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Inhibitory effects of fucoidan on NMDA receptors and l-type Ca2+ channels regulating the Ca2+ responses in rat neurons.

Wu H, Gao S, Terakawa S.

Pharm Biol. 2019 Dec;57(1):1-7. doi: 10.1080/13880209.2018.1548626.


Antioxidant Properties of Fucoidan Alleviate Acceleration and Exacerbation of Hippocampal Neuronal Death Following Transient Global Cerebral Ischemia in High-Fat Diet-Induced Obese Gerbils.

Ahn JH, Shin MC, Kim DW, Kim H, Song M, Lee TK, Lee JC, Kim H, Cho JH, Kim YM, Kim JD, Choi SY, Won MH, Park JH.

Int J Mol Sci. 2019 Jan 28;20(3). pii: E554. doi: 10.3390/ijms20030554.


Pretreated fucoidan confers neuroprotection against transient global cerebral ischemic injury in the gerbil hippocampal CA1 area via reducing of glial cell activation and oxidative stress.

Kim H, Ahn JH, Song M, Kim DW, Lee TK, Lee JC, Kim YM, Kim JD, Cho JH, Hwang IK, Yan BC, Won MH, Park JH.

Biomed Pharmacother. 2019 Jan;109:1718-1727. doi: 10.1016/j.biopha.2018.11.015. Epub 2018 Nov 20.


Fucoidan inhibits Ca2+ responses induced by a wide spectrum of agonists for G‑protein‑coupled receptors.

Wu H, Gao S, Fu M, Sakurai T, Terakawa S.

Mol Med Rep. 2018 Jan;17(1):1428-1436. doi: 10.3892/mmr.2017.8035. Epub 2017 Nov 13.


Protective Effect of Fucoidan Extract from Ecklonia cava on Hydrogen Peroxide-Induced Neurotoxicity.

Park SK, Kang JY, Kim JM, Park SH, Kwon BS, Kim GH, Heo HJ.

J Microbiol Biotechnol. 2018 Jan 28;28(1):40-49. doi: 10.4014/jmb.1710.10043.


Antinociceptive effects of fucoidan in rat models of vincristine-induced neuropathic pain.

Hu C, Zhao YT, Zhang G, Xu MF.

Mol Med Rep. 2017 Feb;15(2):975-980. doi: 10.3892/mmr.2016.6071. Epub 2016 Dec 23.


Anti-inflammatory effects of sodium alginate/gelatine porous scaffolds merged with fucoidan in murine microglial BV2 cells.

Nguyen VT, Ko SC, Oh GW, Heo SY, Jeon YJ, Park WS, Choi IW, Choi SW, Jung WK.

Int J Biol Macromol. 2016 Dec;93(Pt B):1620-1632. doi: 10.1016/j.ijbiomac.2016.05.078. Epub 2016 May 24.


Fucoidan Extracted from Hijiki Protects Brain Microvessel Endothelial Cells Against Diesel Exhaust Particle Exposure-Induced Disruption.

Choi YS, Eom SY, Kim IS, Ali SF, Kleinman MT, Kim YD, Kim H.

J Med Food. 2016 May;19(5):466-71. doi: 10.1089/jmf.2015.3635.


Structure-activity relationship of sulfated hetero/galactofucan polysaccharides on dopaminergic neuron.

Wang J, Liu H, Jin W, Zhang H, Zhang Q.

Int J Biol Macromol. 2016 Jan;82:878-83. doi: 10.1016/j.ijbiomac.2015.10.042. Epub 2015 Oct 18.


Fucoidan from Fucus vesiculosus Fails to Improve Outcomes Following Intracerebral Hemorrhage in Mice.

Burchell SR, Iniaghe LO, Zhang JH, Tang J.

Acta Neurochir Suppl. 2016;121:191-8. doi: 10.1007/978-3-319-18497-5_34.


Therapeutic effects of fucoidan in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: Role of NADPH oxidase-1.

Zhang FL, He Y, Zheng Y, Zhang WJ, Wang Q, Jia YJ, Song HL, An HT, Zhang HB, Qian YJ, Tong YL, Dong L, Wang XM.

CNS Neurosci Ther. 2014 Dec;20(12):1036-44. doi: 10.1111/cns.12340. Epub 2014 Nov 15.


Fucoidan attenuates the existing allodynia and hyperalgesia in a rat model of neuropathic pain.

Hu C, Zhang G, Zhao YT.

Neurosci Lett. 2014 Jun 13;571:66-71. doi: 10.1016/j.neulet.2014.04.030. Epub 2014 May 2.


Effect of basic fibroblast growth factor released from chitosan-fucoidan nanoparticles on neurite extension.

Huang YC, Yang YT.

J Tissue Eng Regen Med. 2016 May;10(5):418-27. doi: 10.1002/term.1752. Epub 2013 May 20.


The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function.

Levesque S, Taetzsch T, Lull ME, Johnson JA, McGraw C, Block ML.

J Neurochem. 2013 Jun;125(5):756-65. doi: 10.1111/jnc.12231. Epub 2013 Apr 2.


Controlled activity of mouse astrocytes on electrospun PCL nanofiber containing polysaccharides from brown seaweed.

Jung SM, Kim SH, Min SK, Shin HS.

In Vitro Cell Dev Biol Anim. 2012 Dec;48(10):633-40. doi: 10.1007/s11626-012-9566-0. Epub 2012 Nov 13.


Fucoidan prevents depression-like behavior in rats exposed to repeated restraint stress.

Lee B, Shim I, Lee H, Hahm DH.

J Nat Med. 2013 Jul;67(3):534-44. doi: 10.1007/s11418-012-0712-5. Epub 2012 Oct 23.


Fucoidan protects against lipopolysaccharide-induced rat neuronal damage and inhibits the production of proinflammatory mediators in primary microglia.

Cui YQ, Jia YJ, Zhang T, Zhang QB, Wang XM.

CNS Neurosci Ther. 2012 Oct;18(10):827-33. doi: 10.1111/j.1755-5949.2012.00372.x.


5-HT induces temporomandibular joint nociception in rats through the local release of inflammatory mediators and activation of local β adrenoceptors.

Oliveira-Fusaro MC, Clemente-Napimoga JT, Teixeira JM, Torres-Chávez KE, Parada CA, Tambeli CH.

Pharmacol Biochem Behav. 2012 Sep;102(3):458-64. doi: 10.1016/j.pbb.2012.06.005. Epub 2012 Jun 7.


Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia.

Fu H, Liu B, Frost JL, Hong S, Jin M, Ostaszewski B, Shankar GM, Costantino IM, Carroll MC, Mayadas TN, Lemere CA.

Glia. 2012 May;60(6):993-1003. doi: 10.1002/glia.22331. Epub 2012 Mar 21.

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