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Items: 1 to 20 of 33

1.

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.

Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P.

Nat Med. 2018 May;24(5):551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7.

PMID:
29736023
2.

Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children.

Almeida SM, Furtado JM, Mascarenhas P, Ferraz ME, Ferreira JC, Monteiro MP, Vilanova M, Ferraz FP.

Endocrine. 2018 Jun;60(3):466-478. doi: 10.1007/s12020-018-1587-3. Epub 2018 Apr 20.

3.

Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency.

Kohlsdorf K, Nunziata A, Funcke JB, Brandt S, von Schnurbein J, Vollbach H, Lennerz B, Fritsch M, Greber-Platzer S, Fröhlich-Reiterer E, Luedeke M, Borck G, Debatin KM, Fischer-Posovszky P, Wabitsch M.

Int J Obes (Lond). 2018 Feb 27. doi: 10.1038/s41366-018-0049-6. [Epub ahead of print]

PMID:
29568105
4.

Young girl with severe early-onset obesity and hyperphagia.

Kleinendorst L, van Haelst MM, van den Akker ELT.

BMJ Case Rep. 2017 Sep 25;2017. pii: bcr-2017-221067. doi: 10.1136/bcr-2017-221067.

PMID:
28951511
5.

Gene-by-Activity Interactions on Obesity Traits of 6-Year-Old New Zealand European Children: A Children of SCOPE Study.

Krishnan M, Shelling AN, Wall CR, Mitchell EA, Murphy R, McCowan LME, Thompson JMD; on behlaf of the Children of SCOPE Study Group.

Pediatr Exerc Sci. 2018 Feb 1;30(1):69-80. doi: 10.1123/pes.2017-0077. Epub 2017 Oct 17.

PMID:
28661716
6.

Copy number variations in "classical" obesity candidate genes are not frequently associated with severe early-onset obesity in children.

Windholz J, Kovacs P, Schlicke M, Franke C, Mahajan A, Morris AP, Lemke JR, Klammt J, Kiess W, Schöneberg T, Pfäffle R, Körner A.

J Pediatr Endocrinol Metab. 2017 May 1;30(5):507-515. doi: 10.1515/jpem-2016-0435.

PMID:
28593922
7.

Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children.

Antúnez-Ortiz DL, Flores-Alfaro E, Burguete-García AI, Bonnefond A, Peralta-Romero J, Froguel P, Espinoza-Rojo M, Cruz M.

Biomed Res Int. 2017;2017:2432957. doi: 10.1155/2017/2432957. Epub 2017 Mar 27.

8.

Genetic markers of inflammation may not contribute to metabolic traits in Mexican children.

Vashi N, Stryjecki C, Peralta-Romero J, Suarez F, Gomez-Zamudio J, Burguete-Garcia AI, Cruz M, Meyre D.

PeerJ. 2016 Jun 23;4:e2090. doi: 10.7717/peerj.2090. eCollection 2016.

9.

Complementary Effects of Genetic Variations in LEPR on Body Composition and Soluble Leptin Receptor Concentration after 3-Month Lifestyle Intervention in Prepubertal Obese Children.

Gajewska J, Kuryłowicz A, Mierzejewska E, Ambroszkiewicz J, Chełchowska M, Weker H, Puzianowska-Kuźnicka M.

Nutrients. 2016 May 27;8(6). pii: E328. doi: 10.3390/nu8060328.

10.
11.

Extreme obesity induces massive beta cell expansion in mice through self-renewal and does not alter the beta cell lineage.

Cox AR, Lam CJ, Rankin MM, King KA, Chen P, Martinez R, Li C, Kushner JA.

Diabetologia. 2016 Jun;59(6):1231-41. doi: 10.1007/s00125-016-3922-7. Epub 2016 Mar 22.

12.

Novel Leptin Receptor Mutations Identified in Two Girls with Severe Obesity Are Associated with Increased Bone Mineral Density.

Hannema SE, Wit JM, Houdijk ME, van Haeringen A, Bik EC, Verkerk AJ, Uitterlinden AG, Kant SG, Oostdijk W, Bakker E, Delemarre-van de Waal HA, Losekoot M.

Horm Res Paediatr. 2016;85(6):412-20. doi: 10.1159/000444055. Epub 2016 Mar 1.

13.

Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents.

Dos Santos-Júnior A, Henriques TB, de Mello MP, Della Torre OH, Paes LA, Ferreira-Neto AP, Sewaybricker LE, Fontana TS, Celeri EH, Guerra-Júnior G, Dalgalarrondo P.

Int J Endocrinol. 2016;2016:5872423. doi: 10.1155/2016/5872423. Epub 2016 Jan 6. Erratum in: Int J Endocrinol. 2017;2017:8165368.

14.

Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case-control study.

Hollensted M, Ahluwalia TS, Have CT, Grarup N, Fonvig CE, Nielsen TR, Trier C, Paternoster L, Pedersen O, Holm JC, Sørensen TI, Hansen T.

BMC Med Genet. 2015 Nov 11;16:105. doi: 10.1186/s12881-015-0253-3.

15.

ADIPOQ -11377C>G Polymorphism Increases the Risk of Adipokine Abnormalities and Child Obesity Regardless of Dietary Intake.

Gajewska J, Kuryłowicz A, Ambroszkiewicz J, Mierzejewska E, Chełchowska M, Szamotulska K, Weker H, Puzianowska-Kuźnicka M.

J Pediatr Gastroenterol Nutr. 2016 Jan;62(1):122-9. doi: 10.1097/MPG.0000000000000900.

PMID:
26192702
16.

Genetic and epigenetic associations to obesity-related appetite phenotypes among African-American children.

Gardner KR, Sapienza C, Fisher JO.

Pediatr Obes. 2015 Dec;10(6):476-82. doi: 10.1111/ijpo.12010. Epub 2015 Mar 16.

PMID:
25779370
17.

Seven novel deleterious LEPR mutations found in early-onset obesity: a ΔExon6-8 shared by subjects from Reunion Island, France, suggests a founder effect.

Huvenne H, Le Beyec J, Pépin D, Alili R, Kherchiche PP, Jeannic E, Frelut ML, Lacorte JM, Nicolino M, Viard A, Laville M, Ledoux S, Tounian P, Poitou C, Dubern B, Clément K.

J Clin Endocrinol Metab. 2015 May;100(5):E757-66. doi: 10.1210/jc.2015-1036. Epub 2015 Mar 9.

PMID:
25751111
18.

Peripheral blood mononuclear cell gene expression profile in obese boys who followed a moderate energy-restricted diet: differences between high and low responders at baseline and after the intervention.

Rendo-Urteaga T, García-Calzón S, González-Muniesa P, Milagro FI, Chueca M, Oyarzabal M, Azcona-Sanjulián MC, Martínez JA, Marti A.

Br J Nutr. 2015 Jan 28;113(2):331-42. doi: 10.1017/S0007114514003584. Epub 2014 Dec 4.

PMID:
25471305
19.

A genome-wide association study identifies a LEPR gene as a novel predisposing factor for childhood fasting plasma glucose.

Go MJ, Hwang JY, Jang HB, Heo L, Park TJ, Lee HJ, Park KH, Kang JH, Lee J, Han BG, Song J, Kim BJ.

Genomics. 2014 Dec;104(6 Pt B):594-8. doi: 10.1016/j.ygeno.2014.09.001. Epub 2014 Sep 16. No abstract available.

20.

Association of Gln223 Arg polymorphism of the leptin receptor gene with indicators of energy expenditure in obese children.

Répásy J, Bokor S, Erhardt É, Molnár D.

Nutrition. 2014 Jul-Aug;30(7-8):837-40. doi: 10.1016/j.nut.2014.01.012. Epub 2014 Feb 15.

PMID:
24985001

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