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Items: 1 to 20 of 26

1.

Effect of Targeted Therapies on Prognostic Factors, Patterns of Care, and Survival in Patients With Renal Cell Carcinoma and Brain Metastases.

Sperduto PW, Deegan BJ, Li J, Jethwa KR, Brown PD, Lockney N, Beal K, Rana NG, Attia A, Tseng CL, Sahgal A, Shanley R, Sperduto WA, Lou E, Zahra A, Buatti JM, Yu JB, Chiang V, Molitoris JK, Masucci L, Roberge D, Shi DD, Shih HA, Olson A, Kirkpatrick JP, Braunstein S, Sneed P, Mehta MP.

Int J Radiat Oncol Biol Phys. 2018 Jul 15;101(4):845-853. doi: 10.1016/j.ijrobp.2018.04.006. Epub 2018 Apr 12.

PMID:
29976497
2.

pH modulates the binding of early growth response protein 1 transcription factor to DNA.

Mikles DC, Bhat V, Schuchardt BJ, Deegan BJ, Seldeen KL, McDonald CB, Farooq A.

FEBS J. 2013 Aug;280(15):3669-84. doi: 10.1111/febs.12360. Epub 2013 Jun 18.

3.

Heat-induced fibrillation of BclXL apoptotic repressor.

Bhat V, Olenick MB, Schuchardt BJ, Mikles DC, Deegan BJ, McDonald CB, Seldeen KL, Kurouski D, Faridi MH, Shareef MM, Gupta V, Lednev IK, Farooq A.

Biophys Chem. 2013 Sep;179:12-25. doi: 10.1016/j.bpc.2013.04.002. Epub 2013 May 7.

4.

Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factor.

McDonald CB, Bhat V, Kurouski D, Mikles DC, Deegan BJ, Seldeen KL, Lednev IK, Farooq A.

Biophys Chem. 2013 May-Jun;175-176:54-62. doi: 10.1016/j.bpc.2013.02.008. Epub 2013 Mar 5.

5.

Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.

McDonald CB, El Hokayem J, Zafar N, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A.

J Mol Recognit. 2013 Feb;26(2):92-103. doi: 10.1002/jmr.2256.

6.

Acidic pH promotes oligomerization and membrane insertion of the BclXL apoptotic repressor.

Bhat V, Kurouski D, Olenick MB, McDonald CB, Mikles DC, Deegan BJ, Seldeen KL, Lednev IK, Farooq A.

Arch Biochem Biophys. 2012 Dec 1;528(1):32-44. doi: 10.1016/j.abb.2012.08.009. Epub 2012 Aug 30.

7.

Biophysical basis of the binding of WWOX tumor suppressor to WBP1 and WBP2 adaptors.

McDonald CB, Buffa L, Bar-Mag T, Salah Z, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Malhotra A, Sudol M, Aqeilan RI, Nawaz Z, Farooq A.

J Mol Biol. 2012 Sep 7;422(1):58-74. doi: 10.1016/j.jmb.2012.05.015. Epub 2012 May 23.

8.

Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner.

McDonald CB, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A.

FEBS J. 2012 Jun;279(12):2156-73. doi: 10.1111/j.1742-4658.2012.08600.x. Epub 2012 May 9.

9.

Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner.

McDonald CB, Balke JE, Bhat V, Mikles DC, Deegan BJ, Seldeen KL, Farooq A.

Biochemistry. 2012 Mar 13;51(10):2122-35. doi: 10.1021/bi3000534. Epub 2012 Mar 2.

10.

Ligand binding and membrane insertion compete with oligomerization of the BclXL apoptotic repressor.

Bhat V, McDonald CB, Mikles DC, Deegan BJ, Seldeen KL, Bates ML, Farooq A.

J Mol Biol. 2012 Feb 10;416(1):57-77. doi: 10.1016/j.jmb.2011.12.015. Epub 2011 Dec 14.

11.

Structural and thermodynamic consequences of the replacement of zinc with environmental metals on estrogen receptor α-DNA interactions.

Deegan BJ, Bona AM, Bhat V, Mikles DC, McDonald CB, Seldeen KL, Farooq A.

J Mol Recognit. 2011 Nov-Dec;24(6):1007-17. doi: 10.1002/jmr.1148.

12.

Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.

McDonald CB, McIntosh SK, Mikles DC, Bhat V, Deegan BJ, Seldeen KL, Saeed AM, Buffa L, Sudol M, Nawaz Z, Farooq A.

Biochemistry. 2011 Nov 8;50(44):9616-27. doi: 10.1021/bi201286p. Epub 2011 Oct 14.

13.

Energetic coupling along an allosteric communication channel drives the binding of Jun-Fos heterodimeric transcription factor to DNA.

Seldeen KL, Deegan BJ, Bhat V, Mikles DC, McDonald CB, Farooq A.

FEBS J. 2011 Jun;278(12):2090-104. doi: 10.1111/j.1742-4658.2011.08124.x. Epub 2011 May 18.

14.

Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms.

McDonald CB, Seldeen KL, Deegan BJ, Bhat V, Farooq A.

J Mol Recognit. 2011 Jul-Aug;24(4):585-96. doi: 10.1002/jmr.1080. Epub 2010 Dec 13.

15.

Genetic variations within the ERE motif modulate plasticity and energetics of binding of DNA to the ERα nuclear receptor.

Deegan BJ, Bhat V, Seldeen KL, McDonald CB, Farooq A.

Arch Biochem Biophys. 2011 Mar 15;507(2):262-70. doi: 10.1016/j.abb.2011.01.002. Epub 2011 Jan 7.

16.

Binding of the ERalpha nuclear receptor to DNA is coupled to proton uptake.

Deegan BJ, Seldeen KL, McDonald CB, Bhat V, Farooq A.

Biochemistry. 2010 Jul 27;49(29):5978-88. doi: 10.1021/bi1004359.

17.

Dissecting the role of leucine zippers in the binding of bZIP domains of Jun transcription factor to DNA.

Seldeen KL, McDonald CB, Deegan BJ, Bhat V, Farooq A.

Biochem Biophys Res Commun. 2010 Apr 16;394(4):1030-5. doi: 10.1016/j.bbrc.2010.03.116. Epub 2010 Mar 21.

18.

Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control.

McDonald CB, Seldeen KL, Deegan BJ, Bhat V, Farooq A.

Arch Biochem Biophys. 2010 Feb 15;494(2):216-25. doi: 10.1016/j.abb.2009.12.011. Epub 2009 Dec 22.

19.

DNA plasticity is a key determinant of the energetics of binding of Jun-Fos heterodimeric transcription factor to genetic variants of TGACGTCA motif.

Seldeen KL, McDonald CB, Deegan BJ, Bhat V, Farooq A.

Biochemistry. 2009 Dec 29;48(51):12213-22. doi: 10.1021/bi901392k.

20.

SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner.

McDonald CB, Seldeen KL, Deegan BJ, Farooq A.

Biochemistry. 2009 May 19;48(19):4074-85. doi: 10.1021/bi802291y.

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