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Items: 1 to 20 of 68


Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection.

Malyshkina A, Littwitz-Salomon E, Sutter K, Zelinskyy G, Windmann S, Schimmer S, Paschen A, Streeck H, Hasenkrug KJ, Dittmer U.

Sci Rep. 2017 Aug 10;7(1):7785. doi: 10.1038/s41598-017-08578-7.


B Cell Requirement for Robust Regulatory T Cell Responses to Friend Retrovirus Infection.

Moore TC, Gonzaga LM, Mather JM, Messer RJ, Hasenkrug KJ.

MBio. 2017 Aug 1;8(4). pii: e01122-17. doi: 10.1128/mBio.01122-17.


Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction.

Barrett BS, Harper MS, Jones ST, Guo K, Heilman KJ, Kedl RM, Hasenkrug KJ, Santiago ML.

Retrovirology. 2017 Apr 17;14(1):25. doi: 10.1186/s12977-017-0349-2.


Ebola Virus Replication and Disease Without Immunopathology in Mice Expressing Transgenes to Support Human Myeloid and Lymphoid Cell Engraftment.

Spengler JR, Lavender KJ, Martellaro C, Carmody A, Kurth A, Keck JG, Saturday G, Scott DP, Nichol ST, Hasenkrug KJ, Spiropoulou CF, Feldmann H, Prescott J.

J Infect Dis. 2016 Oct 15;214(suppl 3):S308-S318. Epub 2016 Sep 6.


Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo.

Lavender KJ, Gibbert K, Peterson KE, Van Dis E, Francois S, Woods T, Messer RJ, Gawanbacht A, Müller JA, Münch J, Phillips K, Race B, Harper MS, Guo K, Lee EJ, Trilling M, Hengel H, Piehler J, Verheyen J, Wilson CC, Santiago ML, Hasenkrug KJ, Dittmer U.

J Virol. 2016 Jun 10;90(13):6001-13. doi: 10.1128/JVI.00451-16. Print 2016 Jul 1.


Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.

Li SX, Barrett BS, Guo K, Kassiotis G, Hasenkrug KJ, Dittmer U, Gibbert K, Santiago ML.

Sci Rep. 2016 Feb 5;6:20425. doi: 10.1038/srep20425.


Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2.

Halford WP, Geltz J, Messer RJ, Hasenkrug KJ.

PLoS One. 2015 Dec 15;10(12):e0145228. doi: 10.1371/journal.pone.0145228. eCollection 2015.


Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.

Akkina R, Allam A, Balazs AB, Blankson JN, Burnett JC, Casares S, Garcia JV, Hasenkrug KJ, Kashanchi F, Kitchen SG, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders-Beer BE, Shultz LD, Zack JA.

AIDS Res Hum Retroviruses. 2016 Feb;32(2):109-19. doi: 10.1089/AID.2015.0258.


No SEVI-mediated enhancement of rectal HIV-1 transmission of HIV-1 in two humanized mouse cohorts.

Van Dis ES, Moore TC, Lavender KJ, Messer RJ, Keppler OT, Verheyen J, Dittmer U, Hasenkrug KJ.

Virology. 2016 Jan 15;488:88-95. doi: 10.1016/j.virol.2015.11.005. Epub 2015 Nov 21.


Interferon-α Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency and Effector Mechanisms.

Harper MS, Guo K, Gibbert K, Lee EJ, Dillon SM, Barrett BS, McCarter MD, Hasenkrug KJ, Dittmer U, Wilson CC, Santiago ML.

PLoS Pathog. 2015 Nov 3;11(11):e1005254. doi: 10.1371/journal.ppat.1005254. eCollection 2015.


Stimulation of Toll-Like Receptors profoundly influences the titer of polyreactive antibodies in the circulation.

Gunti S, Messer RJ, Xu C, Yan M, Coleman WG Jr, Peterson KE, Hasenkrug KJ, Notkins AL.

Sci Rep. 2015 Oct 14;5:15066. doi: 10.1038/srep15066.


Serial infection of diverse host (Mus) genotypes rapidly impedes pathogen fitness and virulence.

Kubinak JL, Cornwall DH, Hasenkrug KJ, Adler FR, Potts WK.

Proc Biol Sci. 2015 Jan 7;282(1798):20141568. doi: 10.1098/rspb.2014.1568.


Activated CD8+ T cells induce expansion of Vβ5+ regulatory T cells via TNFR2 signaling.

Joedicke JJ, Myers L, Carmody AB, Messer RJ, Wajant H, Lang KS, Lang PA, Mak TW, Hasenkrug KJ, Dittmer U.

J Immunol. 2014 Sep 15;193(6):2952-60. doi: 10.4049/jimmunol.1400649. Epub 2014 Aug 6.


Clonotypic composition of the CD4+ T cell response to a vectored retroviral antigen is determined by its speed.

Thorborn G, Ploquin MJ, Eksmond U, Pike R, Bayer W, Dittmer U, Hasenkrug KJ, Pepper M, Kassiotis G.

J Immunol. 2014 Aug 15;193(4):1567-77. doi: 10.4049/jimmunol.1400667. Epub 2014 Jul 7.


Mice of the resistant H-2(b) haplotype mount broad CD4(+) T cell responses against 9 distinct Friend virus epitopes.

Messer RJ, Lavender KJ, Hasenkrug KJ.

Virology. 2014 May;456-457:139-44. doi: 10.1016/j.virol.2014.03.012. Epub 2014 Apr 5.


Tetherin promotes the innate and adaptive cell-mediated immune response against retrovirus infection in vivo.

Li SX, Barrett BS, Heilman KJ, Messer RJ, Liberatore RA, Bieniasz PD, Kassiotis G, Hasenkrug KJ, Santiago ML.

J Immunol. 2014 Jul 1;193(1):306-16. doi: 10.4049/jimmunol.1400490. Epub 2014 May 28.


Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection.

Halemano K, Guo K, Heilman KJ, Barrett BS, Smith DS, Hasenkrug KJ, Santiago ML.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7759-64. doi: 10.1073/pnas.1403361111. Epub 2014 May 12.


Production of bone marrow, liver, thymus (BLT) humanized mice on the C57BL/6 Rag2(-/-)γc(-/-)CD47(-/-) background.

Lavender KJ, Messer RJ, Race B, Hasenkrug KJ.

J Immunol Methods. 2014 May;407:127-34. doi: 10.1016/j.jim.2014.04.008. Epub 2014 Apr 24.


CD8+ T cells are essential for controlling acute friend retrovirus infection in C57BL/6 mice.

Joedicke JJ, Zelinskyy G, Dittmer U, Hasenkrug KJ.

J Virol. 2014 May;88(9):5200-1. doi: 10.1128/JVI.00312-14. No abstract available.


BLT-humanized C57BL/6 Rag2-/-γc-/-CD47-/- mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection.

Lavender KJ, Pang WW, Messer RJ, Duley AK, Race B, Phillips K, Scott D, Peterson KE, Chan CK, Dittmer U, Dudek T, Allen TM, Weissman IL, Hasenkrug KJ.

Blood. 2013 Dec 12;122(25):4013-20. doi: 10.1182/blood-2013-06-506949. Epub 2013 Sep 10. Erratum in: Blood. 2014 Sep 11;124(11):1848.

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