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Wei Sheng Yan Jiu. 2011 Mar;40(2):154-7.

[A case-control study between gene polymorphisms of polyunsaturated fatty acids metabolic rate-limiting enzymes and paranoid schizophrenia of Han ethnicity in Jilin Province].

[Article in Chinese]

Author information

1
School of Public Health, Jilin University, Changchun 130021, China.

Abstract

OBJECTIVE:

To investigate an association between gene polymorphisms of FADS 1 (fatty acid desaturase 1) , FADS2 (fatty acid desaturase 2) and ELOVL2 (elongation of very long chain fatty acids (FEN1/ Elo2, SUR4/Elo3, yeast) -like 2) and paranoid schizophrenia of the Han ethnicity in Jilin province of China.

METHODS:

We genotyped 3 single nucleotide polymorphisms from 3 candidate genes in 100 paranoid schizophrenia cases and 95 healthy controls using polymerase chain reaction-restriction fragment length polymorphism method. All samples are from Han ethnicity in Jilin province of China.

RESULTS:

The genotype distributions of rs174556 in FADS1 gene and rs174617 in FADS2 gene showed no significant difference between case and control groups (P > 0.05). The genotype distribution of rs3756963 in ELOVL2 gene showed significant difference between case group and control group (P < 0.05). The distribution proportion of allele T carriers in case group was higher than that in control group. Trans-phase gene interaction analysis showed that the distribution proportion of combined genotypes included rs3756963 (T/T) was higher in case group than that in control group (P < 0.05).

CONCLUSION:

rs174556 in FADS1 gene and rs174617 in FADS2 gene may not be associated with paranoid schizophrenia. rs3756963 in ELOVL2 gene may be associated with paranoid schizophrenia.

PMID:
21560298
[Indexed for MEDLINE]

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