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Items: 1 to 20 of 49

1.

Delivery of Adeno-Associated Viral Vectors in Adult Mammalian Inner Ear Cell Subtypes without Auditory Dysfunction.

Tao Y, Huang M, Shu Y, Ruprecht A, Wang H, Tang Y, Vandenberghe LH, Wang Q, Gao G, Kong WJ, Chen ZY.

Hum Gene Ther. 2017 Nov 12. doi: 10.1089/hum.2017.120. [Epub ahead of print]

PMID:
29130354
2.

Creation of miniature pig model of human Waardenburg syndrome type 2A by ENU mutagenesis.

Hai T, Guo W, Yao J, Cao C, Luo A, Qi M, Wang X, Wang X, Huang J, Zhang Y, Zhang H, Wang D, Shang H, Hong Q, Zhang R, Jia Q, Zheng Q, Qin G, Li Y, Zhang T, Jin W, Chen ZY, Wang H, Zhou Q, Meng A, Wei H, Yang S, Zhao J.

Hum Genet. 2017 Nov 1. doi: 10.1007/s00439-017-1851-2. [Epub ahead of print]

PMID:
29094203
3.

Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear <i>In Vivo</i>.

Shu Y, Tao Y, Li W, Shen J, Wang Z, Chen ZY.

Neural Plast. 2016;2016:9409846. doi: 10.1155/2016/9409846. Epub 2016 Dec 28.

4.

Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration.

Lee SG, Huang M, Obholzer ND, Sun S, Li W, Petrillo M, Dai P, Zhou Y, Cotanche DA, Megason SG, Li H, Chen ZY.

PLoS One. 2016 Jun 28;11(6):e0157768. doi: 10.1371/journal.pone.0157768. eCollection 2016.

5.

Identification of Adeno-Associated Viral Vectors That Target Neonatal and Adult Mammalian Inner Ear Cell Subtypes.

Shu Y, Tao Y, Wang Z, Tang Y, Li H, Dai P, Gao G, Chen ZY.

Hum Gene Ther. 2016 Sep;27(9):687-99. doi: 10.1089/hum.2016.053. Epub 2016 Jun 24.

6.

Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo.

Li M, Tao Y, Shu Y, LaRochelle JR, Steinauer A, Thompson D, Schepartz A, Chen ZY, Liu DR.

J Am Chem Soc. 2015 Nov 11;137(44):14084-93. doi: 10.1021/jacs.5b05694. Epub 2015 Oct 30.

PMID:
26465072
7.

The application of genome editing in studying hearing loss.

Zou B, Mittal R, Grati M, Lu Z, Shu Y, Tao Y, Feng Y, Xie D, Kong W, Yang S, Chen ZY, Liu X.

Hear Res. 2015 Sep;327:102-8. doi: 10.1016/j.heares.2015.04.016. Epub 2015 May 15. Review.

8.

Gene Expression by Mouse Inner Ear Hair Cells during Development.

Scheffer DI, Shen J, Corey DP, Chen ZY.

J Neurosci. 2015 Apr 22;35(16):6366-80. doi: 10.1523/JNEUROSCI.5126-14.2015.

9.

XIRP2, an actin-binding protein essential for inner ear hair-cell stereocilia.

Scheffer DI, Zhang DS, Shen J, Indzhykulian A, Karavitaki KD, Xu YJ, Wang Q, Lin JJ, Chen ZY, Corey DP.

Cell Rep. 2015 Mar 24;10(11):1811-8. doi: 10.1016/j.celrep.2015.02.042. Epub 2015 Mar 12.

10.

Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway.

Li W, Wu J, Yang J, Sun S, Chai R, Chen ZY, Li H.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):166-71. doi: 10.1073/pnas.1415901112. Epub 2014 Dec 22.

11.

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo.

Zuris JA, Thompson DB, Shu Y, Guilinger JP, Bessen JL, Hu JH, Maeder ML, Joung JK, Chen ZY, Liu DR.

Nat Biotechnol. 2015 Jan;33(1):73-80. doi: 10.1038/nbt.3081. Epub 2014 Oct 30.

12.

Disrupting the interaction between retinoblastoma protein and Raf-1 leads to defects in progenitor cell proliferation and survival during early inner ear development.

Li W, Sun S, Chen Y, Yu H, Chen ZY, Li H.

PLoS One. 2013 Dec 31;8(12):e83726. doi: 10.1371/journal.pone.0083726. eCollection 2013.

13.

Hair cell overexpression of Islet1 reduces age-related and noise-induced hearing loss.

Huang M, Kantardzhieva A, Scheffer D, Liberman MC, Chen ZY.

J Neurosci. 2013 Sep 18;33(38):15086-94. doi: 10.1523/JNEUROSCI.1489-13.2013.

14.

Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise.

Yan D, Zhu Y, Walsh T, Xie D, Yuan H, Sirmaci A, Fujikawa T, Wong AC, Loh TL, Du L, Grati M, Vlajkovic SM, Blanton S, Ryan AF, Chen ZY, Thorne PR, Kachar B, Tekin M, Zhao HB, Housley GD, King MC, Liu XZ.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2228-33. doi: 10.1073/pnas.1222285110. Epub 2013 Jan 23.

15.

Sonic hedgehog initiates cochlear hair cell regeneration through downregulation of retinoblastoma protein.

Lu N, Chen Y, Wang Z, Chen G, Lin Q, Chen ZY, Li H.

Biochem Biophys Res Commun. 2013 Jan 11;430(2):700-5. doi: 10.1016/j.bbrc.2012.11.088. Epub 2012 Dec 2.

16.

Analysis of miR-376 RNA cluster members in the mouse inner ear.

Yan D, Xing Y, Ouyang X, Zhu J, Chen ZY, Lang H, Liu XZ.

Int J Exp Pathol. 2012 Dec;93(6):450-7. doi: 10.1111/j.1365-2613.2012.00840.x.

17.

Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss.

Yariz KO, Duman D, Zazo Seco C, Dallman J, Huang M, Peters TA, Sirmaci A, Lu N, Schraders M, Skromne I, Oostrik J, Diaz-Horta O, Young JI, Tokgoz-Yilmaz S, Konukseven O, Shahin H, Hetterschijt L, Kanaan M, Oonk AM, Edwards YJ, Li H, Atalay S, Blanton S, Desmidt AA, Liu XZ, Pennings RJ, Lu Z, Chen ZY, Kremer H, Tekin M.

Am J Hum Genet. 2012 Nov 2;91(5):872-82. doi: 10.1016/j.ajhg.2012.09.011.

18.

Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64.

Cheng J, Zhu Y, He S, Lu Y, Chen J, Han B, Petrillo M, Wrzeszczynski KO, Yang S, Dai P, Zhai S, Han D, Zhang MQ, Li W, Liu X, Li H, Chen ZY, Yuan H.

Am J Hum Genet. 2011 Jul 15;89(1):56-66. doi: 10.1016/j.ajhg.2011.05.027. Epub 2011 Jun 30.

19.

Overlapping and distinct pRb pathways in the mammalian auditory and vestibular organs.

Huang M, Sage C, Tang Y, Lee SG, Petrillo M, Hinds PW, Chen ZY.

Cell Cycle. 2011 Jan 15;10(2):337-51. Epub 2011 Jan 15.

20.

A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss.

Sirmaci A, Erbek S, Price J, Huang M, Duman D, Cengiz FB, Bademci G, Tokgöz-Yilmaz S, Hişmi B, Ozdağ H, Oztürk B, Kulaksizoğlu S, Yildirim E, Kokotas H, Grigoriadou M, Petersen MB, Shahin H, Kanaan M, King MC, Chen ZY, Blanton SH, Liu XZ, Zuchner S, Akar N, Tekin M.

Am J Hum Genet. 2010 May 14;86(5):797-804. doi: 10.1016/j.ajhg.2010.04.004. Epub 2010 May 6.

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