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Items: 1 to 20 of 47

1.

Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors.

van der Westhuizen ET, Spathis A, Khajehali E, Jörg M, Mistry SN, Capuano B, Tobin AB, Sexton PM, Scammells PJ, Valant C, Christopoulos A.

Mol Pharmacol. 2018 Jul;94(1):770-783. doi: 10.1124/mol.118.111633. Epub 2018 Apr 24.

PMID:
29691279
2.

Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment.

Weïwer M, Xu Q, Gale JP, Lewis M, Campbell AJ, Schroeder FA, Van de Bittner GC, Walk M, Amaya A, Su P, D Ordevic L, Sacher JR, Skepner A, Fei D, Dennehy K, Nguyen S, Faloon PW, Perez J, Cottrell JR, Liu F, Palmer M, Pan JQ, Hooker JM, Zhang YL, Scolnick E, Wagner FF, Holson EB.

ACS Chem Biol. 2018 Apr 20;13(4):1038-1047. doi: 10.1021/acschembio.8b00168. Epub 2018 Mar 14.

PMID:
29485852
3.

Dopamine D2 Receptors Modulate Pyramidal Neurons in Mouse Medial Prefrontal Cortex through a Stimulatory G-Protein Pathway.

Robinson SE, Sohal VS.

J Neurosci. 2017 Oct 18;37(42):10063-10073. doi: 10.1523/JNEUROSCI.1893-17.2017. Epub 2017 Sep 14.

4.

Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia.

Scarduzio M, Zimmerman CN, Jaunarajs KL, Wang Q, Standaert DG, McMahon LL.

Exp Neurol. 2017 Sep;295:162-175. doi: 10.1016/j.expneurol.2017.06.005. Epub 2017 Jun 3.

PMID:
28587876
5.

The EGF receptor inhibits the signaling of dopamine D3 receptor through the phosphorylation of GRK2 on tyrosine residues.

Sun N, Zhang X, Zhang X, Kim KM.

Biochem Biophys Res Commun. 2017 Aug 5;489(4):515-522. doi: 10.1016/j.bbrc.2017.05.183. Epub 2017 Jun 1.

PMID:
28579429
6.

Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure.

Möller D, Banerjee A, Uzuneser TC, Skultety M, Huth T, Plouffe B, Hübner H, Alzheimer C, Friedland K, Müller CP, Bouvier M, Gmeiner P.

J Med Chem. 2017 Apr 13;60(7):2908-2929. doi: 10.1021/acs.jmedchem.6b01857. Epub 2017 Mar 22.

PMID:
28248104
7.

GSK-3β Interacts with Dopamine D1 Receptor to Regulate Receptor Function: Implication for Prefrontal Cortical D1 Receptor Dysfunction in Schizophrenia.

Wang JR, Sun PH, Ren ZX, Meltzer HY, Zhen XC.

CNS Neurosci Ther. 2017 Feb;23(2):174-187. doi: 10.1111/cns.12664. Epub 2016 Dec 20.

PMID:
27996211
8.

Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.

Urs NM, Gee SM, Pack TF, McCorvy JD, Evron T, Snyder JC, Yang X, Rodriguiz RM, Borrelli E, Wetsel WC, Jin J, Roth BL, O'Donnell P, Caron MG.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8178-E8186. Epub 2016 Dec 1.

9.

New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy.

Urs NM, Peterson SM, Caron MG.

Biol Psychiatry. 2017 Jan 1;81(1):78-85. doi: 10.1016/j.biopsych.2016.10.011. Epub 2016 Oct 19. Review.

10.

RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells.

Luessen DJ, Hinshaw TP, Sun H, Howlett AC, Marrs G, McCool BA, Chen R.

Neuropharmacology. 2016 Nov;110(Pt A):297-307. doi: 10.1016/j.neuropharm.2016.08.009. Epub 2016 Aug 12.

11.

Disruption of Akt signaling decreases dopamine sensitivity in modulation of inhibitory synaptic transmission in rat prefrontal cortex.

Li YC, Yang SS, Gao WJ.

Neuropharmacology. 2016 Sep;108:403-14. doi: 10.1016/j.neuropharm.2016.05.002. Epub 2016 May 6.

12.

Selective disruption of dopamine D2-receptors/beta-arrestin2 signaling by mood stabilizers.

Del' Guidice T, Beaulieu JM.

J Recept Signal Transduct Res. 2015 Jun;35(3):224-32. doi: 10.3109/10799893.2015.1072976. Epub 2015 Oct 12.

PMID:
26459714
13.

Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers.

Harmeier A, Obermueller S, Meyer CA, Revel FG, Buchy D, Chaboz S, Dernick G, Wettstein JG, Iglesias A, Rolink A, Bettler B, Hoener MC.

Eur Neuropsychopharmacol. 2015 Nov;25(11):2049-61. doi: 10.1016/j.euroneuro.2015.08.011. Epub 2015 Aug 20.

PMID:
26372541
14.

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.

McGirr A, Lipina TV, Mun HS, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JG, Liu F, Baillie GS, Clapcote SJ, Roder JC.

Neuropsychopharmacology. 2016 Mar;41(4):1080-92. doi: 10.1038/npp.2015.240. Epub 2015 Aug 14.

15.

Genetic association between G protein-coupled receptor kinase 6/β-arrestin 2 and dopamine supersensitivity psychosis in schizophrenia.

Oda Y, Kanahara N, Kimura H, Watanabe H, Hashimoto K, Iyo M.

Neuropsychiatr Dis Treat. 2015 Jul 29;11:1845-51. doi: 10.2147/NDT.S86042. eCollection 2015.

16.

Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice.

Park SM, Chen M, Schmerberg CM, Dulman RS, Rodriguiz RM, Caron MG, Jin J, Wetsel WC.

Neuropsychopharmacology. 2016 Feb;41(3):704-15. doi: 10.1038/npp.2015.196. Epub 2015 Jul 1.

17.

Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor.

Peterson SM, Pack TF, Wilkins AD, Urs NM, Urban DJ, Bass CE, Lichtarge O, Caron MG.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7097-102. doi: 10.1073/pnas.1502742112. Epub 2015 May 11.

18.

Structure and function of serotonin G protein-coupled receptors.

McCorvy JD, Roth BL.

Pharmacol Ther. 2015 Jun;150:129-42. doi: 10.1016/j.pharmthera.2015.01.009. Epub 2015 Jan 17. Review.

19.

Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways.

Brust TF, Hayes MP, Roman DL, Burris KD, Watts VJ.

J Pharmacol Exp Ther. 2015 Mar;352(3):480-93. doi: 10.1124/jpet.114.220293. Epub 2014 Dec 24.

20.

(-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling.

Meade JA, Free RB, Miller NR, Chun LS, Doyle TB, Moritz AE, Conroy JL, Watts VJ, Sibley DR.

Psychopharmacology (Berl). 2015 Mar;232(5):917-30. doi: 10.1007/s00213-014-3726-8. Epub 2014 Sep 18.

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