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Items: 1 to 20 of 45


Arrhythmia dynamics in computational models of the atria following virtual ablation of re-entrant drivers.

Hakim JB, Murphy MJ, Trayanova NA, Boyle PM.

Europace. 2018 Nov 1;20(suppl_3):iii45-iii54. doi: 10.1093/europace/euy234.


The Fibrotic Substrate in Persistent Atrial Fibrillation Patients: Comparison Between Predictions From Computational Modeling and Measurements From Focal Impulse and Rotor Mapping.

Boyle PM, Hakim JB, Zahid S, Franceschi WH, Murphy MJ, Prakosa A, Aronis KN, Zghaib T, Balouch M, Ipek EG, Chrispin J, Berger RD, Ashikaga H, Marine JE, Calkins H, Nazarian S, Spragg DD, Trayanova NA.

Front Physiol. 2018 Aug 29;9:1151. doi: 10.3389/fphys.2018.01151. eCollection 2018.


Cardiac Optogenetics: 2018.

Boyle PM, Karathanos TV, Trayanova NA.

JACC Clin Electrophysiol. 2018 Feb;4(2):155-167. doi: 10.1016/j.jacep.2017.12.006. Epub 2018 Feb 1. Review.


Comparing Reentrant Drivers Predicted by Image-Based Computational Modeling and Mapped by Electrocardiographic Imaging in Persistent Atrial Fibrillation.

Boyle PM, Hakim JB, Zahid S, Franceschi WH, Murphy MJ, Vigmond EJ, Dubois R, Haïssaguerre M, Hocini M, Jaïs P, Trayanova NA, Cochet H.

Front Physiol. 2018 Apr 19;9:414. doi: 10.3389/fphys.2018.00414. eCollection 2018.


Personalized Imaging and Modeling Strategies for Arrhythmia Prevention and Therapy.

Trayanova NA, Boyle PM, Nikolov PP.

Curr Opin Biomed Eng. 2018 Mar;5:21-28. doi: 10.1016/j.cobme.2017.11.007.


Relationship Between Fibrosis Detected on Late Gadolinium-Enhanced Cardiac Magnetic Resonance and Re-Entrant Activity Assessed With Electrocardiographic Imaging in Human Persistent Atrial Fibrillation.

Cochet H, Dubois R, Yamashita S, Al Jefairi N, Berte B, Sellal JM, Hooks D, Frontera A, Amraoui S, Zemoura A, Denis A, Derval N, Sacher F, Corneloup O, Latrabe V, Clément-Guinaudeau S, Relan J, Zahid S, Boyle PM, Trayanova NA, Bernus O, Montaudon M, Laurent F, Hocini M, Haïssaguerre M, Jaïs P.

JACC Clin Electrophysiol. 2018 Jan;4(1):17-29. doi: 10.1016/j.jacep.2017.07.019. Epub 2017 Nov 6.


Termination of re-entrant atrial tachycardia via optogenetic stimulation with optimized spatial targeting: insights from computational models.

Boyle PM, Murphy MJ, Karathanos TV, Zahid S, Blake RC 3rd, Trayanova NA.

J Physiol. 2018 Jan 15;596(2):181-196. doi: 10.1113/JP275264. Epub 2017 Dec 28.


Sensitivity of reentrant driver localization to electrophysiological parameter variability in image-based computational models of persistent atrial fibrillation sustained by a fibrotic substrate.

Deng D, Murphy MJ, Hakim JB, Franceschi WH, Zahid S, Pashakhanloo F, Trayanova NA, Boyle PM.

Chaos. 2017 Sep;27(9):093932. doi: 10.1063/1.5003340.


Using personalized computer models to custom-tailor ablation procedures for atrial fibrillation patients: are we there yet?

Boyle PM, Zahid S, Trayanova NA.

Expert Rev Cardiovasc Ther. 2017 May;15(5):339-341. doi: 10.1080/14779072.2017.1317593. Epub 2017 Apr 17. No abstract available.


Modelling methodology of atrial fibrosis affects rotor dynamics and electrograms.

Roney CH, Bayer JD, Zahid S, Meo M, Boyle PM, Trayanova NA, Haïssaguerre M, Dubois R, Cochet H, Vigmond EJ.

Europace. 2016 Dec;18(suppl 4):iv146-iv155. doi: 10.1093/europace/euw365.


Towards personalized computational modelling of the fibrotic substrate for atrial arrhythmia.

Boyle PM, Zahid S, Trayanova NA.

Europace. 2016 Dec;18(suppl 4):iv136-iv145. doi: 10.1093/europace/euw358. Review.


Light-based Approaches to Cardiac Arrhythmia Research: From Basic Science to Translational Applications.

Karathanos TV, Boyle PM, Trayanova NA.

Clin Med Insights Cardiol. 2016 Nov 2;10(Suppl 1):47-60. eCollection 2016. Review.


Early somatic mosaicism is a rare cause of long-QT syndrome.

Priest JR, Gawad C, Kahlig KM, Yu JK, O'Hara T, Boyle PM, Rajamani S, Clark MJ, Garcia ST, Ceresnak S, Harris J, Boyle S, Dewey FE, Malloy-Walton L, Dunn K, Grove M, Perez MV, Neff NF, Chen R, Maeda K, Dubin A, Belardinelli L, West J, Antolik C, Macaya D, Quertermous T, Trayanova NA, Quake SR, Ashley EA.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11555-11560. Epub 2016 Sep 28.


Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations.

Bruegmann T, Boyle PM, Vogt CC, Karathanos TV, Arevalo HJ, Fleischmann BK, Trayanova NA, Sasse P.

J Clin Invest. 2016 Oct 3;126(10):3894-3904. doi: 10.1172/JCI88950. Epub 2016 Sep 12.


Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.

Arevalo HJ, Boyle PM, Trayanova NA.

Prog Biophys Mol Biol. 2016 Jul;121(2):185-94. doi: 10.1016/j.pbiomolbio.2016.06.004. Epub 2016 Jun 19. Review.


Feasibility of using patient-specific models and the "minimum cut" algorithm to predict optimal ablation targets for left atrial flutter.

Zahid S, Whyte KN, Schwarz EL, Blake RC 3rd, Boyle PM, Chrispin J, Prakosa A, Ipek EG, Pashakhanloo F, Halperin HR, Calkins H, Berger RD, Nazarian S, Trayanova NA.

Heart Rhythm. 2016 Aug;13(8):1687-98. doi: 10.1016/j.hrthm.2016.04.009. Epub 2016 Apr 19.


Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern.

Zahid S, Cochet H, Boyle PM, Schwarz EL, Whyte KN, Vigmond EJ, Dubois R, Hocini M, Haïssaguerre M, Jaïs P, Trayanova NA.

Cardiovasc Res. 2016 Jun 1;110(3):443-54. doi: 10.1093/cvr/cvw073. Epub 2016 Apr 7.


Opsin spectral sensitivity determines the effectiveness of optogenetic termination of ventricular fibrillation in the human heart: a simulation study.

Karathanos TV, Bayer JD, Wang D, Boyle PM, Trayanova NA.

J Physiol. 2016 Dec 1;594(23):6879-6891. doi: 10.1113/JP271739. Epub 2016 Apr 24.


Optogenetics-enabled assessment of viral gene and cell therapy for restoration of cardiac excitability.

Ambrosi CM, Boyle PM, Chen K, Trayanova NA, Entcheva E.

Sci Rep. 2015 Dec 1;5:17350. doi: 10.1038/srep17350.


Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations.

Boyle PM, Karathanos TV, Entcheva E, Trayanova NA.

Comput Biol Med. 2015 Oct 1;65:200-8. doi: 10.1016/j.compbiomed.2015.04.036. Epub 2015 May 7. Review. Erratum in: Comput Biol Med. 2015 Dec 1;67:184.

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