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Sensing Mitochondrial Acetyl-CoA to Tune Respiration.

Mills CA, Trub AG, Hirschey MD.

Trends Endocrinol Metab. 2018 Nov 12. pii: S1043-2760(18)30189-9. doi: 10.1016/j.tem.2018.10.003. [Epub ahead of print]


Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β Cell Metabolism in the Absence of Overnutrition.

Peterson BS, Campbell JE, Ilkayeva O, Grimsrud PA, Hirschey MD, Newgard CB.

Cell Rep. 2018 Jul 3;24(1):209-223.e6. doi: 10.1016/j.celrep.2018.05.088.


Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload.

Hershberger KA, Abraham DM, Liu J, Locasale JW, Grimsrud PA, Hirschey MD.

J Biol Chem. 2018 Jul 6;293(27):10630-10645. doi: 10.1074/jbc.RA118.002187. Epub 2018 May 16.


Reactive Acyl-CoA Species Modify Proteins and Induce Carbon Stress.

Trub AG, Hirschey MD.

Trends Biochem Sci. 2018 May;43(5):369-379. doi: 10.1016/j.tibs.2018.02.002. Epub 2018 Feb 22. Review.


Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways.

Hu Y, Semova I, Sun X, Kang H, Chahar S, Hollenberg AN, Masson D, Hirschey MD, Miao J, Biddinger SB.

J Biol Chem. 2018 Feb 9;293(6):2006-2014. doi: 10.1074/jbc.M117.782557. Epub 2017 Dec 8.


Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.

Weir HJ, Yao P, Huynh FK, Escoubas CC, Goncalves RL, Burkewitz K, Laboy R, Hirschey MD, Mair WB.

Cell Metab. 2017 Dec 5;26(6):884-896.e5. doi: 10.1016/j.cmet.2017.09.024. Epub 2017 Oct 26.


daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival.

Hibshman JD, Doan AE, Moore BT, Kaplan RE, Hung A, Webster AK, Bhatt DP, Chitrakar R, Hirschey MD, Baugh LR.

Elife. 2017 Oct 24;6. pii: e30057. doi: 10.7554/eLife.30057.


Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight.

Rajabi N, Auth M, Troelsen KR, Pannek M, Bhatt DP, Fontenas M, Hirschey MD, Steegborn C, Madsen AS, Olsen CA.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14836-14841. doi: 10.1002/anie.201709050. Epub 2017 Nov 2.


Sirtuin 5 is required for mouse survival in response to cardiac pressure overload.

Hershberger KA, Abraham DM, Martin AS, Mao L, Liu J, Gu H, Locasale JW, Hirschey MD.

J Biol Chem. 2017 Dec 1;292(48):19767-19781. doi: 10.1074/jbc.M117.809897. Epub 2017 Oct 2.


Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio.

Anderson KA, Madsen AS, Olsen CA, Hirschey MD.

Biochim Biophys Acta Bioenerg. 2017 Dec;1858(12):991-998. doi: 10.1016/j.bbabio.2017.09.005. Epub 2017 Sep 22. Review.


Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.

Assiri MA, Roy SR, Harris PS, Ali H, Liang Y, Shearn CT, Orlicky DJ, Roede JR, Hirschey MD, Backos DS, Fritz KS.

Alcohol Clin Exp Res. 2017 Oct;41(10):1705-1714. doi: 10.1111/acer.13473. Epub 2017 Sep 14.


Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.

Huynh FK, Hu X, Lin Z, Johnson JD, Hirschey MD.

J Inherit Metab Dis. 2018 Jan;41(1):59-72. doi: 10.1007/s10545-017-0069-8. Epub 2017 Jul 19.


Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model.

Martin AS, Abraham DM, Hershberger KA, Bhatt DP, Mao L, Cui H, Liu J, Liu X, Muehlbauer MJ, Grimsrud PA, Locasale JW, Payne RM, Hirschey MD.

JCI Insight. 2017 Jul 20;2(14). pii: 93885. doi: 10.1172/jci.insight.93885. [Epub ahead of print]


Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy.

Stram AR, Wagner GR, Fogler BD, Pride PM, Hirschey MD, Payne RM.

PLoS One. 2017 May 25;12(5):e0178354. doi: 10.1371/journal.pone.0178354. eCollection 2017.


SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.

Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, Olsen CA, Campbell JE, Muoio DM, Grimsrud PA, Hirschey MD.

Cell Metab. 2017 Apr 4;25(4):838-855.e15. doi: 10.1016/j.cmet.2017.03.003.


A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.

Wagner GR, Bhatt DP, O'Connell TM, Thompson JW, Dubois LG, Backos DS, Yang H, Mitchell GA, Ilkayeva OR, Stevens RD, Grimsrud PA, Hirschey MD.

Cell Metab. 2017 Apr 4;25(4):823-837.e8. doi: 10.1016/j.cmet.2017.03.006.


A Prob(e)able Route to Lysine Acylation.

Wagner GR, Hirschey MD.

Cell Chem Biol. 2017 Feb 16;24(2):126-128. doi: 10.1016/j.chembiol.2017.01.011.


Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases.

Hershberger KA, Martin AS, Hirschey MD.

Nat Rev Nephrol. 2017 Apr;13(4):213-225. doi: 10.1038/nrneph.2017.5. Epub 2017 Feb 6. Review.


Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.

McDonnell E, Crown SB, Fox DB, Kitir B, Ilkayeva OR, Olsen CA, Grimsrud PA, Hirschey MD.

Cell Rep. 2016 Nov 1;17(6):1463-1472. doi: 10.1016/j.celrep.2016.10.012.


Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-Like Effect in Caenorhabditis elegans.

Luz AT, Godebo TR, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, Meyer JN.

Toxicol Sci. 2016 Nov;154(1):195. No abstract available.


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