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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1958 1
1959 6
1960 8
1961 8
1962 10
1963 11
1964 94
1965 64
1966 12
1967 15
1968 13
1969 11
1970 12
1971 11
1972 16
1973 14
1974 20
1975 23
1976 17
1977 24
1978 26
1979 40
1980 89
1981 215
1982 388
1983 363
1984 386
1985 325
1986 320
1987 319
1988 375
1989 433
1990 395
1991 435
1992 490
1993 509
1994 515
1995 513
1996 554
1997 574
1998 547
1999 532
2000 595
2001 633
2002 710
2003 739
2004 776
2005 794
2006 902
2007 958
2008 1025
2009 1078
2010 1066
2011 1005
2012 1026
2013 1032
2014 1024
2015 1021
2016 944
2017 933
2018 927
2019 894
2020 809
2021 762
2022 637
2023 596
2024 191

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27,328 results

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Page 1
Inadequate Response to Treatment in Major Depressive Disorder: Augmentation and Adjunctive Strategies.
Rafeyan R, Papakostas GI, Jackson WC, Trivedi MH. Rafeyan R, et al. J Clin Psychiatry. 2020 May 12;81(3):OT19037BR3. doi: 10.4088/JCP.OT19037BR3. J Clin Psychiatry. 2020. PMID: 32412697 Free article. Review.
About 30%-50% of patients experience inadequate response to antidepressant therapy, and treatment choices for these patients include augmenting the antidepressant with another therapy, increasing the dose, switching to a different antidepressant, or combining antide …
About 30%-50% of patients experience inadequate response to antidepressant therapy, and treatment choices for these patients include …
Treatment-Resistant Depression: Approaches to Treatment.
Kverno KS, Mangano E. Kverno KS, et al. J Psychosoc Nurs Ment Health Serv. 2021 Sep;59(9):7-11. doi: 10.3928/02793695-20210816-01. Epub 2021 Sep 1. J Psychosoc Nurs Ment Health Serv. 2021. PMID: 34459676 Review.
Approximately 30% of people treated for a major depressive episode will not achieve remission after two or more treatment trials of first-line antidepressants and are considered to have treatment-resistant depression (TRD). Because the odds of remission decrease with every …
Approximately 30% of people treated for a major depressive episode will not achieve remission after two or more treatment trials of f …
The mistreatment of major depressive disorder.
Paris J. Paris J. Can J Psychiatry. 2014 Mar;59(3):148-51. doi: 10.1177/070674371405900306. Can J Psychiatry. 2014. PMID: 24881163 Free PMC article. Review.
OBJECTIVE: To examine the effects of classification on treatment in major depressive disorder (MDD). METHOD: This is a narrative review. RESULTS: MDD is a highly heterogeneous category, leading to problems in classification and in specificity of treatment. ...Howeve …
OBJECTIVE: To examine the effects of classification on treatment in major depressive disorder (MDD). METHOD: This is a narrati …
Management of Depression in Older Adults: A Review.
Kok RM, Reynolds CF 3rd. Kok RM, et al. JAMA. 2017 May 23;317(20):2114-2122. doi: 10.1001/jama.2017.5706. JAMA. 2017. PMID: 28535241 Review.
Antidepressants are the best-studied treatment option, but psychotherapy, exercise therapy, and electroconvulsive therapy may also be effective. Psychotherapy is recommended for patients with mild to moderate severity depression. ...CONCLUSIONS AND RELEVANCE: Major …
Antidepressants are the best-studied treatment option, but psychotherapy, exercise therapy, and electroconvulsive therapy may …
The sequenced treatment alternatives to relieve depression (STAR*D) trial: a review.
Sinyor M, Schaffer A, Levitt A. Sinyor M, et al. Can J Psychiatry. 2010 Mar;55(3):126-35. doi: 10.1177/070674371005500303. Can J Psychiatry. 2010. PMID: 20370962 Review.
OBJECTIVE: The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial is the largest open-label, pragmatic trial that has been undertaken to examine the treatment of major depressive disorder. At a cost of US$35 million over 6 years, STAR*D sought to …
OBJECTIVE: The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial is the largest open-label, pragmatic trial that has bee …
Neurobiology of depression and mechanism of action of depression treatments.
Blier P. Blier P. J Clin Psychiatry. 2016 Mar;77(3):e319. doi: 10.4088/JCP.13097tx3c. J Clin Psychiatry. 2016. PMID: 27046319 Free article.
Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), may alleviate depressive symptoms but also leave residual symptoms. The mechanism of action of SSRIs increases serotonin (5-HT) activity but decreases norepinephrine (NE) and dopamine (DA) activity. …
Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), may alleviate depressive symptoms but also leave residual s …
Rational site-directed pharmacotherapy for major depressive disorder.
Blier P. Blier P. Int J Neuropsychopharmacol. 2014 Jul;17(7):997-1008. doi: 10.1017/S1461145713000400. Epub 2013 Jun 10. Int J Neuropsychopharmacol. 2014. PMID: 23745670 Free article. Review.
It is now accepted that major depressive disorder (MDD) is not a single pathophysiological entity. ...
It is now accepted that major depressive disorder (MDD) is not a single pathophysiological entity. ...
Antidepressants.
Salzman C. Salzman C. Clin Geriatr Med. 1990 May;6(2):399-410. Clin Geriatr Med. 1990. PMID: 2184931 Review.
Depressive symptoms are common in the elderly, and depressive illness is the most common of emotional disorders in those of advanced age. ...
Depressive symptoms are common in the elderly, and depressive illness is the most common of emotional disorders in those of ad …
Treatment-resistant depression.
Souery D, Papakostas GI, Trivedi MH. Souery D, et al. J Clin Psychiatry. 2006;67 Suppl 6:16-22. J Clin Psychiatry. 2006. PMID: 16848672 Review.
Treatment-resistant depression (TRD) is a common clinical occurrence among patients treated for major depressive disorder. However, a clear consensus regarding the criteria defining TRD is lacking in the psychiatric community. ...While several studies have identifie …
Treatment-resistant depression (TRD) is a common clinical occurrence among patients treated for major depressive disorder. How …
Cognitive effects of pharmacotherapy for major depressive disorder: a systematic review.
Keefe RS, McClintock SM, Roth RM, Doraiswamy PM, Tiger S, Madhoo M. Keefe RS, et al. J Clin Psychiatry. 2014 Aug;75(8):864-76. doi: 10.4088/JCP.13r08609. J Clin Psychiatry. 2014. PMID: 25099527 Free article. Review.
OBJECTIVE: Cognitive impairment frequently accompanies major depressive disorder (MDD) and can persist during remission. This review examined pharmacotherapy effects on cognitive function in MDD. ...Sample weighted mean effect sizes revealed that verbal memor …
OBJECTIVE: Cognitive impairment frequently accompanies major depressive disorder (MDD) and can persist during remission. This …
27,328 results
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