ma N, Cárdenas EL, Effenberger KA, Jurica MS.

Org Biomol Chem. 2016 Jun 21;14(23):5263-71. doi: 10.1039/c6ob00725b. Epub 2016 May 18.


Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages.

Effenberger KA, Urabe VK, Prichard BE, Ghosh AK, Jurica MS.

RNA. 2016 Mar;22(3):350-9. doi: 10.1261/rna.053108.115. Epub 2016 Jan 7.


The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes.

Effenberger KA, James RC, Urabe VK, Dickey BJ, Linington RG, Jurica MS.

J Biol Chem. 2015 Nov 13;290(46):27524-31. doi: 10.1074/jbc.M115.673210. Epub 2015 Sep 25.


Nuclear cyclophilins affect spliceosome assembly and function in vitro.

Adams BM, Coates MN, Jackson SR, Jurica MS, Davis TL.

Biochem J. 2015 Jul 15;469(2):223-33. doi: 10.1042/BJ20150396. Epub 2015 May 13.


Enantioselective synthesis of spliceostatin E and evaluation of biological activity.

Ghosh AK, Veitschegger AM, Sheri VR, Effenberger KA, Prichard BE, Jurica MS.

Org Lett. 2014 Dec 5;16(23):6200-3. doi: 10.1021/ol503127r. Epub 2014 Nov 25.


Chromatin structure analysis of single gene molecules by psoralen cross-linking and electron microscopy.

Brown CR, Eskin JA, Hamperl S, Griesenbeck J, Jurica MS, Boeger H.

Methods Mol Biol. 2015;1228:93-121. doi: 10.1007/978-1-4939-1680-1_9.


Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives.

Ghosh AK, Chen ZH, Effenberger KA, Jurica MS.

J Org Chem. 2014 Jun 20;79(12):5697-709. doi: 10.1021/jo500800k. Epub 2014 May 30.


Total synthesis of GEX1Q1, assignment of C-5 stereoconfiguration and evaluation of spliceosome inhibitory activity.

Ghosh AK, Ma N, Effenberger KA, Jurica MS.

Org Lett. 2014 Jun 6;16(11):3154-7. doi: 10.1021/ol501345d. Epub 2014 May 28.


Isolation and accumulation of spliceosomal assembly intermediates.

Ilagan JO, Jurica MS.

Methods Mol Biol. 2014;1126:179-92. doi: 10.1007/978-1-62703-980-2_14.


Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs.

Effenberger KA, Anderson DD, Bray WM, Prichard BE, Ma N, Adams MS, Ghosh AK, Jurica MS.

J Biol Chem. 2014 Jan 24;289(4):1938-47. doi: 10.1074/jbc.M113.515536. Epub 2013 Dec 3.


Linking stochastic fluctuations in chromatin structure and gene expression.

Brown CR, Mao C, Falkovskaia E, Jurica MS, Boeger H.

PLoS Biol. 2013;11(8):e1001621. doi: 10.1371/journal.pbio.1001621. Epub 2013 Aug 6.


A high-throughput splicing assay identifies new classes of inhibitors of human and yeast spliceosomes.

Effenberger KA, Perriman RJ, Bray WM, Lokey RS, Ares M Jr, Jurica MS.

J Biomol Screen. 2013 Oct;18(9):1110-20. doi: 10.1177/1087057113493117. Epub 2013 Jun 14.


Rearrangements within human spliceosomes captured after exon ligation.

Ilagan JO, Chalkley RJ, Burlingame AL, Jurica MS.

RNA. 2013 Mar;19(3):400-12. doi: 10.1261/rna.034223.112. Epub 2013 Jan 23.


Coordination of copper to the membrane-bound form of ╬▒-synuclein.

Dudzik CG, Walter ED, Abrams BS, Jurica MS, Millhauser GL.

Biochemistry. 2013 Jan 8;52(1):53-60. doi: 10.1021/bi301475q. Epub 2012 Dec 26.


Spliceosome database: a tool for tracking components of the spliceosome.

Cvitkovic I, Jurica MS.

Nucleic Acids Res. 2013 Jan;41(Database issue):D132-41. doi: 10.1093/nar/gks999. Epub 2012 Oct 30.


Breaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediate.

Coltri P, Effenberger K, Chalkley RJ, Burlingame AL, Jurica MS.

PLoS One. 2011 Apr 19;6(4):e19061. doi: 10.1371/journal.pone.0019061.

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