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Items: 1 to 20 of 276

1.

Half-sandwich Os(ii) and Ru(ii) bathophenanthroline complexes: anticancer drug candidates with unusual potency and a cellular activity profile in highly invasive triple-negative breast cancer cells.

Pracharova J, Novohradsky V, Kostrhunova H, Štarha P, Trávníček Z, Kasparkova J, Brabec V.

Dalton Trans. 2018 Aug 16. doi: 10.1039/c8dt02236d. [Epub ahead of print]

PMID:
30112527
2.
3.

The Role of Pyruvate Dehydrogenase Kinase-4 (PDK4) in Bladder Cancer and Chemoresistance.

Woolbright BL, Choudhary D, Mikhalyuk A, Trammel C, Shanmugam S, Abbott E, Pilbeam CC, Taylor JA 3rd.

Mol Cancer Ther. 2018 Jun 15. doi: 10.1158/1535-7163.MCT-18-0063. [Epub ahead of print]

PMID:
29907593
4.

Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium(I)-DCA conjugate.

Yang J, Cao Q, Zhang H, Hao L, Zhou D, Gan Z, Li Z, Tong YX, Ji LN, Mao ZW.

Biomaterials. 2018 Sep;176:94-105. doi: 10.1016/j.biomaterials.2018.05.040. Epub 2018 May 25.

PMID:
29870900
5.

18F-EF5 PET-based Imageable Hypoxia Predicts Local Recurrence in Tumors Treated With Highly Conformal Radiation Therapy.

Qian Y, Von Eyben R, Liu Y, Chin FT, Miao Z, Apte S, Carter JN, Binkley MS, Pollom EL, Harris JP, Prionas ND, Kissel M, Simmons A, Diehn M, Shultz DB, Brown JM, Maxim PG, Koong AC, Graves EE, Loo BW Jr.

Int J Radiat Oncol Biol Phys. 2018 Apr 18. pii: S0360-3016(18)30596-0. doi: 10.1016/j.ijrobp.2018.03.045. [Epub ahead of print]

PMID:
29859786
6.

Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.

Zhong G, James MO, Smeltz MG, Jahn SC, Langaee T, Simpson P, Stacpoole PW.

Drug Metab Dispos. 2018 Aug;46(8):1118-1128. doi: 10.1124/dmd.118.081810. Epub 2018 May 31.

PMID:
29853471
7.

Modulation of Immuno-biome during radio-sensitization of tumors by glycolytic inhibitors.

Gupta S, Dwarakanath B.

Curr Med Chem. 2018 May 31. doi: 10.2174/0929867325666180601101145. [Epub ahead of print]

PMID:
29852858
8.

Dichloroacetate enhances the antitumor efficacy of chemotherapeutic agents via inhibiting autophagy in non-small-cell lung cancer.

Lu X, Zhou D, Hou B, Liu QX, Chen Q, Deng XF, Yu ZB, Dai JG, Zheng H.

Cancer Manag Res. 2018 May 16;10:1231-1241. doi: 10.2147/CMAR.S156530. eCollection 2018.

9.

Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance.

Petruzzella E, Sirota R, Solazzo I, Gandin V, Gibson D.

Chem Sci. 2018 Apr 24;9(18):4299-4307. doi: 10.1039/c8sc00428e. eCollection 2018 May 14.

10.

Dual-acting antitumor Pt(iv) prodrugs of kiteplatin with dichloroacetate axial ligands.

Savino S, Gandin V, Hoeschele JD, Marzano C, Natile G, Margiotta N.

Dalton Trans. 2018 May 29;47(21):7144-7158. doi: 10.1039/c8dt00686e.

PMID:
29766157
11.

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes.

Cunha-Oliveira T, Ferreira LL, Coelho AR, Deus CM, Oliveira PJ.

Toxicol Appl Pharmacol. 2018 Jun 1;348:1-13. doi: 10.1016/j.taap.2018.04.009. Epub 2018 Apr 11.

PMID:
29653124
12.

A facile doxorubicin-dichloroacetate conjugate nanomedicine with high drug loading for safe drug delivery.

Yang C, Wu T, Qin Y, Qi Y, Sun Y, Kong M, Jiang X, Qin X, Shen Y, Zhang Z.

Int J Nanomedicine. 2018 Mar 6;13:1281-1293. doi: 10.2147/IJN.S154361. eCollection 2018.

13.

Bidesmosidic betulin saponin bearing L-rhamnopyranoside moieties induces apoptosis and inhibition of lung cancer cells growth in vitro and in vivo.

Mihoub M, Pichette A, Sylla B, Gauthier C, Legault J.

PLoS One. 2018 Mar 14;13(3):e0193386. doi: 10.1371/journal.pone.0193386. eCollection 2018.

14.

A Comparative QSAR Analysis, Molecular Docking and PLIF Studies of Some N-arylphenyl-2, 2-Dichloroacetamide Analogues as Anticancer Agents.

Fereidoonnezhad M, Faghih Z, Mojaddami A, Rezaei Z, Sakhteman A.

Iran J Pharm Res. 2017 Summer;16(3):981-998.

15.

Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles.

Abánades Lázaro I, Abánades Lázaro S, Forgan RS.

Chem Commun (Camb). 2018 Mar 13;54(22):2792-2795. doi: 10.1039/c7cc09739e.

PMID:
29485148
16.

Half-Sandwich Ru(II) and Os(II) Bathophenanthroline Complexes Containing a Releasable Dichloroacetato Ligand.

Štarha P, Trávníček Z, Vančo J, Dvořák Z.

Molecules. 2018 Feb 14;23(2). pii: E420. doi: 10.3390/molecules23020420.

17.

Vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism.

Dirckx N, Tower RJ, Mercken EM, Vangoitsenhoven R, Moreau-Triby C, Breugelmans T, Nefyodova E, Cardoen R, Mathieu C, Van der Schueren B, Confavreux CB, Clemens TL, Maes C.

J Clin Invest. 2018 Mar 1;128(3):1087-1105. doi: 10.1172/JCI97794. Epub 2018 Feb 12.

18.

Changes in metabolism affect expression of ABC transporters through ERK5 and depending on p53 status.

Belkahla S, Haq Khan AU, Gitenay D, Alexia C, Gondeau C, Vo DN, Orecchioni S, Talarico G, Bertolini F, Cartron G, Hernandez J, Daujat-Chavanieu M, Allende-Vega N, Gonzalez MV.

Oncotarget. 2017 Dec 14;9(1):1114-1129. doi: 10.18632/oncotarget.23305. eCollection 2018 Jan 2.

19.

Mechanistic Investigation into the Selective Anticancer Cytotoxicity and Immune System Response of Surface-Functionalized, Dichloroacetate-Loaded, UiO-66 Nanoparticles.

Abánades Lázaro I, Haddad S, Rodrigo-Muñoz JM, Orellana-Tavra C, Del Pozo V, Fairen-Jimenez D, Forgan RS.

ACS Appl Mater Interfaces. 2018 Feb 14;10(6):5255-5268. doi: 10.1021/acsami.7b17756. Epub 2018 Feb 2.

PMID:
29356507
20.

Dichloroacetate induced intracellular acidification in glioblastoma: in vivo detection using AACID-CEST MRI at 9.4 Tesla.

Albatany M, Li A, Meakin S, Bartha R.

J Neurooncol. 2018 Jan;136(2):255-262. doi: 10.1007/s11060-017-2664-9. Epub 2017 Nov 16.

PMID:
29143921

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