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Sci Rep. 2015 Oct 16;5:15271. doi: 10.1038/srep15271.

Artificial oxygen carriers rescue placental hypoxia and improve fetal development in the rat pre-eclampsia model.

Author information

1
Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodira, Tokyo, Japan.
2
Center for Advanced Biomedical Sciences, Waseda University, Shinjuku-ku, Tokyo, Japan.
3
Image Processing Research Team, RIKEN Center for Advanced Photonics, RIKEN, Wako, Saitama, Japan.
4
Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
5
Department of Pediatrics, St. Luke's International Hospital, Chuo-ku, Tokyo, Japan.
6
Department of Pediatrics, Japanese Red Cross Medical Center, Tokyo, Japan.
7
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
8
Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
9
Department of Chemistry, Faculty of Medicine, School of Medicine, Nara Medical University, Kashihara, Japan.
10
Department of Obstetrics and Gynecology, Tohoku University Hospital, Aoba-ku, Sendai, Japan.

Abstract

Pre-eclampsia affects approximately 5% of all pregnant women and remains a major cause of maternal and fetal morbidity and mortality. The hypertension associated with pre-eclampsia develops during pregnancy and remits after delivery, suggesting that the placenta is the most likely origin of this disease. The pathophysiology involves insufficient trophoblast invasion, resulting in incomplete narrow placental spiral artery remodeling. Placental insufficiency, which limits the maternal-fetal exchange of gas and nutrients, leads to fetal intrauterine growth restriction. In this study, in our attempt to develop a new therapy for pre-eclampsia, we directly rescued placental and fetal hypoxia with nano-scale size artificial oxygen carriers (hemoglobin vesicles). The present study is the first to demonstrate that artificial oxygen carriers successfully treat placental hypoxia, decrease maternal plasma levels of anti-angiogenic proteins and ameliorate fetal growth restriction in the pre-eclampsia rat model.

PMID:
26471339
PMCID:
PMC4608007
DOI:
10.1038/srep15271
[Indexed for MEDLINE]
Free PMC Article

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