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Items: 1 to 20 of 146


Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity.

O'Reilly D, Kartje ZJ, Ageely EA, Malek-Adamian E, Habibian M, Schofield A, Barkau CL, Rohilla KJ, DeRossett LB, Weigle AT, Damha MJ, Gagnon KT.

Nucleic Acids Res. 2018 Dec 4. doi: 10.1093/nar/gky1214. [Epub ahead of print]


High-Density RNA Microarrays Synthesized In Situ by Photolithography.

Lietard J, Ameur D, Damha MJ, Somoza MM.

Angew Chem Int Ed Engl. 2018 Nov 12;57(46):15257-15261. doi: 10.1002/anie.201806895. Epub 2018 Oct 19.


Exploring Atypical Fluorine-Hydrogen Bonds and Their Effects on Nucleoside Conformations.

O'Reilly D, Stein RS, Patrascu MB, Jana SK, Kurian J, Moitessier N, Damha MJ.

Chemistry. 2018 Nov 2;24(61):16432-16439. doi: 10.1002/chem.201803940. Epub 2018 Oct 9.


i-Motif DNA: structural features and significance to cell biology.

Abou Assi H, Garavís M, González C, Damha MJ.

Nucleic Acids Res. 2018 Sep 19;46(16):8038-8056. doi: 10.1093/nar/gky735.


Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion.

Shen X, Kilikevicius A, O'Reilly D, Prakash TP, Damha MJ, Rigo F, Corey DR.

Bioorg Med Chem Lett. 2018 Sep 15;28(17):2850-2855. doi: 10.1016/j.bmcl.2018.07.033. Epub 2018 Jul 21.


Adjusting the Structure of 2'-Modified Nucleosides and Oligonucleotides via C4'-α-F or C4'-α-OMe Substitution: Synthesis and Conformational Analysis.

Malek-Adamian E, Patrascu MB, Jana SK, Martínez-Montero S, Moitessier N, Damha MJ.

J Org Chem. 2018 Sep 7;83(17):9839-9849. doi: 10.1021/acs.joc.8b01329. Epub 2018 Jul 17.


Synthesis of Chimeric Oligonucleotides Having Modified Internucleotide Linkages via an Automated H-Phosphonate/Phosphoramidite Approach.

Vlaho D, Damha MJ.

Curr Protoc Nucleic Acid Chem. 2018 Jun;73(1):e53. doi: 10.1002/cpnc.53. Epub 2018 Jun 14.


Two-step mechanism and step-arrest mutants of Runella slithyformis NAD+-dependent tRNA 2'-phosphotransferase Tpt1.

Munir A, Abdullahu L, Damha MJ, Shuman S.

RNA. 2018 Sep;24(9):1144-1157. doi: 10.1261/rna.067165.118. Epub 2018 Jun 8.


Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells.

Arnold AE, Malek-Adamian E, Le PU, Meng A, Martínez-Montero S, Petrecca K, Damha MJ, Shoichet MS.

Mol Ther Nucleic Acids. 2018 Jun 1;11:518-527. doi: 10.1016/j.omtn.2018.04.004. Epub 2018 Apr 19.


Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection.

Zhang SY, Clark NE, Freije CA, Pauwels E, Taggart AJ, Okada S, Mandel H, Garcia P, Ciancanelli MJ, Biran A, Lafaille FG, Tsumura M, Cobat A, Luo J, Volpi S, Zimmer B, Sakata S, Dinis A, Ohara O, Garcia Reino EJ, Dobbs K, Hasek M, Holloway SP, McCammon K, Hussong SA, DeRosa N, Van Skike CE, Katolik A, Lorenzo L, Hyodo M, Faria E, Halwani R, Fukuhara R, Smith GA, Galvan V, Damha MJ, Al-Muhsen S, Itan Y, Boeke JD, Notarangelo LD, Studer L, Kobayashi M, Diogo L, Fairbrother WG, Abel L, Rosenberg BR, Hart PJ, Etzioni A, Casanova JL.

Cell. 2018 Feb 22;172(5):952-965.e18. doi: 10.1016/j.cell.2018.02.019.


Structural properties and gene-silencing activity of chemically modified DNA-RNA hybrids with parallel orientation.

Habibian M, Yahyaee-Anzahaee M, Lucic M, Moroz E, Martín-Pintado N, Di Giovanni LD, Leroux JC, Hall J, González C, Damha MJ.

Nucleic Acids Res. 2018 Feb 28;46(4):1614-1623. doi: 10.1093/nar/gky024.


Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat.

Li L, Shen X, Liu Z, Norrbom M, Prakash TP, O'Reilly D, Sharma VK, Damha MJ, Watts JK, Rigo F, Corey DR.

Nucleic Acid Ther. 2018 Feb;28(1):23-33. doi: 10.1089/nat.2017.0703. Epub 2018 Jan 17.


Structural Studies and Gene Silencing Activity of siRNAs Containing Cationic Phosphoramidate Linkages.

Vlaho D, Fakhoury JF, Damha MJ.

Nucleic Acid Ther. 2018 Feb;28(1):34-43. doi: 10.1089/nat.2017.0702. Epub 2017 Dec 1.


Probing Synergistic Effects of DNA Methylation and 2'-β-Fluorination on i-Motif Stability.

Abou Assi H, Lin YC, Serrano I, González C, Damha MJ.

Chemistry. 2018 Jan 9;24(2):471-477. doi: 10.1002/chem.201704591. Epub 2017 Dec 6.


2'-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA.

Assi HA, El-Khoury R, González C, Damha MJ.

Nucleic Acids Res. 2017 Nov 16;45(20):12055. doi: 10.1093/nar/gkx962. No abstract available.


2'-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA.

Abou Assi H, El-Khoury R, González C, Damha MJ.

Nucleic Acids Res. 2017 Nov 16;45(20):11535-11546. doi: 10.1093/nar/gkx838.


4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.

Malek-Adamian E, Guenther DC, Matsuda S, Martínez-Montero S, Zlatev I, Harp J, Burai Patrascu M, Foster DJ, Fakhoury J, Perkins L, Moitessier N, Manoharan RM, Taneja N, Bisbe A, Charisse K, Maier M, Rajeev KG, Egli M, Manoharan M, Damha MJ.

J Am Chem Soc. 2017 Oct 18;139(41):14542-14555. doi: 10.1021/jacs.7b07582. Epub 2017 Oct 6.


Accurately Modeling the Conformational Preferences of Nucleosides.

Burai Patrascu M, Malek-Adamian E, Damha MJ, Moitessier N.

J Am Chem Soc. 2017 Oct 4;139(39):13620-13623. doi: 10.1021/jacs.7b07436. Epub 2017 Sep 25.


Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations.

Abbas YM, Laudenbach BT, Martínez-Montero S, Cencic R, Habjan M, Pichlmair A, Damha MJ, Pelletier J, Nagar B.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2106-E2115. doi: 10.1073/pnas.1612444114. Epub 2017 Mar 1.


Mapping the affinity landscape of Thrombin-binding aptamers on 2΄F-ANA/DNA chimeric G-Quadruplex microarrays.

Lietard J, Abou Assi H, Gómez-Pinto I, González C, Somoza MM, Damha MJ.

Nucleic Acids Res. 2017 Feb 28;45(4):1619-1632. doi: 10.1093/nar/gkw1357.

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