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Items: 1 to 20 of 43

1.

Multiple Layers of CDK5R1 Regulation in Alzheimer's Disease Implicate Long Non-Coding RNAs.

Spreafico M, Grillo B, Rusconi F, Battaglioli E, Venturin M.

Int J Mol Sci. 2018 Jul 11;19(7). pii: E2022. doi: 10.3390/ijms19072022.

2.

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia.

Seo J, Kritskiy O, Watson LA, Barker SJ, Dey D, Raja WK, Lin YT, Ko T, Cho S, Penney J, Silva MC, Sheridan SD, Lucente D, Gusella JF, Dickerson BC, Haggarty SJ, Tsai LH.

J Neurosci. 2017 Oct 11;37(41):9917-9924. doi: 10.1523/JNEUROSCI.0621-17.2017. Epub 2017 Sep 14.

3.

Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease.

Chang WS, Wang YH, Zhu XT, Wu CJ.

Med Sci Monit. 2017 Jun 4;23:2721-2731.

4.

TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice.

Shukla V, Seo J, Binukumar BK, Amin ND, Reddy P, Grant P, Kuntz S, Kesavapany S, Steiner J, Mishra SK, Tsai LH, Pant HC.

J Alzheimers Dis. 2017;56(1):335-349. doi: 10.3233/JAD-160916.

PMID:
28085018
5.
6.

Profiling of p5, a 24 Amino Acid Inhibitory Peptide Derived from the CDK5 Activator, p35 CDKR1 Against 70 Protein Kinases.

Binukumar BK, Pelech SL, Sutter C, Shukla V, Amin ND, Grant P, Bhaskar M, Skuntz S, Steiner J, Pant HC.

J Alzheimers Dis. 2016 Sep 6;54(2):525-33. doi: 10.3233/JAD-160458.

PMID:
27567857
7.

The miR-15/107 Family of microRNA Genes Regulates CDK5R1/p35 with Implications for Alzheimer's Disease Pathogenesis.

Moncini S, Lunghi M, Valmadre A, Grasso M, Del Vescovo V, Riva P, Denti MA, Venturin M.

Mol Neurobiol. 2017 Aug;54(6):4329-4342. doi: 10.1007/s12035-016-0002-4. Epub 2016 Jun 24.

8.

PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice.

Toba J, Nikkuni M, Ishizeki M, Yoshii A, Watamura N, Inoue T, Ohshima T.

Biochem Biophys Res Commun. 2016 May 13;473(4):1039-1044. doi: 10.1016/j.bbrc.2016.04.012. Epub 2016 Apr 5.

PMID:
27059136
9.

The mechanisms regulating cyclin-dependent kinase 5 in hippocampus during systemic inflammatory response: The effect on inflammatory gene expression.

Czapski GA, Gąssowska M, Wilkaniec A, Chalimoniuk M, Strosznajder JB, Adamczyk A.

Neurochem Int. 2016 Feb;93:103-12. doi: 10.1016/j.neuint.2016.01.005. Epub 2016 Jan 21.

PMID:
26806339
10.

Reduction of glutamate-induced excitotoxicity in murine primary neurons involving calpain inhibition.

Gold M, Koczulla AR, Mengel D, Koepke J, Dodel R, Dontcheva G, Habib P, Bach JP.

J Neurol Sci. 2015 Dec 15;359(1-2):356-62. doi: 10.1016/j.jns.2015.11.016. Epub 2015 Nov 11.

PMID:
26671142
11.

Activation of Cdk5/p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves microRNA-195 down-regulation.

Sun LH, Ban T, Liu CD, Chen QX, Wang X, Yan ML, Hu XL, Su XL, Bao YN, Sun LL, Zhao LJ, Pei SC, Jiang XM, Zong DK, Ai J.

J Neurochem. 2015 Sep;134(6):1139-51. doi: 10.1111/jnc.13212.

12.

Cdk5 is a New Rapid Synaptic Homeostasis Regulator Capable of Initiating the Early Alzheimer-Like Pathology.

Sheng Y, Zhang L, Su SC, Tsai LH, Julius Zhu J.

Cereb Cortex. 2016 Jul;26(7):2937-51. doi: 10.1093/cercor/bhv032. Epub 2015 Jun 17.

13.

The inhibition of Cdk5 activity after hypoxia/ischemia injury reduces infarct size and promotes functional recovery in neonatal rats.

Tan X, Chen Y, Li J, Li X, Miao Z, Xin N, Zhu J, Ge W, Feng Y, Xu X.

Neuroscience. 2015 Apr 2;290:552-60. doi: 10.1016/j.neuroscience.2015.01.054. Epub 2015 Feb 7.

PMID:
25665755
14.

CDK5 activator protein p25 preferentially binds and activates GSK3β.

Chow HM, Guo D, Zhou JC, Zhang GY, Li HF, Herrup K, Zhang J.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4887-95. doi: 10.1073/pnas.1402627111. Epub 2014 Oct 20. Erratum in: Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):E3313.

15.

Infantile postnatal exposure to lead (Pb) enhances tau expression in the cerebral cortex of aged mice: relevance to AD.

Bihaqi SW, Bahmani A, Adem A, Zawia NH.

Neurotoxicology. 2014 Sep;44:114-20. doi: 10.1016/j.neuro.2014.06.008. Epub 2014 Jun 20.

16.

Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment.

Seo J, Giusti-Rodríguez P, Zhou Y, Rudenko A, Cho S, Ota KT, Park C, Patzke H, Madabhushi R, Pan L, Mungenast AE, Guan JS, Delalle I, Tsai LH.

Cell. 2014 Apr 10;157(2):486-498. doi: 10.1016/j.cell.2014.01.065.

17.

Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice.

Currais A, Prior M, Dargusch R, Armando A, Ehren J, Schubert D, Quehenberger O, Maher P.

Aging Cell. 2014 Apr;13(2):379-90. doi: 10.1111/acel.12185. Epub 2013 Dec 17.

18.

TFP5, a peptide derived from p35, a Cdk5 neuronal activator, rescues cortical neurons from glucose toxicity.

Binukumar BK, Zheng YL, Shukla V, Amin ND, Grant P, Pant HC.

J Alzheimers Dis. 2014;39(4):899-909. doi: 10.3233/JAD-131784.

19.

p35 deficiency accelerates HMGB-1-mediated neuronal death in the early stages of an Alzheimer's disease mouse model.

Jang A, Liew H, Kim YM, Choi H, Kim S, Lee SH, Ohshima T, Mikoshiba K, Suh YH.

Curr Alzheimer Res. 2013 Oct;10(8):829-43.

PMID:
23905994
20.

Hypoxia increases Aβ-induced tau phosphorylation by calpain and promotes behavioral consequences in AD transgenic mice.

Gao L, Tian S, Gao H, Xu Y.

J Mol Neurosci. 2013 Sep;51(1):138-47. doi: 10.1007/s12031-013-9966-y. Epub 2013 Jan 24.

PMID:
23345083

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