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Items: 1 to 20 of 131

1.

Automated Design of Pluripotent Stem Cell Self-Organization.

Libby ARG, Briers D, Haghighi I, Joy DA, Conklin BR, Belta C, McDevitt TC.

Cell Syst. 2019 Nov 27;9(5):483-495.e10. doi: 10.1016/j.cels.2019.10.008. Epub 2019 Nov 20.

PMID:
31759947
2.

AlleleAnalyzer: a tool for personalized and allele-specific sgRNA design.

Keough KC, Lyalina S, Olvera MP, Whalen S, Conklin BR, Pollard KS.

Genome Biol. 2019 Aug 15;20(1):167. doi: 10.1186/s13059-019-1783-3.

3.

Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells.

Yoshinaga D, Baba S, Makiyama T, Shibata H, Hirata T, Akagi K, Matsuda K, Kohjitani H, Wuriyanghai Y, Umeda K, Yamamoto Y, Conklin BR, Horie M, Takita J, Heike T.

Stem Cell Reports. 2019 Aug 13;13(2):394-404. doi: 10.1016/j.stemcr.2019.06.007. Epub 2019 Aug 1.

4.

Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes.

Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y.

Nat Genet. 2019 Aug;51(8):1252-1262. doi: 10.1038/s41588-019-0472-1. Epub 2019 Jul 31.

PMID:
31367015
5.

Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload.

Ma Z, Huebsch N, Koo S, Mandegar MA, Siemons B, Boggess S, Conklin BR, Grigoropoulos CP, Healy KE.

Nat Biomed Eng. 2018 Dec;2(12):955-967. doi: 10.1038/s41551-018-0280-4. Epub 2018 Sep 10.

6.

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq.

Wienert B, Wyman SK, Richardson CD, Yeh CD, Akcakaya P, Porritt MJ, Morlock M, Vu JT, Kazane KR, Watry HL, Judge LM, Conklin BR, Maresca M, Corn JE.

Science. 2019 Apr 19;364(6437):286-289. doi: 10.1126/science.aav9023. Epub 2019 Apr 18.

7.

On the road to a gene drive in mammals.

Conklin BR.

Nature. 2019 Feb;566(7742):43-45. doi: 10.1038/d41586-019-00185-y. No abstract available.

PMID:
30710124
8.

MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification.

Eskildsen TV, Ayoubi S, Thomassen M, Burton M, Mandegar MA, Conklin BR, Jensen CH, Andersen DC, Sheikh SP.

Dev Biol. 2019 Jan 1;445(1):1-7. doi: 10.1016/j.ydbio.2018.10.020. Epub 2018 Oct 31.

9.

Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.

Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC.

Elife. 2018 Oct 9;7. pii: e36045. doi: 10.7554/eLife.36045.

10.

Detection and Quantification of HDR and NHEJ Induced by Genome Editing at Endogenous Gene Loci Using Droplet Digital PCR.

Miyaoka Y, Mayerl SJ, Chan AH, Conklin BR.

Methods Mol Biol. 2018;1768:349-362. doi: 10.1007/978-1-4939-7778-9_20.

11.

Quantitatively characterizing drug-induced arrhythmic contractile motions of human stem cell-derived cardiomyocytes.

Hoang P, Huebsch N, Bang SH, Siemons BA, Conklin BR, Healy KE, Ma Z, Jacquir S.

Biotechnol Bioeng. 2018 Aug;115(8):1958-1970. doi: 10.1002/bit.26709. Epub 2018 Apr 27.

12.

Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells.

Hoang P, Wang J, Conklin BR, Healy KE, Ma Z.

Nat Protoc. 2018 Apr;13(4):723-737. doi: 10.1038/nprot.2018.006. Epub 2018 Mar 15.

13.

A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.

Judge LM, Perez-Bermejo JA, Truong A, Ribeiro AJ, Yoo JC, Jensen CL, Mandegar MA, Huebsch N, Kaake RM, So PL, Srivastava D, Pruitt BL, Krogan NJ, Conklin BR.

JCI Insight. 2017 Jul 20;2(14). pii: 94623. doi: 10.1172/jci.insight.94623. eCollection 2017 Jul 20.

14.

Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes.

Ribeiro AJS, Schwab O, Mandegar MA, Ang YS, Conklin BR, Srivastava D, Pruitt BL.

Circ Res. 2017 May 12;120(10):1572-1583. doi: 10.1161/CIRCRESAHA.116.310363. Epub 2017 Apr 11. Review.

15.

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.

Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, Weissman JS, Lim DA.

Science. 2017 Jan 6;355(6320). pii: aah7111. doi: 10.1126/science.aah7111. Epub 2016 Dec 15.

16.

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.

Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM.

Nat Med. 2017 Jan;23(1):49-59. doi: 10.1038/nm.4233. Epub 2016 Nov 21.

17.

BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence.

Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, Toguchida J, Conklin BR, Yamanaka S.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13057-13062. Epub 2016 Oct 28.

18.

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.

Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA.

Nat Commun. 2016 Jul 1;7:12009. doi: 10.1038/ncomms12009.

19.

Using Digital Polymerase Chain Reaction to Detect Single-Nucleotide Substitutions Induced by Genome Editing.

Miyaoka Y, Chan AH, Conklin BR.

Cold Spring Harb Protoc. 2016 Aug 1;2016(8). doi: 10.1101/pdb.prot086801.

PMID:
27250210
20.

Detecting Single-Nucleotide Substitutions Induced by Genome Editing.

Miyaoka Y, Chan AH, Conklin BR.

Cold Spring Harb Protoc. 2016 Aug 1;2016(8). doi: 10.1101/pdb.top090845.

PMID:
27250209

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