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Clinical Relevance of Galectin-1 and Galectin-3 in Rheumatoid Arthritis Patients: Differential Regulation and Correlation With Disease Activity.

Mendez-Huergo SP, Hockl PF, Stupirski JC, Maller SM, Morosi LG, Pinto NA, Berón AM, Musuruana JL, Nasswetter GG, Cavallasca JA, Rabinovich GA.

Front Immunol. 2019 Jan 9;9:3057. doi: 10.3389/fimmu.2018.03057. eCollection 2018.


Association of galectin-3 with markers of myocardial function, atherosclerosis, and vascular fibrosis in patients with rheumatoid arthritis.

Anyfanti P, Gkaliagkousi E, Gavriilaki E, Triantafyllou A, Dolgyras P, Galanopoulou V, Aslanidis S, Douma S.

Clin Cardiol. 2019 Jan;42(1):62-68. doi: 10.1002/clc.23105. Epub 2018 Nov 27.


Galectin-8 induces functional disease markers in human osteoarthritis and cooperates with galectins-1 and -3.

Weinmann D, Kenn M, Schmidt S, Schmidt K, Walzer SM, Kubista B, Windhager R, Schreiner W, Toegel S, Gabius HJ.

Cell Mol Life Sci. 2018 Jun 22. doi: 10.1007/s00018-018-2856-2. [Epub ahead of print]


Galectin-1 and galectin-3 expression in equine mesenchymal stromal cells (MSCs), synovial fibroblasts and chondrocytes, and the effect of inflammation on MSC motility.

Reesink HL, Sutton RM, Shurer CR, Peterson RP, Tan JS, Su J, Paszek MJ, Nixon AJ.

Stem Cell Res Ther. 2017 Nov 2;8(1):243. doi: 10.1186/s13287-017-0691-2.


Galectin-3 is Persistently Increased in Early Rheumatoid Arthritis (RA) and Associates with Anti-CCP Seropositivity and MRI Bone Lesions, While Early Fibrosis Markers Correlate with Disease Activity.

Issa SF, Christensen AF, Lindegaard HM, Hetland ML, Hørslev-Petersen K, Stengaard-Pedersen K, Ejbjerg BJ, Lottenburger T, Ellingsen T, Pedersen JK, Junker K, Svendsen A, Tarp U, Østergaard M, Junker P.

Scand J Immunol. 2017 Dec;86(6):471-478. doi: 10.1111/sji.12619. Epub 2017 Nov 1.


Increased galectin-3 may serve as a serologic signature of pre-rheumatoid arthritis while markers of synovitis and cartilage do not differ between early undifferentiated arthritis subsets.

Issa SF, Duer A, Østergaard M, Hørslev-Petersen K, Hetland ML, Hansen MS, Junker K, Lindegaard HM, Møller JM, Junker P.

Arthritis Res Ther. 2017 Apr 26;19(1):80. doi: 10.1186/s13075-017-1282-4.


Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation.

Gittens BR, Bodkin JV, Nourshargh S, Perretti M, Cooper D.

J Immunol. 2017 Jun 1;198(11):4458-4469. doi: 10.4049/jimmunol.1600709. Epub 2017 Apr 24.


Alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in DBA/1 mice.

Sime K, Choy EH, Williams AS.

Adipocyte. 2017 Apr 3;6(2):87-101. doi: 10.1080/21623945.2017.1295174. Epub 2017 Feb 21.


Galectin-3-null mice display defective neutrophil clearance during acute inflammation.

Wright RD, Souza PR, Flak MB, Thedchanamoorthy P, Norling LV, Cooper D.

J Leukoc Biol. 2017 Mar;101(3):717-726. doi: 10.1189/jlb.3A0116-026RR. Epub 2016 Oct 12.


Galectin-3: A key player in arthritis.

Hu Y, Yéléhé-Okouma M, Ea HK, Jouzeau JY, Reboul P.

Joint Bone Spine. 2017 Jan;84(1):15-20. doi: 10.1016/j.jbspin.2016.02.029. Epub 2016 May 26. Review.


A proteomic profile of synoviocyte lesions microdissected from formalin-fixed paraffin-embedded synovial tissues of rheumatoid arthritis.

Hayashi J, Kihara M, Kato H, Nishimura T.

Clin Proteomics. 2015 Aug 6;12(1):20. doi: 10.1186/s12014-015-9091-8. eCollection 2015.


Within-day variation and influence of physical exercise on circulating Galectin-3 in patients with rheumatoid arthritis and healthy individuals.

Issa SF, Christensen AF, Lottenburger T, Junker K, Lindegaard H, Hørslev-Petersen K, Junker P.

Scand J Immunol. 2015 Jul;82(1):70-5. doi: 10.1111/sji.12301.


Galectin-3 is a sensor-regulator of toll-like receptor pathways in synovial fibroblasts.

Arad U, Madar-Balakirski N, Angel-Korman A, Amir S, Tzadok S, Segal O, Menachem A, Gold A, Elkayam O, Caspi D.

Cytokine. 2015 May;73(1):30-5. doi: 10.1016/j.cyto.2015.01.016. Epub 2015 Feb 14.


The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection.

Curciarello R, Steele A, Cooper D, MacDonald TT, Kruidenier L, Kudo T.

PLoS One. 2014 Sep 22;9(9):e107933. doi: 10.1371/journal.pone.0107933. eCollection 2014.


Galectin-3: its role in asthma and potential as an anti-inflammatory target.

Gao P, Simpson JL, Zhang J, Gibson PG.

Respir Res. 2013 Dec 9;14:136. doi: 10.1186/1465-9921-14-136. Review.


Increased intracellular oxygen radical production in neutrophils during febrile episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome.

Sundqvist M, Wekell P, Osla V, Bylund J, Christenson K, Sävman K, Foell D, Cabral DA, Fasth A, Berg S, Brown KL, Karlsson A.

Arthritis Rheum. 2013 Nov;65(11):2971-83. doi: 10.1002/art.38134.


Circulating galectin-3 in infections and non-infectious inflammatory diseases.

ten Oever J, Giamarellos-Bourboulis EJ, van de Veerdonk FL, Stelma FF, Simon A, Janssen M, Johnson M, Pachot A, Kullberg BJ, Joosten LA, Netea MG.

Eur J Clin Microbiol Infect Dis. 2013 Dec;32(12):1605-10. doi: 10.1007/s10096-013-1919-4. Epub 2013 Jul 5.


Elevated production of galectin-3 is correlated with juvenile idiopathic arthritis disease activity, severity, and progression.

Ezzat MH, El-Gammasy TM, Shaheen KY, Osman AO.

Int J Rheum Dis. 2011 Oct;14(4):345-52. doi: 10.1111/j.1756-185X.2011.01632.x. Epub 2011 Jul 29.


Novel protagonists in autoinflammatory arthritis of familial Mediterranean fever.

Al-Salam S, Conca W.

Pediatrics. 2011 Aug;128(2):e464-70. doi: 10.1542/peds.2010-2998. Epub 2011 Jul 4.


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