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Items: 12

1.

Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations.

Cloudsdale IS, Dickson JK Jr, Barta TE, Grella BS, Smith ED, Kulp JL 3rd, Guarnieri F, Kulp JL Jr.

Bioorg Med Chem. 2017 Aug 1;25(15):3947-3963. doi: 10.1016/j.bmc.2017.05.032. Epub 2017 May 19.

PMID:
28601508
2.

Design, synthesis, and pharmacological evaluation of glutamate carboxypeptidase II (GCPII) inhibitors based on thioalkylbenzoic acid scaffolds.

Stoermer D, Vitharana D, Hin N, Delahanty G, Duvall B, Ferraris DV, Grella BS, Hoover R, Rojas C, Shanholtz MK, Smith KP, Stathis M, Wu Y, Wozniak KM, Slusher BS, Tsukamoto T.

J Med Chem. 2012 Jun 28;55(12):5922-32. doi: 10.1021/jm300488m. Epub 2012 Jun 12.

PMID:
22642259
3.

The discovery and structure-activity relationships of indole-based inhibitors of glutamate carboxypeptidase II.

Grella B, Adams J, Berry JF, Delahanty G, Ferraris DV, Majer P, Ni C, Shukla K, Shuler SA, Slusher BS, Stathis M, Tsukamoto T.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7222-5. doi: 10.1016/j.bmcl.2010.10.109. Epub 2010 Oct 26.

PMID:
21074428
4.

Optimization of the indenone ring of indenoisoquinoline topoisomerase I inhibitors.

Morrell A, Placzek M, Parmley S, Grella B, Antony S, Pommier Y, Cushman M.

J Med Chem. 2007 Sep 6;50(18):4388-404. Epub 2007 Aug 4.

PMID:
17676830
5.

Investigation of the affinities of two new beta-carbolines for rat brain imidazoline(2) receptors.

Tyacke RJ, Lau A, Grella B, Glennon RA, Nutt DJ, Hudson AL.

Ann N Y Acad Sci. 2003 Dec;1009:361-3.

PMID:
15028612
6.

Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.

Glennon RA, Grella B, Tyacke RJ, Lau A, Westaway J, Hudson AL.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):999-1002.

PMID:
15013009
7.

Binding of an imidazopyridoindole at imidazoline I2 receptors.

Glennon RA, Grella B, Tyacke RJ, Lau A, Westaway J, Hudson AL.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):527-9.

PMID:
14698196
8.

Binding of beta-carbolines at 5-HT(2) serotonin receptors.

Grella B, Teitler M, Smith C, Herrick-Davis K, Glennon RA.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4421-5.

PMID:
14643338
9.

Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.

Khorana N, Smith C, Herrick-Davis K, Purohit A, Teitler M, Grella B, Dukat M, Glennon RA.

J Med Chem. 2003 Aug 28;46(18):3930-7.

PMID:
12930153
10.

Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.

Majer P, Jackson PF, Delahanty G, Grella BS, Ko YS, Li W, Liu Q, Maclin KM, Poláková J, Shaffer KA, Stoermer D, Vitharana D, Wang EY, Zakrzewski A, Rojas C, Slusher BS, Wozniak KM, Burak E, Limsakun T, Tsukamoto T.

J Med Chem. 2003 May 8;46(10):1989-96.

PMID:
12723961
11.

Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors.

Glennon RA, Dukat M, Grella B, Hong S, Costantino L, Teitler M, Smith C, Egan C, Davis K, Mattson MV.

Drug Alcohol Depend. 2000 Aug 1;60(2):121-32.

PMID:
10940539
12.

Investigation of hallucinogenic and related beta-carbolines.

Grella B, Dukat M, Young R, Teitler M, Herrick-Davis K, Gauthier CB, Glennon RA.

Drug Alcohol Depend. 1998 Apr 1;50(2):99-107.

PMID:
9649961

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