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Items: 1 to 20 of 162


T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse.

Dong TX, Othy S, Jairaman A, Skupsky J, Zavala A, Parker I, Dynes JL, Cahalan MD.

Elife. 2017 Dec 14;6. pii: e32417. doi: 10.7554/eLife.32417.


Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility.

Dong TX, Othy S, Greenberg ML, Jairaman A, Akunwafo C, Leverrier S, Yu Y, Parker I, Dynes JL, Cahalan MD.

Elife. 2017 Dec 14;6. pii: e27827. doi: 10.7554/eLife.27827.


iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.

Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R, Gylys KH, Cahalan MD, Cummings BJ, Antel JP, Mortazavi A, Carson MJ, Poon WW, Blurton-Jones M.

Neuron. 2017 Apr 19;94(2):278-293.e9. doi: 10.1016/j.neuron.2017.03.042.


Genetically targeted single-channel optical recording reveals multiple Orai1 gating states and oscillations in calcium influx.

Dynes JL, Amcheslavsky A, Cahalan MD.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):440-5. doi: 10.1073/pnas.1523410113. Epub 2015 Dec 28.


Nanoscale patterning of STIM1 and Orai1 during store-operated Ca2+ entry.

Perni S, Dynes JL, Yeromin AV, Cahalan MD, Franzini-Armstrong C.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5533-42. doi: 10.1073/pnas.1515606112. Epub 2015 Sep 8.


Two-photon imaging of cellular dynamics in the mouse spinal cord.

Weinger JG, Greenberg ML, Matheu MP, Parker I, Walsh CM, Lane TE, Cahalan MD.

J Vis Exp. 2015 Feb 22;(96). doi: 10.3791/52580.


Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming.

Matheu MP, Othy S, Greenberg ML, Dong TX, Schuijs M, Deswarte K, Hammad H, Lambrecht BN, Parker I, Cahalan MD.

Nat Commun. 2015 Feb 5;6:6219. doi: 10.1038/ncomms7219.


Molecular biophysics of Orai store-operated Ca2+ channels.

Amcheslavsky A, Wood ML, Yeromin AV, Parker I, Freites JA, Tobias DJ, Cahalan MD.

Biophys J. 2015 Jan 20;108(2):237-46. doi: 10.1016/j.bpj.2014.11.3473. Review.


Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies.

Marro BS, Blanc CA, Loring JF, Cahalan MD, Lane TE.

Expert Rev Neurother. 2014 Oct;14(10):1169-79. doi: 10.1586/14737175.2014.955854. Review.


Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis.

Greenberg ML, Weinger JG, Matheu MP, Carbajal KS, Parker I, Macklin WB, Lane TE, Cahalan MD.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2349-55. doi: 10.1073/pnas.1406658111. Epub 2014 May 19.


State-dependent block of Orai3 TM1 and TM3 cysteine mutants: insights into 2-APB activation.

Amcheslavsky A, Safrina O, Cahalan MD.

J Gen Physiol. 2014 May;143(5):621-31. doi: 10.1085/jgp.201411171. Epub 2014 Apr 14.


Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101.

Amcheslavsky A, Safrina O, Cahalan MD.

J Gen Physiol. 2013 Oct;142(4):405-12. doi: 10.1085/jgp.201311030.


Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy.

Matheu MP, Teijaro JR, Walsh KB, Greenberg ML, Marsolais D, Parker I, Rosen H, Oldstone MB, Cahalan MD.

PLoS One. 2013;8(3):e58033. doi: 10.1371/journal.pone.0058033. Epub 2013 Mar 22.


Orai1 function is essential for T cell homing to lymph nodes.

Greenberg ML, Yu Y, Leverrier S, Zhang SL, Parker I, Cahalan MD.

J Immunol. 2013 Apr 1;190(7):3197-206. doi: 10.4049/jimmunol.1202212. Epub 2013 Mar 1.


A decade of imaging cellular motility and interaction dynamics in the immune system.

Germain RN, Robey EA, Cahalan MD.

Science. 2012 Jun 29;336(6089):1676-81. doi: 10.1126/science.1221063. Review.


Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance.

Matheu MP, Su Y, Greenberg ML, Blanc CA, Parker I, Scott DW, Cahalan MD.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1258-66. doi: 10.1073/pnas.1205150109. Epub 2012 Apr 17.


CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation.

Khadra N, Bresson-Bepoldin L, Penna A, Chaigne-Delalande B, Ségui B, Levade T, Vacher AM, Reiffers J, Ducret T, Moreau JF, Cahalan MD, Vacher P, Legembre P.

Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19072-7. doi: 10.1073/pnas.1116946108. Epub 2011 Nov 7.


Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states.

Demuro A, Penna A, Safrina O, Yeromin AV, Amcheslavsky A, Cahalan MD, Parker I.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17832-7. doi: 10.1073/pnas.1114814108. Epub 2011 Oct 10.


Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.

Zhang SL, Yeromin AV, Hu J, Amcheslavsky A, Zheng H, Cahalan MD.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17838-43. doi: 10.1073/pnas.1114821108. Epub 2011 Oct 10.


Analysis of transient migration behavior of natural killer cells imaged in situ and in vitro.

Khorshidi MA, Vanherberghen B, Kowalewski JM, Garrod KR, Lindström S, Andersson-Svahn H, Brismar H, Cahalan MD, Önfelt B.

Integr Biol (Camb). 2011 Jul;3(7):770-8. doi: 10.1039/c1ib00007a. Epub 2011 Jun 20.


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