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Items: 1 to 20 of 547


Mechanism involved in insulin resistance via accumulation of β-amyloid and neurofibrillary tangles: link between type 2 diabetes and Alzheimer's disease.

Rad SK, Arya A, Karimian H, Madhavan P, Rizwan F, Koshy S, Prabhu G.

Drug Des Devel Ther. 2018 Nov 22;12:3999-4021. doi: 10.2147/DDDT.S173970. eCollection 2018. Review.


Amyloid-ß promotes neurotoxicity by Cdk5-induced p53 stabilization.

Lapresa R, Agulla J, Sánchez-Morán I, Zamarreño R, Prieto E, Bolaños JP, Almeida A.

Neuropharmacology. 2018 Nov 16;146:19-27. doi: 10.1016/j.neuropharm.2018.11.019. [Epub ahead of print]


Novel Protein Kinase Inhibitors Related to Tau Pathology Modulate Tau Protein-Self Interaction Using a Luciferase Complementation Assay.

Holzer M, Schade N, Opitz A, Hilbrich I, Stieler J, Vogel T, Neukel V, Oberstadt M, Totzke F, Schächtele C, Sippl W, Hilgeroth A.

Molecules. 2018 Sep 12;23(9). pii: E2335. doi: 10.3390/molecules23092335.


Peroxisome proliferator-activated receptor alpha accelerates neuronal differentiation and this might involve the mitogen-activated protein kinase pathway.

Lin C, Chen PY, Chan HC, Huang YP, Chang NW.

Int J Dev Neurosci. 2018 Dec;71:46-51. doi: 10.1016/j.ijdevneu.2018.08.006. Epub 2018 Aug 26.


Integrative computational evaluation of genetic markers for Alzheimer's disease.

Li Z, Xiong Z, Manor LC, Cao H, Li T.

Saudi J Biol Sci. 2018 Jul;25(5):996-1002. doi: 10.1016/j.sjbs.2018.05.019. Epub 2018 May 18.


The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro.

Liu P, Chen X, Zhou H, Wang L, Zhang Z, Ren X, Zhu F, Guo Y, Huang X, Liu J, Spencer PS, Yang X.

Oxid Med Cell Longev. 2018 Jul 2;2018:2025914. doi: 10.1155/2018/2025914. eCollection 2018.


β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals.

Wu HY, Kuo PC, Wang YT, Lin HT, Roe AD, Wang BY, Han CL, Hyman BT, Chen YJ, Tai HC.

J Neuropathol Exp Neurol. 2018 Sep 1;77(9):814-826. doi: 10.1093/jnen/nly059.


Molecular properties underlying regional vulnerability to Alzheimer's disease pathology.

Grothe MJ, Sepulcre J, Gonzalez-Escamilla G, Jelistratova I, Schöll M, Hansson O, Teipel SJ; Alzheimer’s Disease Neuroimaging Initiative.

Brain. 2018 Sep 1;141(9):2755-2771. doi: 10.1093/brain/awy189.


Multiple Layers of CDK5R1 Regulation in Alzheimer's Disease Implicate Long Non-Coding RNAs.

Spreafico M, Grillo B, Rusconi F, Battaglioli E, Venturin M.

Int J Mol Sci. 2018 Jul 11;19(7). pii: E2022. doi: 10.3390/ijms19072022.


Multifaceted Regulation of ALDH1A1 by Cdk5 in Alzheimer's Disease Pathogenesis.

Nikhil K, Viccaro K, Shah K.

Mol Neurobiol. 2018 Jun 8. doi: 10.1007/s12035-018-1114-9. [Epub ahead of print]


The Transcriptional Regulatory Properties of Amyloid Beta 1-42 may Include Regulation of Genes Related to Neurodegeneration.

Gezen-Ak D, Atasoy İL, Candaş E, Alaylıoğlu M, Dursun E.

Neuromolecular Med. 2018 Sep;20(3):363-375. doi: 10.1007/s12017-018-8498-6. Epub 2018 Jun 12.


Modulating Protein Phosphatase 2A Rescues Disease Phenotype in Neurodegenerative Tauopathies.

McKenzie-Nickson S, Chan J, Perez K, Hung LW, Cheng L, Sedjahtera A, Gunawan L, Adlard PA, Hayne DJ, McInnes LE, Donnelly PS, Finkelstein DI, Hill AF, Barnham KJ.

ACS Chem Neurosci. 2018 Nov 21;9(11):2731-2740. doi: 10.1021/acschemneuro.8b00161. Epub 2018 Jul 3.


Cdk5 Inhibitory Peptide Prevents Loss of Dopaminergic Neurons and Alleviates Behavioral Changes in an MPTP Induced Parkinson's Disease Mouse Model.

He R, Huang W, Huang Y, Xu M, Song P, Huang Y, Xie H, Hu Y.

Front Aging Neurosci. 2018 Jun 1;10:162. doi: 10.3389/fnagi.2018.00162. eCollection 2018.


Learning Impairments, Memory Deficits, and Neuropathology in Aged Tau Transgenic Mice Are Dependent on Leukotrienes Biosynthesis: Role of the cdk5 Kinase Pathway.

Giannopoulos PF, Chiu J, Praticò D.

Mol Neurobiol. 2018 Jun 7. doi: 10.1007/s12035-018-1124-7. [Epub ahead of print]


Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APPswe/PS1dE9 Mice and Their Wild Type Littermates.

Zhang F, Zhong R, Qi H, Li S, Cheng C, Liu X, Liu Y, Le W.

Front Neurosci. 2018 May 9;12:314. doi: 10.3389/fnins.2018.00314. eCollection 2018.


Acylphloroglucinols as kinase inhibitors from Sargassum nigrifoloides.

Jiang CS, Wang YY, Song JT, Yu JH.

J Asian Nat Prod Res. 2018 May 28:1-8. doi: 10.1080/10286020.2018.1463996. [Epub ahead of print]


Proteome and behavioral alterations in phosphorylation-deficient mutant Collapsin Response Mediator Protein2 knock-in mice.

Nakamura H, Takahashi-Jitsuki A, Makihara H, Asano T, Kimura Y, Nakabayashi J, Yamashita N, Kawamoto Y, Nakamura F, Ohshima T, Hirano H, Tanaka F, Goshima Y.

Neurochem Int. 2018 Oct;119:207-217. doi: 10.1016/j.neuint.2018.04.009. Epub 2018 May 11.


Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.

Di Meco A, Li JG, Barrero C, Merali S, Praticò D.

Mol Psychiatry. 2018 May 4. doi: 10.1038/s41380-018-0062-0. [Epub ahead of print]


Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice.

Giannopoulos PF, Chiu J, Praticò D.

Aging Cell. 2018 Jun;17(3):e12759. doi: 10.1111/acel.12759. Epub 2018 Apr 1.

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