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Items: 16


Disrupted-in-schizophrenia-1 protects synaptic plasticity in a transgenic mouse model of Alzheimer's disease as a mitophagy receptor.

Wang ZT, Lu MH, Zhang Y, Ji WL, Lei L, Wang W, Fang LP, Wang LW, Yu F, Wang J, Li ZY, Wang JR, Wang TH, Dou F, Wang QW, Wang XL, Li S, Ma QH, Xu RX.

Aging Cell. 2018 Nov 28:e12860. doi: 10.1111/acel.12860. [Epub ahead of print]


Protein misassembly and aggregation as potential convergence points for non-genetic causes of chronic mental illness.

Bradshaw NJ, Korth C.

Mol Psychiatry. 2018 Aug 8. doi: 10.1038/s41380-018-0133-2. [Epub ahead of print] Review.


A Mutation in NPAS3 That Segregates with Schizophrenia in a Small Family Leads to Protein Aggregation.

Nucifora LG, Wu YC, Lee BJ, Sha L, Margolis RL, Ross CA, Sawa A, Nucifora FC Jr.

Mol Neuropsychiatry. 2016 Oct;2(3):133-144. Epub 2016 Jul 27.


Association of DISC1 Polymorphisms with Late-Onset Alzheimer's Disease in Northern Han Chinese.

Zhang XY, Wang HF, Tan MS, Wan Y, Kong LL, Zheng ZJ, Tan CC, Zhang W, Wang ZX, Tan L, Jiang T, Tan L, Yu JT.

Mol Neurobiol. 2017 May;54(4):2922-2927. doi: 10.1007/s12035-016-9881-7. Epub 2016 Mar 29.


Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health.

Ordemann JM, Austin RN.

Metallomics. 2016 Jun 1;8(6):579-88. doi: 10.1039/c5mt00300h. Review.


Disrupted-in-Schizophrenia-1 Attenuates Amyloid-β Generation and Cognitive Deficits in APP/PS1 Transgenic Mice by Reduction of β-Site APP-Cleaving Enzyme 1 Levels.

Deng QS, Dong XY, Wu H, Wang W, Wang ZT, Zhu JW, Liu CF, Jia WQ, Zhang Y, Schachner M, Ma QH, Xu RX.

Neuropsychopharmacology. 2016 Jan;41(2):440-53. doi: 10.1038/npp.2015.164. Epub 2015 Jun 11.


[Role of oxidative stress in the pathophysiology of neuropsychiatric disorders].

Nunomura A, Tamaoki T, Motohashi N.

Seishin Shinkeigaku Zasshi. 2014;116(10):842-58. Japanese.


Viral capsid assembly as a model for protein aggregation diseases: Active processes catalyzed by cellular assembly machines comprising novel drug targets.

Marreiros R, Müller-Schiffmann A, Bader V, Selvarajah S, Dey D, Lingappa VR, Korth C.

Virus Res. 2015 Sep 2;207:155-64. doi: 10.1016/j.virusres.2014.10.003. Epub 2014 Oct 25. Review.


DISC1 regulates trafficking and processing of APP and Aβ generation.

Shahani N, Seshadri S, Jaaro-Peled H, Ishizuka K, Hirota-Tsuyada Y, Wang Q, Koga M, Sedlak TW, Korth C, Brandon NJ, Kamiya A, Subramaniam S, Tomoda T, Sawa A.

Mol Psychiatry. 2015 Jul;20(7):874-9. doi: 10.1038/mp.2014.100. Epub 2014 Sep 16.


Protection of Radial Glial-Like Cells in the Hippocampus of APP/PS1 Mice: a Novel Mechanism of Memantine in the Treatment of Alzheimer's Disease.

Sun D, Chen J, Bao X, Cai Y, Zhao J, Huang J, Huang W, Fan X, Xu H.

Mol Neurobiol. 2015 Aug;52(1):464-77. doi: 10.1007/s12035-014-8875-6. Epub 2014 Sep 9.


Gene therapy for psychiatric disorders.

Gelfand Y, Kaplitt MG.

World Neurosurg. 2013 Sep-Oct;80(3-4):S32.e11-8. doi: 10.1016/j.wneu.2012.12.028. Epub 2012 Dec 23. Review.


Most reported genetic associations with general intelligence are probably false positives.

Chabris CF, Hebert BM, Benjamin DJ, Beauchamp J, Cesarini D, van der Loos M, Johannesson M, Magnusson PK, Lichtenstein P, Atwood CS, Freese J, Hauser TS, Hauser RM, Christakis N, Laibson D.

Psychol Sci. 2012;23(11):1314-23. doi: 10.1177/0956797611435528. Epub 2012 Sep 24.


Generation, purification, and characterization of cell-invasive DISC1 protein species.

Bader V, Ottis P, Pum M, Huston JP, Korth C.

J Vis Exp. 2012 Aug 30;(66):e4132. doi: 10.3791/4132.


Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction.

Ayalew M, Le-Niculescu H, Levey DF, Jain N, Changala B, Patel SD, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger JI, Corvin A, Geyer M, Tsuang MT, Salomon D, Schork NJ, Fanous AH, O'Donovan MC, Niculescu AB.

Mol Psychiatry. 2012 Sep;17(9):887-905. doi: 10.1038/mp.2012.37. Epub 2012 May 15.


Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development.

Young-Pearse TL, Suth S, Luth ES, Sawa A, Selkoe DJ.

J Neurosci. 2010 Aug 4;30(31):10431-40. doi: 10.1523/JNEUROSCI.1445-10.2010.


Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936.

Houlihan LM, Harris SE, Luciano M, Gow AJ, Starr JM, Visscher PM, Deary IJ.

Genes Brain Behav. 2009 Mar;8(2):238-47. doi: 10.1111/j.1601-183X.2008.00470.x. Epub 2008 Dec 10.

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