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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 2
1966 1
1967 1
1969 3
1970 2
1971 1
1972 2
1974 1
1975 5
1976 9
1977 7
1978 13
1979 16
1980 17
1981 20
1982 25
1983 33
1984 37
1985 43
1986 57
1987 54
1988 90
1989 90
1990 82
1991 96
1992 106
1993 102
1994 109
1995 125
1996 121
1997 139
1998 141
1999 148
2000 127
2001 155
2002 186
2003 186
2004 182
2005 206
2006 230
2007 249
2008 273
2009 280
2010 338
2011 339
2012 359
2013 400
2014 438
2015 464
2016 507
2017 544
2018 564
2019 608
2020 693
2021 630
2022 583
2023 544
2024 211

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9,811 results

Results by year

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The following terms were ignored: %, %, %, %
The following terms were not found in PubMed: 20Lemos, 20JA, 5BAuthor
Page 1
Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study.
Hasler F, Grimberg U, Benz MA, Huber T, Vollenweider FX. Hasler F, et al. Psychopharmacology (Berl). 2004 Mar;172(2):145-56. doi: 10.1007/s00213-003-1640-6. Epub 2003 Nov 13. Psychopharmacology (Berl). 2004. PMID: 14615876 Free article. Clinical Trial.
METHODS: Eight subjects received placebo (PL), and 45 ("very low dose, VLD"), 115 ("low dose, LD"), 215 ("medium dose, MD"), and 315 ("high dose, HD") microg/kg body weight PY. The "Altered States of Consciousness Rating Scale" (5D-ASC), the "Frankfurt Attention Inventory" …
METHODS: Eight subjects received placebo (PL), and 45 ("very low dose, VLD"), 115 ("low dose, LD"), 215 ("medium dose, MD"), and 315 ("high …
Anticonvulsant activity of 2-(substituted-imino)thiazolidin-4-ones.
Gong GH, Wang D, Zhang JF, Wei CX, Quan ZS. Gong GH, et al. Drug Res (Stuttg). 2014 Jan;64(1):5-9. doi: 10.1055/s-0033-1349095. Epub 2013 Aug 16. Drug Res (Stuttg). 2014. PMID: 23955391
The results of these tests demonstrated that 2-(4-(pentyloxy)phenylimino)thiazolidin-4-one (5d) was the most potent anticonvulsant, with ED50 value of 18.5 mg/kg and 15.3 mg/kg in the MES and Sc-PTZ tests, and protective index (PI=TD50/ED50) values of 10.6 and 12.8 respect …
The results of these tests demonstrated that 2-(4-(pentyloxy)phenylimino)thiazolidin-4-one (5d) was the most potent anticonvulsant, w …
Magnesium-based interventions for normal kidney function and chronic kidney disease.
Massy ZA, Nistor I, Apetrii M, Brandenburg VM, Bover J, Evenepoel P, Goldsmith D, Mazzaferro S, Urena-Torres P, Vervloet MG, Cozzolino M, Covic A, Era-Edta OB. Massy ZA, et al. Magnes Res. 2016 Apr 1;29(4):126-140. doi: 10.1684/mrh.2016.0412. Magnes Res. 2016. PMID: 28007671 Free article. Review.
We conducted a systematic search of studies assessing the benefits and harms of Mg in CKD (stages 1 to 5 and 5D), and considered all randomized controlled trials (RCTs) and quasi-RCTs evaluating Mg-based interventions in CKD. As a phosphate binder, Mg salts offer a plausib …
We conducted a systematic search of studies assessing the benefits and harms of Mg in CKD (stages 1 to 5 and 5D), and considered all …
Polyfluoroaromatic stavudine (d4T) ProTides exhibit enhanced anti-HIV activity.
Kandil S, Pannecouque C, Chapman FM, Westwell AD, McGuigan C. Kandil S, et al. Bioorg Med Chem Lett. 2019 Dec 15;29(24):126721. doi: 10.1016/j.bmcl.2019.126721. Epub 2019 Oct 23. Bioorg Med Chem Lett. 2019. PMID: 31679972
ProTide 5d has low nanomolar antiviral activity; (IC(50) = 30 nM, HIV-1) and (IC(50) = 36 nM, HIV-2) which is over tenfold more potent than d4T. Interestingly, ProTide 5d showed a significantly high selectivity indices with SI = 1753 (HIV-1) and 1461 (HIV-2) which i …
ProTide 5d has low nanomolar antiviral activity; (IC(50) = 30 nM, HIV-1) and (IC(50) = 36 nM, HIV-2) which is over tenfold more poten …
Does serelaxin treatment alter passive mechanical wall properties in small resistance arteries?
Jelinic M, Kahlberg N, Parry LJ, Tare M. Jelinic M, et al. Microcirculation. 2016 Nov;23(8):631-636. doi: 10.1111/micc.12321. Microcirculation. 2016. PMID: 27653183 Review.
Most studies in young rodents demonstrate that serelaxin treatment fails to alter passive compliance in resistance-size arteries (mesenteric and femoral arteries and cerebral parenchymal arterioles), suggesting that serelaxin's beneficial effects are minimal in healthy ani …
Most studies in young rodents demonstrate that serelaxin treatment fails to alter passive compliance in resistance-size arteries (mesenteric …
Tricyclic Triazoles as σ1 Receptor Antagonists for Treating Pain.
Díaz JL, Cuevas F, Oliva AI, Font D, Sarmentero MÁ, Álvarez-Bercedo P, López-Valbuena JM, Pericàs MA, Enrech R, Montero A, Yeste S, Vidal-Torres A, Álvarez I, Pérez P, Cendán CM, Cobos EJ, Vela JM, Almansa C. Díaz JL, et al. J Med Chem. 2021 Apr 22;64(8):5157-5170. doi: 10.1021/acs.jmedchem.1c00244. Epub 2021 Apr 7. J Med Chem. 2021. PMID: 33826322
Quinolone-N-acylhydrazone hybrids as potent Zika and Chikungunya virus inhibitors.
Marra RKF, Kümmerle AE, Guedes GP, Barros CS, Gomes RSP, Cirne-Santos CC, Paixão ICNP, Neves AP. Marra RKF, et al. Bioorg Med Chem Lett. 2020 Jan 15;30(2):126881. doi: 10.1016/j.bmcl.2019.126881. Epub 2019 Dec 9. Bioorg Med Chem Lett. 2020. PMID: 31843348
This work reports the synthesis of quinolone-N-acylhydrazone hybrids, namely 6-R-N'-(2-hydxoxybenzylidene)-4-oxo-1,4-dihydroquinoline-3-carbohydrazide (R = H: 5a, F: 5b, Cl: 5c and Br: 5d), which exhibited excellent activity against arbovirus Zika (ZIKV) and Chikungunya (C …
This work reports the synthesis of quinolone-N-acylhydrazone hybrids, namely 6-R-N'-(2-hydxoxybenzylidene)-4-oxo-1,4-dihydroquinoline-3-carb …
Synthesis and biological evaluation of amino acid derivatives containing chrysin that induce apoptosis.
Li Y, Zhang Q, He J, Yu W, Xiao J, Guo Y, Zhu X, Liu Y. Li Y, et al. Nat Prod Res. 2021 Feb;35(4):529-538. doi: 10.1080/14786419.2019.1582043. Epub 2019 Mar 21. Nat Prod Res. 2021. PMID: 30897948
Western blot analysis showed that 5d significantly inhibited Akt phosphorylation (Ser473) in MDA-MB-231 and MCF-7 cells. In addition, 5d treatment markedly downregulated Bcl-2 and upregulated Bax in a dose-dependent manner. ...
Western blot analysis showed that 5d significantly inhibited Akt phosphorylation (Ser473) in MDA-MB-231 and MCF-7 cells. In addition, …
Inotropic polyazapentalene sulmazole analogues.
Barraclough P, Black JW, Cambridge D, Firmin D, Gerskowitch VP, Glen RC, Giles H, Gillam JM, Hull RA, Iyer R, et al. Barraclough P, et al. Arch Pharm (Weinheim). 1992 Apr;325(4):225-34. doi: 10.1002/ardp.19923250407. Arch Pharm (Weinheim). 1992. PMID: 1530455
9,811 results