Format
Sort by
Items per page

Send to

Choose Destination

Best matches for cdc2 alzheimer's:

Search results

Items: 1 to 20 of 92

1.

Computer-Aided Drug Design Applied to Marine Drug Discovery: Meridianins as Alzheimer's Disease Therapeutic Agents.

Llorach-Pares L, Nonell-Canals A, Sanchez-Martinez M, Avila C.

Mar Drugs. 2017 Nov 27;15(12). pii: E366. doi: 10.3390/md15120366.

2.

Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases.

Loaëc N, Attanasio E, Villiers B, Durieu E, Tahtouh T, Cam M, Davis RA, Alencar A, Roué M, Bourguet-Kondracki ML, Proksch P, Limanton E, Guiheneuf S, Carreaux F, Bazureau JP, Klautau M, Meijer L.

Mar Drugs. 2017 Oct 17;15(10). pii: E316. doi: 10.3390/md15100316. Review.

3.

Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors.

Labrière C, Lozach O, Blairvacq M, Meijer L, Guillou C.

Eur J Med Chem. 2016 Nov 29;124:920-934. doi: 10.1016/j.ejmech.2016.08.069. Epub 2016 Aug 31.

PMID:
27676471
4.

Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice.

Naert G, Ferré V, Meunier J, Keller E, Malmström S, Givalois L, Carreaux F, Bazureau JP, Maurice T.

Eur Neuropsychopharmacol. 2015 Nov;25(11):2170-82. doi: 10.1016/j.euroneuro.2015.03.018. Epub 2015 Apr 10.

PMID:
26381812
5.

Regulation of Bcl-xL-ATP Synthase Interaction by Mitochondrial Cyclin B1-Cyclin-Dependent Kinase-1 Determines Neuronal Survival.

Veas-Pérez de Tudela M, Delgado-Esteban M, Maestre C, Bobo-Jiménez V, Jiménez-Blasco D, Vecino R, Bolaños JP, Almeida A.

J Neurosci. 2015 Jun 24;35(25):9287-301. doi: 10.1523/JNEUROSCI.4712-14.2015.

6.

Effects of suppressed autophagy on mitochondrial dynamics and cell cycle of N2a cells.

Gui MC, Chen B, Yu SS, Bu BT.

J Huazhong Univ Sci Technolog Med Sci. 2014 Apr;34(2):157-160. doi: 10.1007/s11596-014-1250-z. Epub 2014 Apr 8.

PMID:
24710924
7.

Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease.

Talwar P, Silla Y, Grover S, Gupta M, Agarwal R, Kushwaha S, Kukreti R.

BMC Genomics. 2014 Mar 15;15:199. doi: 10.1186/1471-2164-15-199.

8.

Human CDC2-like kinase 1 (CLK1): a novel target for Alzheimer's disease.

Jain P, Karthikeyan C, Moorthy NS, Waiker DK, Jain AK, Trivedi P.

Curr Drug Targets. 2014 May;15(5):539-50. Review.

PMID:
24568585
10.

Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines.

Burgy G, Tahtouh T, Durieu E, Foll-Josselin B, Limanton E, Meijer L, Carreaux F, Bazureau JP.

Eur J Med Chem. 2013 Apr;62:728-37. doi: 10.1016/j.ejmech.2013.01.035. Epub 2013 Feb 6.

PMID:
23454515
11.

Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases.

Tell V, Holzer M, Herrmann L, Mahmoud KA, Schächtele C, Totzke F, Hilgeroth A.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6914-8. doi: 10.1016/j.bmcl.2012.09.006. Epub 2012 Sep 13.

PMID:
23039927
12.

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

Tahtouh T, Elkins JM, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, Cochet C, Schmid RS, Lo DC, Delhommel F, Oberholzer AE, Pearl LH, Carreaux F, Bazureau JP, Knapp S, Meijer L.

J Med Chem. 2012 Nov 8;55(21):9312-30. doi: 10.1021/jm301034u. Epub 2012 Oct 8.

PMID:
22998443
13.

STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease.

van Abel D, Abdulhamid O, Scheper W, van Dijk M, Oudejans CB.

Neurosci Lett. 2012 Oct 24;528(2):104-9. doi: 10.1016/j.neulet.2012.09.017. Epub 2012 Sep 17.

PMID:
22995177
14.

Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death.

Chang KH, Vincent F, Shah K.

J Cell Sci. 2012 Nov 1;125(Pt 21):5124-37. doi: 10.1242/jcs.108183. Epub 2012 Aug 16.

15.

Mitosis-specific phosphorylation of amyloid precursor protein at threonine 668 leads to its altered processing and association with centrosomes.

Judge M, Hornbeck L, Potter H, Padmanabhan J.

Mol Neurodegener. 2011 Nov 23;6:80. doi: 10.1186/1750-1326-6-80.

16.

Genetic variation in the tau kinases pathway may modify the risk and age at onset of Alzheimer's disease.

Vázquez-Higuera JL, Mateo I, Sánchez-Juan P, Rodríguez-Rodríguez E, Pozueta A, Calero M, Dobato JL, Frank-García A, Valdivieso F, Berciano J, Bullido MJ, Combarros O.

J Alzheimers Dis. 2011;27(2):291-7. doi: 10.3233/JAD-2011-110794.

PMID:
21811019
17.

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP.

J Med Chem. 2011 Jun 23;54(12):4172-86. doi: 10.1021/jm200274d. Epub 2011 May 26.

PMID:
21615147
18.

Quantitative reverse-transcription polymerase chain reaction analysis of Alzheimer's-associated genes in mouse scrapie.

Medina S, Hatherall A, Parchaliuk D, Robertson C, Booth SA.

J Toxicol Environ Health A. 2009;72(17-18):1075-82. doi: 10.1080/15287390903084561.

PMID:
19697242
19.

Mitotic epitopes are incorporated into age-dependent neurofibrillary tangles in Niemann-Pick disease type C.

Zhang M, Wang X, Jiang F, Wang W, Vincent I, Bu B.

Brain Pathol. 2010 Mar;20(2):367-77. doi: 10.1111/j.1750-3639.2009.00286.x. Epub 2009 May 20.

PMID:
19476463
20.

Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease.

Sun KH, de Pablo Y, Vincent F, Johnson EO, Chavers AK, Shah K.

Mol Biol Cell. 2008 Jul;19(7):3052-69. doi: 10.1091/mbc.E07-11-1106. Epub 2008 May 14.

Supplemental Content

Loading ...
Support Center