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Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation.

Dela Paz NG, Frangos JA.

Biochem Biophys Res Commun. 2018 Feb 26;497(1):220-225. doi: 10.1016/j.bbrc.2018.02.058. Epub 2018 Feb 8.


Shear stress induces Gαq/11 activation independently of G protein-coupled receptor activation in endothelial cells.

Dela Paz NG, Melchior B, Frangos JA.

Am J Physiol Cell Physiol. 2017 Apr 1;312(4):C428-C437. doi: 10.1152/ajpcell.00148.2016. Epub 2017 Feb 1.


Fluid shear stress induces upregulation of COX-2 and PGI2 release in endothelial cells via a pathway involving PECAM-1, PI3K, FAK, and p38.

Russell-Puleri S, Dela Paz NG, Adams D, Chattopadhyay M, Cancel L, Ebong E, Orr AW, Frangos JA, Tarbell JM.

Am J Physiol Heart Circ Physiol. 2017 Mar 1;312(3):H485-H500. doi: 10.1152/ajpheart.00035.2016. Epub 2016 Dec 23.


NO-Donor Dihydroartemisinin Derivatives as Multitarget Agents for the Treatment of Cerebral Malaria.

Bertinaria M, Orjuela-Sanchez P, Marini E, Guglielmo S, Hofer A, Martins YC, Zanini GM, Frangos JA, Gasco A, Fruttero R, Carvalho LJ.

J Med Chem. 2015 Oct 8;58(19):7895-9. doi: 10.1021/acs.jmedchem.5b01036. Epub 2015 Sep 24.


Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor.

Kalyanaraman H, Schwappacher R, Joshua J, Zhuang S, Scott BT, Klos M, Casteel DE, Frangos JA, Dillmann W, Boss GR, Pilz RB.

Sci Signal. 2014 May 20;7(326):ra48. doi: 10.1126/scisignal.2004911.


Heparan sulfates mediate the interaction between platelet endothelial cell adhesion molecule-1 (PECAM-1) and the Gαq/11 subunits of heterotrimeric G proteins.

dela Paz NG, Melchior B, Shayo FY, Frangos JA.

J Biol Chem. 2014 Mar 14;289(11):7413-24. doi: 10.1074/jbc.M113.542514. Epub 2014 Feb 4.


Rescue of a primary myelofibrosis model by retinoid-antagonist therapy.

Hong SH, Dvorak-Ewell M, Stevens HY, Barish GD, Castro GL, Nofsinger R, Frangos JA, Shoback D, Evans RM.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18820-5. doi: 10.1073/pnas.1318974110. Epub 2013 Nov 4.


Cerebral tissue oxygenation impairment during experimental cerebral malaria.

Cabrales P, Martins YC, Ong PK, Zanini GM, Frangos JA, Carvalho LJ.

Virulence. 2013 Nov 15;4(8):686-97. doi: 10.4161/viru.26348. Epub 2013 Sep 11.


Transdermal glyceryl trinitrate as an effective adjunctive treatment with artemether for late-stage experimental cerebral malaria.

Orjuela-Sánchez P, Ong PK, Zanini GM, Melchior B, Martins YC, Meays D, Frangos JA, Carvalho LJ.

Antimicrob Agents Chemother. 2013 Nov;57(11):5462-71. doi: 10.1128/AAC.00488-13. Epub 2013 Aug 26.


Distinctive subcellular Akt-1 responses to shear stress in endothelial cells.

Melchior B, Frangos JA.

J Cell Biochem. 2014 Jan;115(1):121-9. doi: 10.1002/jcb.24639.


Nitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malaria.

Ong PK, Melchior B, Martins YC, Hofer A, Orjuela-Sánchez P, Cabrales P, Zanini GM, Frangos JA, Carvalho LJ.

PLoS Pathog. 2013;9(6):e1003444. doi: 10.1371/journal.ppat.1003444. Epub 2013 Jun 20.


Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria.

Martins YC, Clemmer L, Orjuela-Sánchez P, Zanini GM, Ong PK, Frangos JA, Carvalho LJ.

Malar J. 2013 Apr 24;12:138. doi: 10.1186/1475-2875-12-138.


Early VEGFR2 activation in response to flow is VEGF-dependent and mediated by MMP activity.

dela Paz NG, Melchior B, Frangos JA.

Biochem Biophys Res Commun. 2013 May 10;434(3):641-6. doi: 10.1016/j.bbrc.2013.03.134. Epub 2013 Apr 10.


A chronic scheme of cranial window preparation to study pial vascular reactivity in murine cerebral malaria.

Ong PK, Meays D, Frangos JA, Carvalho LJ.

Microcirculation. 2013 Jul;20(5):394-404. doi: 10.1111/micc.12034.


A lactate dehydrogenase ELISA-based assay for the in vitro determination of Plasmodium berghei sensitivity to anti-malarial drugs.

Orjuela-Sánchez P, Duggan E, Nolan J, Frangos JA, Carvalho LJ.

Malar J. 2012 Nov 5;11:366. doi: 10.1186/1475-2875-11-366.


Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells.

Melchior B, Frangos JA.

Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C467-73. doi: 10.1152/ajpcell.00117.2012. Epub 2012 Jun 13.


Skeletal adaptation to intramedullary pressure-induced interstitial fluid flow is enhanced in mice subjected to targeted osteocyte ablation.

Kwon RY, Meays DR, Meilan AS, Jones J, Miramontes R, Kardos N, Yeh JC, Frangos JA.

PLoS One. 2012;7(3):e33336. doi: 10.1371/journal.pone.0033336. Epub 2012 Mar 7.


S-nitrosoglutathione prevents experimental cerebral malaria.

Zanini GM, Martins YC, Cabrales P, Frangos JA, Carvalho LJ.

J Neuroimmune Pharmacol. 2012 Jun;7(2):477-87. doi: 10.1007/s11481-012-9343-6. Epub 2012 Mar 6.


Efficacy of different nitric oxide-based strategies in preventing experimental cerebral malaria by Plasmodium berghei ANKA.

Martins YC, Zanini GM, Frangos JA, Carvalho LJ.

PLoS One. 2012;7(2):e32048. doi: 10.1371/journal.pone.0032048. Epub 2012 Feb 13.


Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice.

Zanini GM, Cabrales P, Barkho W, Frangos JA, Carvalho LJ.

J Neuroinflammation. 2011 Jun 7;8:66. doi: 10.1186/1742-2094-8-66.

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