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Items: 1 to 20 of 41


Function-Oriented Studies Targeting Pectenotoxin 2: Synthesis of the GH-Ring System and a Structurally Simplified Macrolactone.

O'Rourke NF, A M, Higgs HN, Eastman A, Micalizio GC.

Org Lett. 2017 Oct 6;19(19):5154-5157. doi: 10.1021/acs.orglett.7b02435. Epub 2017 Sep 13.


Calcium-mediated actin reset (CaAR) mediates acute cell adaptations.

Wales P, Schuberth CE, Aufschnaiter R, Fels J, García-Aguilar I, Janning A, Dlugos CP, Schäfer-Herte M, Klingner C, Wälte M, Kuhlmann J, Menis E, Hockaday Kang L, Maier KC, Hou W, Russo A, Higgs HN, Pavenstädt H, Vogl T, Roth J, Qualmann B, Kessels MM, Martin DE, Mulder B, Wedlich-Söldner R.

Elife. 2016 Dec 6;5. pii: e19850. doi: 10.7554/eLife.19850.


Actin filaments as dynamic reservoirs for Drp1 recruitment.

Hatch AL, Ji WK, Merrill RA, Strack S, Higgs HN.

Mol Biol Cell. 2016 Oct 15;27(20):3109-3121. Epub 2016 Aug 24.


Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury.

Subramanian B, Sun H, Yan P, Charoonratana VT, Higgs HN, Wang F, Lai KV, Valenzuela DM, Brown EJ, Schlöndorff JS, Pollak MR.

Kidney Int. 2016 Aug;90(2):363-372. doi: 10.1016/j.kint.2016.04.020. Epub 2016 Jun 24.


Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites.

Ji WK, Hatch AL, Merrill RA, Strack S, Higgs HN.

Elife. 2015 Nov 26;4:e11553. doi: 10.7554/eLife.11553.


Cell type-dependent mechanisms for formin-mediated assembly of filopodia.

Young LE, Heimsath EG, Higgs HN.

Mol Biol Cell. 2015 Dec 15;26(25):4646-59. doi: 10.1091/mbc.E15-09-0626. Epub 2015 Oct 7.


Assembly and turnover of short actin filaments by the formin INF2 and profilin.

Gurel PS, A M, Guo B, Shu R, Mierke DF, Higgs HN.

J Biol Chem. 2015 Sep 11;290(37):22494-506. doi: 10.1074/jbc.M115.670166. Epub 2015 Jun 29.


The formin FMNL3 assembles plasma membrane protrusions that participate in cell-cell adhesion.

Gauvin TJ, Young LE, Higgs HN.

Mol Biol Cell. 2015 Feb 1;26(3):467-77. doi: 10.1091/mbc.E14-07-1247. Epub 2014 Nov 26.


Novel roles for actin in mitochondrial fission.

Hatch AL, Gurel PS, Higgs HN.

J Cell Sci. 2014 Nov 1;127(Pt 21):4549-60. doi: 10.1242/jcs.153791. Epub 2014 Sep 12.


Monitoring ATP hydrolysis and ATPase inhibitor screening using (1)H NMR.

Guo B, Gurel PS, Shu R, Higgs HN, Pellegrini M, Mierke DF.

Chem Commun (Camb). 2014 Oct 18;50(81):12037-9. doi: 10.1039/c4cc04399e.


Connecting the cytoskeleton to the endoplasmic reticulum and Golgi.

Gurel PS, Hatch AL, Higgs HN.

Curr Biol. 2014 Jul 21;24(14):R660-R672. doi: 10.1016/j.cub.2014.05.033. Review.


Nanostructured self-assembly of inverted formin 2 (INF2) and F-actin-INF2 complexes revealed by atomic force microscopy.

Sharma S, Grintsevich EE, Woo J, Gurel PS, Higgs HN, Reisler E, Gimzewski JK.

Langmuir. 2014 Jul 1;30(25):7533-9. doi: 10.1021/la501748x. Epub 2014 Jun 20.


A role for myosin II in mammalian mitochondrial fission.

Korobova F, Gauvin TJ, Higgs HN.

Curr Biol. 2014 Feb 17;24(4):409-14. doi: 10.1016/j.cub.2013.12.032. Epub 2014 Jan 30.


Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse.

Kim J, Shapiro MJ, Bamidele AO, Gurel P, Thapa P, Higgs HN, Hedin KE, Shapiro VS, Billadeau DD.

PLoS One. 2014 Jan 13;9(1):e85090. doi: 10.1371/journal.pone.0085090. eCollection 2014.


INF2-mediated severing through actin filament encirclement and disruption.

Gurel PS, Ge P, Grintsevich EE, Shu R, Blanchoin L, Zhou ZH, Reisler E, Higgs HN.

Curr Biol. 2014 Jan 20;24(2):156-64. doi: 10.1016/j.cub.2013.12.018. Epub 2014 Jan 9.


Actin monomers activate inverted formin 2 by competing with its autoinhibitory interaction.

Ramabhadran V, Hatch AL, Higgs HN.

J Biol Chem. 2013 Sep 13;288(37):26847-55. doi: 10.1074/jbc.M113.472415. Epub 2013 Aug 6.


Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling.

Sun H, Schlondorff J, Higgs HN, Pollak MR.

J Am Soc Nephrol. 2013 May;24(6):917-29. doi: 10.1681/ASN.2012080834. Epub 2013 Apr 25.


An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2.

Korobova F, Ramabhadran V, Higgs HN.

Science. 2013 Jan 25;339(6118):464-7. doi: 10.1126/science.1228360.


FMNL3 FH2-actin structure gives insight into formin-mediated actin nucleation and elongation.

Thompson ME, Heimsath EG, Gauvin TJ, Higgs HN, Kull FJ.

Nat Struct Mol Biol. 2013 Jan;20(1):111-8. doi: 10.1038/nsmb.2462. Epub 2012 Dec 9.


Mutations to the formin homology 2 domain of INF2 protein have unexpected effects on actin polymerization and severing.

Ramabhadran V, Gurel PS, Higgs HN.

J Biol Chem. 2012 Oct 5;287(41):34234-45. doi: 10.1074/jbc.M112.365122. Epub 2012 Aug 9.

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