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Best matches for childhood obesity mc4r:

MeQTL analysis of childhood obesity links epigenetics with a risk SNP rs17782313 near MC4R from meta-analysis. Tang Y et al. Oncotarget. (2017)

Age of obesity onset in MC4R mutation carriers. Stanikova D et al. Endocr Regul. (2015)

New Insights Regarding Genetic Aspects of Childhood Obesity: A Minireview. Mǎrginean CO et al. Front Pediatr. (2018)

Search results

Items: 1 to 20 of 125

1.

Melanocortin-4 Receptor Signalling: Importance for Weight Regulation and Obesity Treatment.

Kühnen P, Krude H, Biebermann H.

Trends Mol Med. 2019 Feb;25(2):136-148. doi: 10.1016/j.molmed.2018.12.002. Epub 2019 Jan 11. Review.

PMID:
30642682
2.

Identification of novel LEPR mutations in Pakistani families with morbid childhood obesity.

Niazi RK, Gjesing AP, Hollensted M, Have CT, Grarup N, Pedersen O, Ullah A, Shahid G, Ahmad W, Gul A, Hansen T.

BMC Med Genet. 2018 Nov 15;19(1):199. doi: 10.1186/s12881-018-0710-x.

3.

New Insights Regarding Genetic Aspects of Childhood Obesity: A Minireview.

Mǎrginean CO, Mǎrginean C, Meliţ LE.

Front Pediatr. 2018 Oct 4;6:271. doi: 10.3389/fped.2018.00271. eCollection 2018. Review.

4.

Relevance of polymorphisms in MC4R and BDNF in short normal stature.

Herrfurth N, Volckmar AL, Peters T, Kleinau G, Müller A, Cetindag C, Schonnop L, Föcker M, Dempfle A, Wudy SA, Grant SFA, Reinehr T, Cousminer DL, Hebebrand J, Biebermann H, Hinney A.

BMC Pediatr. 2018 Aug 22;18(1):278. doi: 10.1186/s12887-018-1245-1.

5.

Genetic obesity: next-generation sequencing results of 1230 patients with obesity.

Kleinendorst L, Massink MPG, Cooiman MI, Savas M, van der Baan-Slootweg OH, Roelants RJ, Janssen ICM, Meijers-Heijboer HJ, Knoers NVAM, Ploos van Amstel HK, van Rossum EFC, van den Akker ELT, van Haaften G, van der Zwaag B, van Haelst MM.

J Med Genet. 2018 Sep;55(9):578-586. doi: 10.1136/jmedgenet-2018-105315. Epub 2018 Jul 3.

PMID:
29970488
6.

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.

Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P.

Nat Med. 2018 May;24(5):551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7.

PMID:
29736023
7.

Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children.

Almeida SM, Furtado JM, Mascarenhas P, Ferraz ME, Ferreira JC, Monteiro MP, Vilanova M, Ferraz FP.

Endocrine. 2018 Jun;60(3):466-478. doi: 10.1007/s12020-018-1587-3. Epub 2018 Apr 20.

8.

Pathophysiology of melanocortin receptors and their accessory proteins.

Novoselova TV, Chan LF, Clark AJL.

Best Pract Res Clin Endocrinol Metab. 2018 Apr;32(2):93-106. doi: 10.1016/j.beem.2018.02.002. Epub 2018 Feb 9. Review.

PMID:
29678289
9.

Association between the DNA methylations of POMC, MC4R, and HNF4A and metabolic profiles in the blood of children aged 7-9 years.

Kwon EJ, You YA, Park B, Ha EH, Kim HS, Park H, Kim YJ.

BMC Pediatr. 2018 Mar 29;18(1):121. doi: 10.1186/s12887-018-1104-0.

10.

Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency.

Kohlsdorf K, Nunziata A, Funcke JB, Brandt S, von Schnurbein J, Vollbach H, Lennerz B, Fritsch M, Greber-Platzer S, Fröhlich-Reiterer E, Luedeke M, Borck G, Debatin KM, Fischer-Posovszky P, Wabitsch M.

Int J Obes (Lond). 2018 Sep;42(9):1602-1609. doi: 10.1038/s41366-018-0049-6. Epub 2018 Feb 27.

PMID:
29568105
11.

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P, Ng MCY, Reiner AP, Vedantam S, Willems SM, Winkler TW, Abecasis G, Aben KK, Alam DS, Alharthi SE, Allison M, Amouyel P, Asselbergs FW, Auer PL, Balkau B, Bang LE, Barroso I, Bastarache L, Benn M, Bergmann S, Bielak LF, Blüher M, Boehnke M, Boeing H, Boerwinkle E, Böger CA, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Brumat M, Burt AA, Butterworth AS, Campbell PT, Cappellani S, Carey DJ, Catamo E, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Corominas Galbany J, Cox AJ, Crosslin DS, Cuellar-Partida G, D'Eustacchio A, Danesh J, Davies G, Bakker PIW, Groot MCH, Mutsert R, Deary IJ, Dedoussis G, Demerath EW, Heijer M, Hollander AI, Ruijter HM, Dennis JG, Denny JC, Di Angelantonio E, Drenos F, Du M, Dubé MP, Dunning AM, Easton DF, Edwards TL, Ellinghaus D, Ellinor PT, Elliott P, Evangelou E, Farmaki AE, Farooqi IS, Faul JD, Fauser S, Feng S, Ferrannini E, Ferrieres J, Florez JC, Ford I, Fornage M, Franco OH, Franke A, Franks PW, Friedrich N, Frikke-Schmidt R, Galesloot TE, Gan W, Gandin I, Gasparini P, Gibson J, Giedraitis V, Gjesing AP, Gordon-Larsen P, Gorski M, Grabe HJ, Grant SFA, Grarup N, Griffiths HL, Grove ML, Gudnason V, Gustafsson S, Haessler J, Hakonarson H, Hammerschlag AR, Hansen T, Harris KM, Harris TB, Hattersley AT, Have CT, Hayward C, He L, Heard-Costa NL, Heath AC, Heid IM, Helgeland Ø, Hernesniemi J, Hewitt AW, Holmen OL, Hovingh GK, Howson JMM, Hu Y, Huang PL, Huffman JE, Ikram MA, Ingelsson E, Jackson AU, Jansson JH, Jarvik GP, Jensen GB, Jia Y, Johansson S, Jørgensen ME, Jørgensen T, Jukema JW, Kahali B, Kahn RS, Kähönen M, Kamstrup PR, Kanoni S, Kaprio J, Karaleftheri M, Kardia SLR, Karpe F, Kathiresan S, Kee F, Kiemeney LA, Kim E, Kitajima H, Komulainen P, Kooner JS, Kooperberg C, Korhonen T, Kovacs P, Kuivaniemi H, Kutalik Z, Kuulasmaa K, Kuusisto J, Laakso M, Lakka TA, Lamparter D, Lange EM, Lange LA, Langenberg C, Larson EB, Lee NR, Lehtimäki T, Lewis CE, Li H, Li J, Li-Gao R, Lin H, Lin KH, Lin LA, Lin X, Lind L, Lindström J, Linneberg A, Liu CT, Liu DJ, Liu Y, Lo KS, Lophatananon A, Lotery AJ, Loukola A, Luan J, Lubitz SA, Lyytikäinen LP, Männistö S, Marenne G, Mazul AL, McCarthy MI, McKean-Cowdin R, Medland SE, Meidtner K, Milani L, Mistry V, Mitchell P, Mohlke KL, Moilanen L, Moitry M, Montgomery GW, Mook-Kanamori DO, Moore C, Mori TA, Morris AD, Morris AP, Müller-Nurasyid M, Munroe PB, Nalls MA, Narisu N, Nelson CP, Neville M, Nielsen SF, Nikus K, Njølstad PR, Nordestgaard BG, Nyholt DR, O'Connel JR, O'Donoghue ML, Olde Loohuis LM, Ophoff RA, Owen KR, Packard CJ, Padmanabhan S, Palmer CNA, Palmer ND, Pasterkamp G, Patel AP, Pattie A, Pedersen O, Peissig PL, Peloso GM, Pennell CE, Perola M, Perry JA, Perry JRB, Pers TH, Person TN, Peters A, Petersen ERB, Peyser PA, Pirie A, Polasek O, Polderman TJ, Puolijoki H, Raitakari OT, Rasheed A, Rauramaa R, Reilly DF, Renström F, Rheinberger M, Ridker PM, Rioux JD, Rivas MA, Roberts DJ, Robertson NR, Robino A, Rolandsson O, Rudan I, Ruth KS, Saleheen D, Salomaa V, Samani NJ, Sapkota Y, Sattar N, Schoen RE, Schreiner PJ, Schulze MB, Scott RA, Segura-Lepe MP, Shah SH, Sheu WH, Sim X, Slater AJ, Small KS, Smith AV, Southam L, Spector TD, Speliotes EK, Starr JM, Stefansson K, Steinthorsdottir V, Stirrups KE, Strauch K, Stringham HM, Stumvoll M, Sun L, Surendran P, Swift AJ, Tada H, Tansey KE, Tardif JC, Taylor KD, Teumer A, Thompson DJ, Thorleifsson G, Thorsteinsdottir U, Thuesen BH, Tönjes A, Tromp G, Trompet S, Tsafantakis E, Tuomilehto J, Tybjaerg-Hansen A, Tyrer JP, Uher R, Uitterlinden AG, Uusitupa M, Laan SW, Duijn CM, Leeuwen N, van Setten J, Vanhala M, Varbo A, Varga TV, Varma R, Velez Edwards DR, Vermeulen SH, Veronesi G, Vestergaard H, Vitart V, Vogt TF, Völker U, Vuckovic D, Wagenknecht LE, Walker M, Wallentin L, Wang F, Wang CA, Wang S, Wang Y, Ware EB, Wareham NJ, Warren HR, Waterworth DM, Wessel J, White HD, Willer CJ, Wilson JG, Witte DR, Wood AR, Wu Y, Yaghootkar H, Yao J, Yao P, Yerges-Armstrong LM, Young R, Zeggini E, Zhan X, Zhang W, Zhao JH, Zhao W, Zhao W, Zhou W, Zondervan KT, Rotter JI, Pospisilik JA, Rivadeneira F, Borecki IB, Deloukas P, Frayling TM, Lettre G, North KE, Lindgren CM, Hirschhorn JN, Loos RJF; CHD Exome+ Consortium; EPIC-CVD Consortium; ExomeBP Consortium; Global Lipids Genetic Consortium; GoT2D Genes Consortium; EPIC InterAct Consortium; INTERVAL Study; ReproGen Consortium; T2D-Genes Consortium; MAGIC Investigators; Understanding Society Scientific Group.

Nat Genet. 2018 Jan;50(1):26-41. doi: 10.1038/s41588-017-0011-x. Epub 2017 Dec 22. Erratum in: Nat Genet. 2018 Mar 16;:. Nat Genet. 2018 Mar 16;:.

12.

High Prevalence of Rare Monogenic Forms of Obesity in Obese Guadeloupean Afro-Caribbean Children.

Foucan L, Larifla L, Durand E, Rambhojan C, Armand C, Michel CT, Billy R, Dhennin V, De Graeve F, Rabearivelo I, Sand O, Lacorte JM, Froguel P, Bonnefond A.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):539-545. doi: 10.1210/jc.2017-01956.

PMID:
29216354
13.

The role of established East Asian obesity-related loci on pediatric leptin levels highlights a neuronal influence on body weight regulation in Chinese children and adolescents: the BCAMS study.

Fu J, Li G, Li L, Yin J, Cheng H, Han L, Zhang Q, Li N, Xiao X, Grant SFA, Li M, Gao S, Mi J, Li M.

Oncotarget. 2017 Aug 24;8(55):93593-93607. doi: 10.18632/oncotarget.20547. eCollection 2017 Nov 7.

14.

[Gene-gene interaction on central obesity in school-aged children in China].

Fu LW, Zhang MX, Wu LJ, Gao LW, Mi J.

Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Jul 10;38(7):883-888. doi: 10.3760/cma.j.issn.0254-6450.2017.07.007. Chinese.

PMID:
28738459
15.

Analysis of association of gene variants with obesity traits in New Zealand European children at 6 years of age.

Krishnan M, Thompson JMD, Mitchell EA, Murphy R, McCowan LME, Shelling AN, On Behalf Of The Children Of Scope Study Group G.

Mol Biosyst. 2017 Jul 25;13(8):1524-1533. doi: 10.1039/c7mb00104e.

PMID:
28636007
16.

Copy number variations in "classical" obesity candidate genes are not frequently associated with severe early-onset obesity in children.

Windholz J, Kovacs P, Schlicke M, Franke C, Mahajan A, Morris AP, Lemke JR, Klammt J, Kiess W, Schöneberg T, Pfäffle R, Körner A.

J Pediatr Endocrinol Metab. 2017 May 1;30(5):507-515. doi: 10.1515/jpem-2016-0435.

PMID:
28593922
17.

Hypothalamic Inflammation in Human Obesity Is Mediated by Environmental and Genetic Factors.

Kreutzer C, Peters S, Schulte DM, Fangmann D, Türk K, Wolff S, van Eimeren T, Ahrens M, Beckmann J, Schafmayer C, Becker T, Kerby T, Rohr A, Riedel C, Heinsen FA, Degenhardt F, Franke A, Rosenstiel P, Zubek N, Henning C, Freitag-Wolf S, Dempfle A, Psilopanagioti A, Petrou-Papadaki H, Lenk L, Jansen O, Schreiber S, Laudes M.

Diabetes. 2017 Sep;66(9):2407-2415. doi: 10.2337/db17-0067. Epub 2017 Jun 2.

18.

Melanocortin neurons: Multiple routes to regulation of metabolism.

Shen WJ, Yao T, Kong X, Williams KW, Liu T.

Biochim Biophys Acta Mol Basis Dis. 2017 Oct;1863(10 Pt A):2477-2485. doi: 10.1016/j.bbadis.2017.05.007. Epub 2017 May 9. Review.

19.

Genetic analysis of single-minded 1 gene in early-onset severely obese children and adolescents.

Stanikova D, Buzga M, Krumpolec P, Skopkova M, Surova M, Ukropcova B, Ticha L, Petrasova M, Gabcova D, Huckova M, Piskorova L, Bozensky J, Mokan M, Ukropec J, Zavacka I, Klimes I, Stanik J, Gasperikova D.

PLoS One. 2017 May 4;12(5):e0177222. doi: 10.1371/journal.pone.0177222. eCollection 2017.

20.

Melanocortin-4 Receptor Gene Mutations in a Group of Turkish Obese Children and Adolescents.

Tunç S, Demir K, Tükün FA, Topal C, Hazan F, Sağlam B, Nalbantoğlu Ö, Yıldız M, Özkan B.

J Clin Res Pediatr Endocrinol. 2017 Sep 1;9(3):216-221. doi: 10.4274/jcrpe.4225. Epub 2017 Feb 20.

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