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Items: 8


Pulsatile exposure to simulated reflux leads to changes in gene expression in a 3D model of oesophageal mucosa.

Green NH, Nicholls Z, Heath PR, Cooper-Knock J, Corfe BM, MacNeil S, Bury JP.

Int J Exp Pathol. 2014 Jun;95(3):216-28. doi: 10.1111/iep.12083. Epub 2014 Apr 8.


Cancer-related inflammation and Barrett's carcinogenesis: interleukin-6 and STAT3 mediate apoptotic resistance in transformed Barrett's cells.

Zhang HY, Zhang Q, Zhang X, Yu C, Huo X, Cheng E, Wang DH, Spechler SJ, Souza RF.

Am J Physiol Gastrointest Liver Physiol. 2011 Mar;300(3):G454-60. doi: 10.1152/ajpgi.00458.2010. Epub 2010 Dec 9.


In vitro and ex vivo models of extended reflux exposure demonstrate that weakly acidic mixed reflux heightens NF-kB-mediated gene expression.

Cronin J, Alhamdani A, Griffiths AP, Baxter JN, Brown T, Jenkins GJ.

Dis Esophagus. 2011 Jul;24(5):360-70. doi: 10.1111/j.1442-2050.2010.01148.x. Epub 2010 Dec 10.


An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-kappaB activation and cytokine levels.

Duggan SP, Behan FM, Kirca M, Smith S, Reynolds JV, Long A, Kelleher D.

Carcinogenesis. 2010 May;31(5):936-45. doi: 10.1093/carcin/bgq036. Epub 2010 Feb 5.


Inhibition of nucleostemin upregulates CDX2 expression in HT29 cells in response to bile acid exposure: implications in the pathogenesis of Barrett's esophagus.

Sun YG, Wang XW, Yang SM, Zhou G, Wang WQ, Wang HB, Wang RQ, Fang DC.

J Gastrointest Surg. 2009 Aug;13(8):1430-9. doi: 10.1007/s11605-009-0899-2. Epub 2009 May 16.


The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF-kappaB activation in oesophageal cells, with a mechanism of action involving ROS.

Jenkins GJ, Cronin J, Alhamdani A, Rawat N, D'Souza F, Thomas T, Eltahir Z, Griffiths AP, Baxter JN.

Mutagenesis. 2008 Sep;23(5):399-405. doi: 10.1093/mutage/gen029. Epub 2008 May 30.


Bile acid-stimulated expression of the farnesoid X receptor enhances the immune response in Barrett esophagus.

Capello A, Moons LM, Van de Winkel A, Siersema PD, van Dekken H, Kuipers EJ, Kusters JG.

Am J Gastroenterol. 2008 Jun;103(6):1510-6. doi: 10.1111/j.1572-0241.2008.01908.x. Epub 2008 May 28.


NF-kappaB activation in esophageal adenocarcinoma: relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy.

Abdel-Latif MM, O'Riordan J, Windle HJ, Carton E, Ravi N, Kelleher D, Reynolds JV.

Ann Surg. 2004 Apr;239(4):491-500.

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