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Appican, the proteoglycan form of the amyloid precursor protein, contains chondroitin sulfate E in the repeating disaccharide region and 4-O-sulfated galactose in the linkage region.

Tsuchida K, Shioi J, Yamada S, Boghosian G, Wu A, Cai H, Sugahara K, Robakis NK.

J Biol Chem. 2001 Oct 5;276(40):37155-60. Epub 2001 Jul 30.


Appican expression induces morphological changes in C6 glioma cells and promotes adhesion of neural cells to the extracellular matrix.

Wu A, Pangalos MN, Efthimiopoulos S, Shioi J, Robakis NK.

J Neurosci. 1997 Jul 1;17(13):4987-93.


Characterization of appican, the chondroitin sulfate proteoglycan form of the Alzheimer amyloid precursor protein.

Pangalos MN, Shioi J, Efthimiopoulos S, Wu A, Robakis NK.

Neurodegeneration. 1996 Dec;5(4):445-51. Review.


The Alzheimer amyloid precursor proteoglycan (appican) is present in brain and is produced by astrocytes but not by neurons in primary neural cultures.

Shioi J, Pangalos MN, Ripellino JA, Vassilacopoulou D, Mytilineou C, Margolis RU, Robakis NK.

J Biol Chem. 1995 May 19;270(20):11839-44.


The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene.

Pangalos MN, Efthimiopoulos S, Shioi J, Robakis NK.

J Biol Chem. 1995 May 5;270(18):10388-91.

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