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Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling.

Durak O, Gao F, Kaeser-Woo YJ, Rueda R, Martorell AJ, Nott A, Liu CY, Watson LA, Tsai LH.

Nat Neurosci. 2016 Oct 3. doi: 10.1038/nn.4400.


CHD8 haploinsufficiency results in autistic-like phenotypes in mice.

Katayama Y, Nishiyama M, Shoji H, Ohkawa Y, Kawamura A, Sato T, Suyama M, Takumi T, Miyakawa T, Nakayama KI.

Nature. 2016 Sep 7;537(7622):675-679. doi: 10.1038/nature19357. [Epub ahead of print]


Identification of a rare variant in CHD8 that contributes to schizophrenia and autism spectrum disorder susceptibility.

Kimura H, Wang C, Ishizuka K, Xing J, Takasaki Y, Kushima I, Aleksic B, Uno Y, Okada T, Ikeda M, Mori D, Inada T, Iwata N, Ozaki N.

Schizophr Res. 2016 Aug 29. pii: S0920-9964(16)30373-5. doi: 10.1016/j.schres.2016.08.023. [Epub ahead of print] No abstract available.


CHD8 intragenic deletion associated with autism spectrum disorder.

Stolerman ES, Smith B, Chaubey A, Jones JR.

Eur J Med Genet. 2016 Apr;59(4):189-94. doi: 10.1016/j.ejmg.2016.02.010. Epub 2016 Feb 26.


Novel 14q11.2 microduplication including the CHD8 and SUPT16H genes associated with developmental delay.

Smyk M, Poluha A, Jaszczuk I, Bartnik M, Bernaciak J, Nowakowska B.

Am J Med Genet A. 2016 May;170A(5):1325-9. doi: 10.1002/ajmg.a.37579. Epub 2016 Feb 2.


Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells.

de Dieuleveult M, Yen K, Hmitou I, Depaux A, Boussouar F, Bou Dargham D, Jounier S, Humbertclaude H, Ribierre F, Baulard C, Farrell NP, Park B, Keime C, Carrière L, Berlivet S, Gut M, Gut I, Werner M, Deleuze JF, Olaso R, Aude JC, Chantalat S, Pugh BF, Gérard M.

Nature. 2016 Feb 4;530(7588):113-6. doi: 10.1038/nature16505. Epub 2016 Jan 27.


A de novo frameshift mutation in chromodomain helicase DNA-binding domain 8 (CHD8): A case report and literature review.

Merner N, Forgeot d'Arc B, Bell SC, Maussion G, Peng H, Gauthier J, Crapper L, Hamdan FF, Michaud JL, Mottron L, Rouleau GA, Ernst C.

Am J Med Genet A. 2016 May;170A(5):1225-35. doi: 10.1002/ajmg.a.37566. Epub 2016 Jan 20.


Common BRAF(V600E)-directed pathway mediates widespread epigenetic silencing in colorectal cancer and melanoma.

Fang M, Hutchinson L, Deng A, Green MR.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1250-5. doi: 10.1073/pnas.1525619113. Epub 2016 Jan 19.


Mutations and Modeling of the Chromatin Remodeler CHD8 Define an Emerging Autism Etiology.

Barnard RA, Pomaville MB, O'Roak BJ.

Front Neurosci. 2015 Dec 17;9:477. doi: 10.3389/fnins.2015.00477. eCollection 2015. Review.


Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers.

Pramparo T, Lombardo MV, Campbell K, Barnes CC, Marinero S, Solso S, Young J, Mayo M, Dale A, Ahrens-Barbeau C, Murray SS, Lopez L, Lewis N, Pierce K, Courchesne E.

Mol Syst Biol. 2015 Dec 14;11(12):841. doi: 10.15252/msb.20156108.


NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.

Shen C, Ipsaro JJ, Shi J, Milazzo JP, Wang E, Roe JS, Suzuki Y, Pappin DJ, Joshua-Tor L, Vakoc CR.

Mol Cell. 2015 Dec 17;60(6):847-59. doi: 10.1016/j.molcel.2015.10.033. Epub 2015 Nov 25.


The Chromatin Regulator CHD8 Is a Context-Dependent Mediator of Cell Survival in Murine Hematopoietic Malignancies.

Shingleton JR, Hemann MT.

PLoS One. 2015 Nov 20;10(11):e0143275. doi: 10.1371/journal.pone.0143275. eCollection 2015.


First glimpses of the neurobiology of autism spectrum disorder.

Sanders SJ.

Curr Opin Genet Dev. 2015 Aug;33:80-92. doi: 10.1016/j.gde.2015.10.002. Epub 2015 Nov 9. Review.


CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment.

Wang P, Lin M, Pedrosa E, Hrabovsky A, Zhang Z, Guo W, Lachman HM, Zheng D.

Mol Autism. 2015 Oct 19;6:55. doi: 10.1186/s13229-015-0048-6. eCollection 2015.


A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients.

Pongor L, Kormos M, Hatzis C, Pusztai L, Szabó A, Győrffy B.

Genome Med. 2015 Oct 16;7:104. doi: 10.1186/s13073-015-0228-1.


Investigation of genes important in neurodevelopment disorders in adult human brain.

Maussion G, Diallo AB, Gigek CO, Chen ES, Crapper L, Théroux JF, Chen GG, Vasuta C, Ernst C.

Hum Genet. 2015 Oct;134(10):1037-53. doi: 10.1007/s00439-015-1584-z. Epub 2015 Jul 21.


The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes.

Wilkinson B, Grepo N, Thompson BL, Kim J, Wang K, Evgrafov OV, Lu W, Knowles JA, Campbell DB.

Transl Psychiatry. 2015 May 19;5:e568. doi: 10.1038/tp.2015.62.


Excess of rare, inherited truncating mutations in autism.

Krumm N, Turner TN, Baker C, Vives L, Mohajeri K, Witherspoon K, Raja A, Coe BP, Stessman HA, He ZX, Leal SM, Bernier R, Eichler EE.

Nat Genet. 2015 Jun;47(6):582-8. doi: 10.1038/ng.3303. Epub 2015 May 11.


The chromatin Remodeler CHD8 is required for activation of progesterone receptor-dependent enhancers.

Ceballos-Chávez M, Subtil-Rodríguez A, Giannopoulou EG, Soronellas D, Vázquez-Chávez E, Vicent GP, Elemento O, Beato M, Reyes JC.

PLoS Genet. 2015 Apr 20;11(4):e1005174. doi: 10.1371/journal.pgen.1005174. eCollection 2015 Apr.


The promise of multi-omics and clinical data integration to identify and target personalized healthcare approaches in autism spectrum disorders.

Higdon R, Earl RK, Stanberry L, Hudac CM, Montague E, Stewart E, Janko I, Choiniere J, Broomall W, Kolker N, Bernier RA, Kolker E.

OMICS. 2015 Apr;19(4):197-208. doi: 10.1089/omi.2015.0020. Review.

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