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Items: 1 to 20 of 58

1.

Emerging Gene Therapies for Genetic Hearing Loss.

Ahmed H, Shubina-Oleinik O, Holt JR.

J Assoc Res Otolaryngol. 2017 Oct;18(5):649-670. doi: 10.1007/s10162-017-0634-8. Epub 2017 Aug 16. Review.

PMID:
28815315
2.

Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells.

Koehler KR, Nie J, Longworth-Mills E, Liu XP, Lee J, Holt JR, Hashino E.

Nat Biotechnol. 2017 Jun;35(6):583-589. doi: 10.1038/nbt.3840. Epub 2017 May 1.

3.

Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c.

Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS.

Nat Biotechnol. 2017 Mar;35(3):264-272. doi: 10.1038/nbt.3801. Epub 2017 Feb 6.

4.

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear.

Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LH.

Nat Biotechnol. 2017 Mar;35(3):280-284. doi: 10.1038/nbt.3781. Epub 2017 Feb 6.

5.

Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?

Corey DP, Holt JR.

J Neurosci. 2016 Oct 26;36(43):10921-10926.

6.

RNA Interference Prevents Autosomal-Dominant Hearing Loss.

Shibata SB, Ranum PT, Moteki H, Pan B, Goodwin AT, Goodman SS, Abbas PJ, Holt JR, Smith RJH.

Am J Hum Genet. 2016 Jun 2;98(6):1101-1113. doi: 10.1016/j.ajhg.2016.03.028. Epub 2016 May 26.

7.

Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells.

Liu XP, Koehler KR, Mikosz AM, Hashino E, Holt JR.

Nat Commun. 2016 May 24;7:11508. doi: 10.1038/ncomms11508.

8.

Recessive mutations of TMC1 associated with moderate to severe hearing loss.

Imtiaz A, Maqsood A, Rehman AU, Morell RJ, Holt JR, Friedman TB, Naz S.

Neurogenetics. 2016 Apr;17(2):115-123. doi: 10.1007/s10048-016-0477-1. Epub 2016 Feb 16.

9.

TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia.

Kurima K, Ebrahim S, Pan B, Sedlacek M, Sengupta P, Millis BA, Cui R, Nakanishi H, Fujikawa T, Kawashima Y, Choi BY, Monahan K, Holt JR, Griffith AJ, Kachar B.

Cell Rep. 2015 Sep 8;12(10):1606-17. doi: 10.1016/j.celrep.2015.07.058. Epub 2015 Aug 28.

10.

The molecules that mediate sensory transduction in the mammalian inner ear.

Pan B, Holt JR.

Curr Opin Neurobiol. 2015 Oct;34:165-71. doi: 10.1016/j.conb.2015.06.013. Epub 2015 Jul 25. Review.

11.

Tmc gene therapy restores auditory function in deaf mice.

Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR.

Sci Transl Med. 2015 Jul 8;7(295):295ra108. doi: 10.1126/scitranslmed.aab1996.

PMID:
26157030
12.

Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation.

Kawashima Y, Kurima K, Pan B, Griffith AJ, Holt JR.

Pflugers Arch. 2015 Jan;467(1):85-94. doi: 10.1007/s00424-014-1582-3. Epub 2014 Jul 31. Review.

13.

Sound strategies for hearing restoration.

Géléoc GS, Holt JR.

Science. 2014 May 9;344(6184):1241062. doi: 10.1126/science.1241062. Review.

14.

Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons.

Horwitz GC, Risner-Janiczek JR, Holt JR.

J Gen Physiol. 2014 Apr;143(4):481-97. doi: 10.1085/jgp.201311126. Epub 2014 Mar 17.

15.

TMC function in hair cell transduction.

Holt JR, Pan B, Koussa MA, Asai Y.

Hear Res. 2014 May;311:17-24. doi: 10.1016/j.heares.2014.01.001. Epub 2014 Jan 11. Review.

16.

Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice.

Zou J, Zheng T, Ren C, Askew C, Liu XP, Pan B, Holt JR, Wang Y, Yang J.

Hum Mol Genet. 2014 May 1;23(9):2374-90. doi: 10.1093/hmg/ddt629. Epub 2013 Dec 11.

17.

A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing.

Yu WM, Appler JM, Kim YH, Nishitani AM, Holt JR, Goodrich LV.

Elife. 2013 Dec 10;2:e01341. doi: 10.7554/eLife.01341.

18.

Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear.

Kim YH, Holt JR.

J Gen Physiol. 2013 Sep;142(3):207-23. doi: 10.1085/jgp.201311019.

19.

TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear.

Pan B, Géléoc GS, Asai Y, Horwitz GC, Kurima K, Ishikawa K, Kawashima Y, Griffith AJ, Holt JR.

Neuron. 2013 Aug 7;79(3):504-15. doi: 10.1016/j.neuron.2013.06.019. Epub 2013 Jul 18.

20.

Gene therapy for deaf mice goes viral.

Holt JR, Vandenberghe LH.

Mol Ther. 2012 Oct;20(10):1836-7. doi: 10.1038/mt.2012.196. No abstract available.

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