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Pulmonary Hypertension Therapy and a Systematic Review of Efficacy and Safety of PDE-5 Inhibitors.

Unegbu C, Noje C, Coulson JD, Segal JB, Romer L.

Pediatrics. 2017 Mar;139(3). pii: e20161450. doi: 10.1542/peds.2016-1450. Review.


Effect of calcium channel blockers evaluated by cardiopulmonary exercise testing in idiopathic pulmonary arterial hypertension responding to acute pulmonary vasoreactivity testing.

Tang Y, Yao L, Liu Z, Ma X, Luo Q, Zhao Z, Huang Z, Tu L, Gao L, Jin Q, Ni X, Xiong C.

Pulm Pharmacol Ther. 2017 Apr;43:26-31. doi: 10.1016/j.pupt.2017.01.012. Epub 2017 Feb 1.


Tricuspid annular plane systolic excursion correlates with exercise capacity in a cohort of patients with hypoplastic left heart syndrome after Fontan operation.

Goldberg DJ, French B, Szwast AL, McBride MG, Paridon SM, Rychik J, Mercer-Rosa L.

Echocardiography. 2016 Dec;33(12):1897-1902. doi: 10.1111/echo.13348. Epub 2016 Sep 5.


Sildenafil and Exercise Capacity in the Elderly at Moderate Altitude.

Rodway GW, Lovelace AJ, Lanspa MJ, McIntosh SE, Bell J, Briggs B, Weaver LK, Yanowitz F, Grissom CK.

Wilderness Environ Med. 2016 Jun;27(2):307-15. doi: 10.1016/j.wem.2016.01.006. Epub 2016 Apr 23.


[Sildenafil and exercise performance at altitude].

Peidro RM.

Medicina (B Aires). 2015;75(4):258-61. Spanish.


Effects of sildenafil on invasive haemodynamics and exercise capacity in heart failure patients with preserved ejection fraction and pulmonary hypertension: a randomized controlled trial.

Hoendermis ES, Liu LC, Hummel YM, van der Meer P, de Boer RA, Berger RM, van Veldhuisen DJ, Voors AA.

Eur Heart J. 2015 Oct 7;36(38):2565-73. doi: 10.1093/eurheartj/ehv336. Epub 2015 Jul 17.


Pulmonary vascular and right ventricular reserve in patients with normalized resting hemodynamics after pulmonary endarterectomy.

Claessen G, La Gerche A, Dymarkowski S, Claus P, Delcroix M, Heidbuchel H.

J Am Heart Assoc. 2015 Mar 23;4(3):e001602. doi: 10.1161/JAHA.114.001602.


Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure).

AbouEzzeddine OF, Haines P, Stevens S, Nativi-Nicolau J, Felker GM, Borlaug BA, Chen HH, Tracy RP, Braunwald E, Redfield MM.

JACC Heart Fail. 2015 Mar;3(3):245-52. doi: 10.1016/j.jchf.2014.10.009.


Sildenafil improves skeletal muscle oxygenation during exercise in men with intermittent claudication.

Roseguini BT, Hirai DM, Alencar MC, Ramos RP, Silva BM, Wolosker N, Neder JA, Nery LE.

Am J Physiol Regul Integr Comp Physiol. 2014 Aug 15;307(4):R396-404. doi: 10.1152/ajpregu.00183.2014. Epub 2014 Jun 18.


Dyspnea in Eisenmenger syndrome and its amelioration by sildenafil: role of J receptors.

Anand A, Srivastava N, Barwad P, Ramakrishnan S, Roy A, Bhargava B.

Int J Cardiol. 2014 Jul 1;174(3):574-8. doi: 10.1016/j.ijcard.2014.04.131. Epub 2014 Apr 21.


Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice.

Weissmann N, Peters DM, Klöpping C, Krüger K, Pilat C, Katta S, Seimetz M, Ghofrani HA, Schermuly RT, Witzenrath M, Seeger W, Grimminger F, Mooren FC.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L986-95. doi: 10.1152/ajplung.00275.2013. Epub 2014 Apr 4.


Predictors of sildenafil effects on exercise capacity in adolescents and adults with Fontan circulation.

Hager A, Weber R, Müller J, Hess J.

Clin Res Cardiol. 2014 Aug;103(8):641-6. doi: 10.1007/s00392-014-0694-2. Epub 2014 Mar 18.


Additional use of a phosphodiesterase 5 inhibitor in patients with pulmonary hypertension secondary to chronic systolic heart failure: a meta-analysis.

Wu X, Yang T, Zhou Q, Li S, Huang L.

Eur J Heart Fail. 2014 Apr;16(4):444-53. doi: 10.1002/ejhf.47. Epub 2013 Dec 31.


Impact of atrial fibrillation on exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study.

Zakeri R, Borlaug BA, McNulty SE, Mohammed SF, Lewis GD, Semigran MJ, Deswal A, LeWinter M, Hernandez AF, Braunwald E, Redfield MM.

Circ Heart Fail. 2014 Jan;7(1):123-30. doi: 10.1161/CIRCHEARTFAILURE.113.000568. Epub 2013 Oct 25.


Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.

Redfield MM, Chen HH, Borlaug BA, Semigran MJ, Lee KL, Lewis G, LeWinter MM, Rouleau JL, Bull DA, Mann DL, Deswal A, Stevenson LW, Givertz MM, Ofili EO, O'Connor CM, Felker GM, Goldsmith SR, Bart BA, McNulty SE, Ibarra JC, Lin G, Oh JK, Patel MR, Kim RJ, Tracy RP, Velazquez EJ, Anstrom KJ, Hernandez AF, Mascette AM, Braunwald E; RELAX Trial.

JAMA. 2013 Mar 27;309(12):1268-77. doi: 10.1001/jama.2013.2024.


Phosphodiesterase type 5 inhibition improves arterial stiffness after exercise but not exercise capacity in hypertensive men.

Attinà TM, Drummond ID, Malatino LS, Maxwell SR, Webb DJ.

Am J Hypertens. 2013 Mar;26(3):342-50. doi: 10.1093/ajh/hps057. Epub 2013 Jan 7.


Sildenafil improves microvascular O2 delivery-to-utilization matching and accelerates exercise O2 uptake kinetics in chronic heart failure.

Sperandio PA, Oliveira MF, Rodrigues MK, Berton DC, Treptow E, Nery LE, Almeida DR, Neder JA.

Am J Physiol Heart Circ Physiol. 2012 Dec 15;303(12):H1474-80. doi: 10.1152/ajpheart.00435.2012. Epub 2012 Sep 28.


PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) trial: rationale and design.

Redfield MM, Borlaug BA, Lewis GD, Mohammed SF, Semigran MJ, Lewinter MM, Deswal A, Hernandez AF, Lee KL, Braunwald E; Heart Failure Clinical Research Network.

Circ Heart Fail. 2012 Sep 1;5(5):653-9. No abstract available.


Lack of tight association between quality of life and exercise capacity in pulmonary arterial hypertension.

Cícero C, Franchi SM, Barreto AC, Lopes AA.

Arq Bras Cardiol. 2012 Oct;99(4):876-85. Epub 2012 Aug 30. English, Portuguese.

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