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Items: 1 to 20 of 143

1.

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail JA, Mitasev B, Moss EL, Sayes M, Van Gessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusovsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler EA, Wirth DF, Scherer CA, Schreiber SL.

Nature. 2016 Oct 20;538(7625):344-349. doi: 10.1038/nature19804. Epub 2016 Sep 7.

2.

High-Throughput Platform for Identifying Molecular Factors Involved in Phenotypic Stabilization of Primary Human Hepatocytes In Vitro.

Shan J, Logan DJ, Root DE, Carpenter AE, Bhatia SN.

J Biomol Screen. 2016 Oct;21(9):897-911. doi: 10.1177/1087057116660277. Epub 2016 Aug 4.

PMID:
27650791
3.

Magnetically Actuated Protease Sensors for in Vivo Tumor Profiling.

Schuerle S, Dudani JS, Christiansen MG, Anikeeva P, Bhatia SN.

Nano Lett. 2016 Oct 12;16(10):6303-6310. Epub 2016 Sep 13.

PMID:
27622711
4.

Host AMPK Is a Modulator of Plasmodium Liver Infection.

Ruivo MT, Vera IM, Sales-Dias J, Meireles P, Gural N, Bhatia SN, Mota MM, Mancio-Silva L.

Cell Rep. 2016 Sep 6;16(10):2539-45. doi: 10.1016/j.celrep.2016.08.001. Epub 2016 Aug 25.

5.

Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors.

Jain PK, Ramanan V, Schepers AG, Dalvie NS, Panda A, Fleming HE, Bhatia SN.

Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12440-4. doi: 10.1002/anie.201606123. Epub 2016 Aug 24.

PMID:
27554600
6.

Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates.

Shaw-Saliba K, Clarke D, Santos JM, Menezes MJ, Lim C, Mascarenhas A, Chery L, Gomes E, March S, Bhatia SN, Rathod PK, Ferreira MU, Catteruccia F, Duraisingh MT.

Int J Parasitol. 2016 Oct;46(11):679-83. doi: 10.1016/j.ijpara.2016.06.003. Epub 2016 Jul 25.

PMID:
27456552
7.

Synchronized cycles of bacterial lysis for in vivo delivery.

Din MO, Danino T, Prindle A, Skalak M, Selimkhanov J, Allen K, Julio E, Atolia E, Tsimring LS, Bhatia SN, Hasty J.

Nature. 2016 Aug 4;536(7614):81-5. Epub 2016 Jul 20.

8.

Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries.

Kwon EJ, Skalak M, Lo Bu R, Bhatia SN.

ACS Nano. 2016 Aug 23;10(8):7926-33. doi: 10.1021/acsnano.6b03858. Epub 2016 Jul 21.

PMID:
27429164
9.

Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain.

Kang J, Joo J, Kwon EJ, Skalak M, Hussain S, She ZG, Ruoslahti E, Bhatia SN, Sailor MJ.

Adv Mater. 2016 Sep;28(36):7962-7969. doi: 10.1002/adma.201600634. Epub 2016 Jul 6.

PMID:
27383373
10.

Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies.

Ramanan V, Trehan K, Ong ML, Luna JM, Hoffmann HH, Espiritu C, Sheahan TP, Chandrasekar H, Schwartz RE, Christine KS, Rice CM, van Oudenaarden A, Bhatia SN.

Virology. 2016 Jul;494:236-47. doi: 10.1016/j.virol.2016.04.020. Epub 2016 Apr 27.

PMID:
27128351
11.

Extracellular matrix microarrays to study inductive signaling for endoderm specification.

Braga Malta DF, Reticker-Flynn NE, da Silva CL, Cabral JM, Fleming HE, Zaret KS, Bhatia SN, Underhill GH.

Acta Biomater. 2016 Apr 1;34:30-40. doi: 10.1016/j.actbio.2016.02.014. Epub 2016 Feb 12.

PMID:
26883775
12.

Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification.

Logan DJ, Shan J, Bhatia SN, Carpenter AE.

Methods. 2016 Mar 1;96:6-11. doi: 10.1016/j.ymeth.2015.12.002. Epub 2015 Dec 11.

13.

Smart nanosystems: Bio-inspired technologies that interact with the host environment.

Kwon EJ, Lo JH, Bhatia SN.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14460-6. doi: 10.1073/pnas.1508522112. Epub 2015 Nov 23. Review.

14.

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.

March S, Ramanan V, Trehan K, Ng S, Galstian A, Gural N, Scull MA, Shlomai A, Mota MM, Fleming HE, Khetani SR, Rice CM, Bhatia SN.

Nat Protoc. 2015 Dec;10(12):2027-53. doi: 10.1038/nprot.2015.128. Epub 2015 Nov 19.

PMID:
26584444
15.

Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity.

Dudani JS, Jain PK, Kwong GA, Stevens KR, Bhatia SN.

ACS Nano. 2015 Dec 22;9(12):11708-17. doi: 10.1021/acsnano.5b05946. Epub 2015 Nov 13.

PMID:
26565752
16.

Mathematical framework for activity-based cancer biomarkers.

Kwong GA, Dudani JS, Carrodeguas E, Mazumdar EV, Zekavat SM, Bhatia SN.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12627-32. doi: 10.1073/pnas.1506925112. Epub 2015 Sep 28.

17.

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.

Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S, Tomchick DR, Deng X, Laird T, Bhatia SN, March S, Ng CL, Fidock DA, Wittlin S, Lafuente-Monasterio M, Benito FJ, Alonso LM, Martinez MS, Jimenez-Diaz MB, Bazaga SF, Angulo-Barturen I, Haselden JN, Louttit J, Cui Y, Sridhar A, Zeeman AM, Kocken C, Sauerwein R, Dechering K, Avery VM, Duffy S, Delves M, Sinden R, Ruecker A, Wickham KS, Rochford R, Gahagen J, Iyer L, Riccio E, Mirsalis J, Bathhurst I, Rueckle T, Ding X, Campo B, Leroy D, Rogers MJ, Rathod PK, Burrows JN, Charman SA.

Sci Transl Med. 2015 Jul 15;7(296):296ra111. doi: 10.1126/scitranslmed.aaa6645.

18.

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors.

Bagley AF, Scherz-Shouval R, Galie PA, Zhang AQ, Wyckoff J, Whitesell L, Chen CS, Lindquist S, Bhatia SN.

Cancer Res. 2015 Aug 15;75(16):3255-67. doi: 10.1158/0008-5472.CAN-15-0325. Epub 2015 Jun 29.

19.

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus.

Ramanan V, Shlomai A, Cox DB, Schwartz RE, Michailidis E, Bhatta A, Scott DA, Zhang F, Rice CM, Bhatia SN.

Sci Rep. 2015 Jun 2;5:10833. doi: 10.1038/srep10833.

20.

Programmable probiotics for detection of cancer in urine.

Danino T, Prindle A, Kwong GA, Skalak M, Li H, Allen K, Hasty J, Bhatia SN.

Sci Transl Med. 2015 May 27;7(289):289ra84. doi: 10.1126/scitranslmed.aaa3519.

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