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J Gen Intern Med. 2007 Dec;22(12):1695-703. Epub 2007 Oct 6.

Effectiveness of a lifestyle intervention on metabolic syndrome. A randomized controlled trial.

Author information

1
Department of Internal Medicine, University of Turin, Turin, Italy. sbo@molinette.piemonte.it

Abstract

BACKGROUND:

Intensive lifestyle intervention significantly reduces the progression to diabetes in high-risk individuals.

OBJECTIVE:

It is not known whether a program of moderate intervention might effectively reduce metabolic abnormalities in the general population.

DESIGN:

Two-arm randomized controlled 1-year trial.

PATIENTS:

Three hundred and thirty-five patients participated from a dysmetabolic population-based cohort of 375 adults aged 45-64 years in northwestern Italy.

MEASUREMENTS:

We compared the effectiveness of a general recommendation-based program of lifestyle intervention carried out by trained professionals versus standard unstructured information given by family physicians at reducing the prevalence of multiple metabolic and inflammatory abnormalities.

RESULTS:

At baseline, clinical/anthropometric/laboratory and lifestyle characteristics of the intervention (n = 169) and control (n = 166) groups were not significantly different. The former significantly reduced total/saturated fat intake and increased polyunsaturated fat/fiber intake and exercise level compared to the controls. Weight, waist circumference, high-sensitivity C-reactive protein, and most of the metabolic syndrome components decreased in the intervention group and increased in the controls after 12 months. Lifestyle intervention significantly reduced metabolic syndrome (odds ratio [OR] = 0.28; 95% CI 0.18-0.44), with a 31% (21-41) absolute risk reduction, corresponding to 3.2 (2-5) patients needing to be treated to prevent 1 case after 12 months. The intervention significantly reduced the prevalence of central obesity (OR = 0.33; 0.20-0.56), and hypertriglyceridemia (OR = 0.48; 0.31-0.75) and the incidence of diabetes (OR = 0.23; 0.06-0.85).

CONCLUSION:

A lifestyle intervention based on general recommendations was effective in reducing multiple metabolic/inflammatory abnormalities. The usual care by family physicians was ineffective at modifying progressive metabolic deterioration in high-risk individuals.

PMID:
17922167
PMCID:
PMC2219825
DOI:
10.1007/s11606-007-0399-6
[Indexed for MEDLINE]
Free PMC Article

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