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Best matches for dichloroacetate cancer:

Dichloroacetate and cancer: new home for an orphan drug? Kankotia S et al. Biochim Biophys Acta. (2014)

Dichloroacetate and Salinomycin Exert a Synergistic Cytotoxic Effect in Colorectal Cancer Cell Lines. Skeberdytė A et al. Sci Rep. (2018)

Sensitization of breast cancer cells to paclitaxel by dichloroacetate through inhibiting autophagy. Wang M et al. Biochem Biophys Res Commun. (2017)

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Items: 1 to 20 of 311


Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway.

Liang Y, Hou L, Li L, Li L, Zhu L, Wang Y, Huang X, Hou Y, Zhu D, Zou H, Gu Y, Weng X, Wang Y, Li Y, Wu T, Yao M, Gross I, Gaiddon C, Luo M, Wang J, Meng X.

Oncogene. 2019 Oct 9. doi: 10.1038/s41388-019-1035-8. [Epub ahead of print]


An anticancer Os(II) bathophenanthroline complex as a human breast cancer stem cell-selective, mammosphere potent agent that kills cells by necroptosis.

Novohradsky V, Markova L, Kostrhunova H, Trávníček Z, Brabec V, Kasparkova J.

Sci Rep. 2019 Sep 16;9(1):13327. doi: 10.1038/s41598-019-49774-x.


Mitochondrial Glutathione Transferase Zeta 1 Is Inactivated More Rapidly by Dichloroacetate than the Cytosolic Enzyme in Adult and Juvenile Rat Liver.

Smeltz MG, Hu Z, Zhong G, Jahn SC, Rowland-Faux L, Horne LP, Stacpoole PW, James MO.

Chem Res Toxicol. 2019 Oct 1. doi: 10.1021/acs.chemrestox.9b00207. [Epub ahead of print]


De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy.

Andrejeva G, Gowan S, Lin G, Wong Te Fong AL, Shamsaei E, Parkes HG, Mui J, Raynaud FI, Asad Y, Vizcay-Barrena G, Nikitorowicz-Buniak J, Valenti M, Howell L, Fleck RA, Martin LA, Kirkin V, Leach MO, Chung YL.

Autophagy. 2019 Sep 13:1-17. doi: 10.1080/15548627.2019.1659608. [Epub ahead of print]


Natural Product Albiziabioside A Conjugated with Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate To Induce Apoptosis-Ferroptosis-M2-TAMs Polarization for Combined Cancer Therapy.

Wei G, Sun J, Luan W, Hou Z, Wang S, Cui S, Cheng M, Liu Y.

J Med Chem. 2019 Oct 10;62(19):8760-8772. doi: 10.1021/acs.jmedchem.9b00644. Epub 2019 Sep 27.


Design, synthesis, and in vitro biological evaluation of 14-hydroxytylophorine-dichloroacetate co-drugs as antiproliferative agents.

Omran Z, Alarja M, Abdalla AN, Ibrahim MM, Hossain MA, Chen L, Liu Y, Wang Q.

Chem Pharm Bull (Tokyo). 2019 Sep 6. doi: 10.1248/cpb.c19-00520. [Epub ahead of print]


The Importance of Gender-Related Anticancer Research on Mitochondrial Regulator Sodium Dichloroacetate in Preclinical Studies In Vivo.

Stakišaitis D, Juknevičienė M, Damanskienė E, Valančiūtė A, Balnytė I, Alonso MM.

Cancers (Basel). 2019 Aug 20;11(8). pii: E1210. doi: 10.3390/cancers11081210. Review.


Targeting reduced mitochondrial DNA quantity as a therapeutic approach in pediatric high-grade gliomas.

Shen H, Yu M, Tsoli M, Chang C, Joshi S, Liu J, Ryall S, Chornenkyy Y, Siddaway R, Hawkins C, Ziegler DS.

Neuro Oncol. 2019 Aug 9. pii: noz140. doi: 10.1093/neuonc/noz140. [Epub ahead of print]


Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms.

Albatany M, Ostapchenko VG, Meakin S, Bartha R.

J Neurooncol. 2019 Sep;144(3):453-462. doi: 10.1007/s11060-019-03251-7. Epub 2019 Aug 7.


Temperature mapping of exothermic in situ chemistry: imaging of thermoembolization via MR.

Fahrenholtz SJ, Guo C, MacLellan CJ, Yung JP, Hwang KP, Layman RR, Stafford RJ, Cressman E.

Int J Hyperthermia. 2019;36(1):730-738. doi: 10.1080/02656736.2019.1635274.


Hyaluronan matrix inhibition enhances metabolic anticancer therapy by dichloroacetate in vitro and in vivo.

Twarock S, Reichert C, Bach K, Reiners O, Kretschmer I, Gorski DJ, Gorges K, Grandoch M, Fischer JW.

Br J Pharmacol. 2019 Jul 27. doi: 10.1111/bph.14808. [Epub ahead of print]


Mutations in the ND2 Subunit of Mitochondrial Complex I Are Sufficient to Confer Increased Tumorigenic and Metastatic Potential to Cancer Cells.

Marco-Brualla J, Al-Wasaby S, Soler R, Romanos E, Conde B, Justo-Méndez R, Enríquez JA, Fernández-Silva P, Martínez-Lostao L, Villalba M, Moreno-Loshuertos R, Anel A.

Cancers (Basel). 2019 Jul 21;11(7). pii: E1027. doi: 10.3390/cancers11071027.


Two dichloric compounds inhibit in vivo U87 xenograft tumor growth.

Ovcharenko D, Chitjian C, Kashkin A, Fanelli A, Ovcharenko V.

Cancer Biol Ther. 2019;20(9):1281-1289. doi: 10.1080/15384047.2019.1632131. Epub 2019 Jun 24.


Gender-Related Effect of Sodium Dichloroacetate on the Number of Hassall's Corpuscles and RNA NKCC1 Expression in Rat Thymus.

Stanevičiūtė J, Juknevičienė M, Balnytė I, Valančiūtė A, Lesauskaitė V, Fadejeva J, Stakauskas R, Stakišaitis D.

Biomed Res Int. 2019 Apr 24;2019:1602895. doi: 10.1155/2019/1602895. eCollection 2019.


Dichloroacetate Affects Mitochondrial Function and Stemness-Associated Properties in Pancreatic Cancer Cell Lines.

Tataranni T, Agriesti F, Pacelli C, Ruggieri V, Laurenzana I, Mazzoccoli C, Sala GD, Panebianco C, Pazienza V, Capitanio N, Piccoli C.

Cells. 2019 May 18;8(5). pii: E478. doi: 10.3390/cells8050478.


Inhibition of Pyruvate Dehydrogenase Kinase Enhances the Antitumor Efficacy of Oncolytic Reovirus.

Kennedy BE, Murphy JP, Clements DR, Konda P, Holay N, Kim Y, Pathak GP, Giacomantonio MA, Hiani YE, Gujar S.

Cancer Res. 2019 Aug 1;79(15):3824-3836. doi: 10.1158/0008-5472.CAN-18-2414. Epub 2019 May 14.


MiR-144 overexpression as a promising therapeutic strategy to overcome glioblastoma cell invasiveness and resistance to chemotherapy.

Cardoso AMS, Sousa M, Morais CM, Oancea-Castillo LR, Régnier-Vigouroux A, Rebelo O, Tão H, Barbosa M, Pedroso MCL, Jurado AS.

Hum Mol Genet. 2019 Aug 15;28(16):2738-2751. doi: 10.1093/hmg/ddz099.


Targeting Energy Metabolism by a Platinum(IV) Prodrug as an Alternative Pathway for Cancer Suppression.

Jin S, Guo Y, Song D, Zhu Z, Zhang Z, Sun Y, Yang T, Guo Z, Wang X.

Inorg Chem. 2019 May 6;58(9):6507-6516. doi: 10.1021/acs.inorgchem.9b00708. Epub 2019 Apr 23.


Inhibition of glycolysis disrupts cellular antioxidant defense and sensitizes HepG2 cells to doxorubicin treatment.

Korga A, Ostrowska M, Iwan M, Herbet M, Dudka J.

FEBS Open Bio. 2019 May;9(5):959-972. doi: 10.1002/2211-5463.12628. Epub 2019 Apr 11.


Metabolic stress controls mutant p53 R248Q stability in acute myeloid leukemia cells.

Allende-Vega N, Villalba M.

Sci Rep. 2019 Apr 4;9(1):5637. doi: 10.1038/s41598-019-42220-y.

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